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Preparation processes of porous hydrogel and nonporous hydrogel

A technology of porous hydrogel and preparation process, which is applied in the field of preparation technology of porous hydrogel and non-porous hydrogel, can solve the problems such as difficulties and difficulties in drug loading of hydrogel, and achieves reduction of production cost, simplification of production process, The effect of improving production efficiency

Inactive Publication Date: 2013-04-17
古元安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At the same time, the traditional hydrogel drug loading is relatively difficult, and the hydrogel must be washed and dried after the cross-linking polymerization reaction is completed, and then the drug can be adsorbed to form a drug-containing hydrogel.
In this way, if a continuous production process is required, it will be difficult

Method used

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  • Preparation processes of porous hydrogel and nonporous hydrogel
  • Preparation processes of porous hydrogel and nonporous hydrogel

Examples

Experimental program
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Embodiment 1

[0040] figure 1 It is a schematic flow chart of the preparation process of the porous hydrogel in Example 1 of the present invention.

[0041] refer to figure 1 As shown, the embodiment of the present invention provides a porous hydrogel preparation process, comprising the following steps:

[0042] S1: preparing a mixed raw material, which includes a reactive monomer, a photoinitiator, a crosslinking agent, a moisturizing agent and water;

[0043] S2: performing rapid cooling on the mixed raw materials in the above steps, while introducing air and stirring at a high speed to obtain a porous colloid;

[0044] S3: Continuously coating the above-mentioned porous bubble colloid on the substrate to form a colloid coating, and at the same time, irradiating with ultraviolet light to cause a cross-linking reaction of the colloid coating to form a hydrogel layer;

[0045] S4: Paste a non-stick mucous membrane on the hydrogel layer to form a hydrogel sheet-like coil with porous bubbl...

Embodiment 2

[0058] Fig. 2 is a schematic flow chart of the preparation process of the non-porous hydrogel in Example 2 of the present invention.

[0059] Referring to Fig. 2, the embodiment of the present invention also provides a non-porous hydrogel preparation process, which differs from the porous hydrogel preparation process shown in Example 1 mainly in that during the rapid cooling process, no air, and the entire cooling process is completed in a vacuum container, the specific steps are as follows:

[0060] P1: Prepare mixed raw materials, which include reactive monomers, photoinitiators, crosslinking agents, moisturizing agents and water;

[0061] P2: Put the mixed raw materials in the above steps into a vacuum container, perform a rapid cooling treatment on the vacuum container, and stir at a high speed at the same time to obtain a non-porous colloid;

[0062] P3: Continuously coating the non-porous colloid in step P2 on the substrate to form a colloid coating, and at the same tim...

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Abstract

The invention relates to a porous hydrogel preparation process which comprises the following steps: preparing mixed raw materials, quickly cooling the mixed raw materials, simultaneously introducing air, and stirring at a high speed to obtain porous bubble colloid; then, continuously coating the porous bubble colloid onto a substrate, and simultaneously performing ultraviolet irradiation to form a hydrogel layer; and finally, bonding a non-adhesive film on the hydrogel layer to form a porous bubble hydrogel sheet-like coiled material. The invention also provides a nonporous hydrogel preparation process. According to the invention, porous bubble hydrogel and nonporous hydrogel dressings can be manufactured in a continuous production mode, and the manufacturing process of the hydrogel dressings can be simplified, thereby greatly improving the preparation efficiency of the hydrogel dressings and achieving the purpose of lowering the hydrogel production cost.

Description

technical field [0001] The invention relates to the technical field of preparation of hydrogel medical dressings, in particular to a preparation process of porous hydrogel and non-porous hydrogel. Background technique [0002] The control of wound exudate, known as moisture control, has become a major focus of current wound dressing designs. All dressings used in medicine can control wound exudate through absorption, wetting and water penetration. The purpose of a moist wound dressing is to maintain a proper balance of moisture in the wound environment, which is necessary for the natural wound healing process. [0003] Currently, wound dressings for maintaining a moist wound environment range from gels to films, foams, alginates, and hydrocolloids (see Szycher et al., J. Biomater, Appl. 7:142-213, 1992). [0004] Thin film wound dressings consist of a synthetic polymeric film coated on one side with a pressure sensitive adhesive. Wound exudate accumulation and concentrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/30C08J5/18C08J3/28C08J3/24C08F290/06A61L15/24
Inventor 古元安
Owner 古元安
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