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Rapid response hydrogel film glucose optical sensor

An optical sensor and fast-response technology, applied in the field of glucose optical sensors, can solve the problems that need to be further improved, the hemispherical hydrogel is not, and achieve the effects of increased swelling speed, fast response, and improved response speed

Inactive Publication Date: 2012-02-15
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Faster sensor response due to the use of smaller hydrogels, but still needs to be further improved
In addition, Fabry-Perot interference requires that the two interfaces that make up the Fabry-Perot interference cavity be parallel, and the hemispherical hydrogel is obviously not an ideal Fabry-Perot interference cavity

Method used

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  • Rapid response hydrogel film glucose optical sensor
  • Rapid response hydrogel film glucose optical sensor
  • Rapid response hydrogel film glucose optical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 0.500 g of acrylamide, 0.150 g of 3-acrylamidophenylboronic acid and 4.0 mg of azobisisobutyronitrile were dissolved in 40 mL of dimethylformamide. Deoxygenate with nitrogen gas for 30 minutes. Heated to 70°C under nitrogen protection, and reacted for 12 hours. The product was precipitated in acetone, filtered, washed with acetone several times, and dried in vacuum to obtain acrylamide-3-acrylamidophenylboronic acid copolymer.

[0028] Clean substrates (quartz, glass or polished silicon wafers) were soaked in 0.1wt% polyvinyl alcohol solution for 10 minutes, washed with water for 4 minutes, and then soaked in 0.1wt% acrylamide-3-acrylamidophenylboronic acid copolymer solution for 10 minutes. minutes, and then washed for 4 minutes. Repeat this alternate assembly process to obtain the layer-by-layer self-assembled film of polyvinyl alcohol / acrylamide-3-acrylamide phenylboronic acid copolymer.

Embodiment 2

[0030] Measure the reflectance spectrum of the self-assembled film that obtains in embodiment 1 with fiber optic spectrometer, as image 3 shown. The reflection spectrum of the self-assembled film presents a series of peaks and troughs, namely Fabry-Perot fringes. The cause of the streaks is as described above. When the self-assembled film was placed in deionized water, clear Fabry-Perot fringes could still be observed, but the amplitude of the fringes decreased, and the fringe density increased due to the swelling of the film in water. ( image 3 ) These results prove that the self-assembled membrane obtained in Example 1 can swell in water and has the properties of a hydrogel film.

Embodiment 3

[0032] The self-assembled hydrogel membrane obtained in Example 1 was soaked in 0.050M pH8.5 phosphate buffer solution containing different concentrations of glucose at 25°C. The reflectance spectrum of the thin film is measured with a fiber optic spectrometer, such as Figure 4 shown. It can be seen that the reflectance spectrum of the self-assembled hydrogel film presents clear Fabry-Perot interference fringes, and the interference fringes move with the glucose concentration.

[0033] Depend on Figure 4 The positions of the Fabry-Perot interference fringes in , calculate the optical path length of the self-assembled hydrogel film in different glucose concentrations, such as Figure 5 shown. It can be seen that the optical path length of the self-assembled hydrogel film increases linearly with the increase of glucose concentration. That is, the concentration of glucose in the solution can be determined by the determination of the Fabry-Perot interference fringes.

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PUM

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Abstract

The invention discloses a rapid response optical glucose sensor based on glucose sensitive hydrogel film. The hydrogel film used for sensing has two properties that on one hand, a swellbility of the hydrogel film in aqueous solution is changed with a glucose concentration in the solution; on the other hand, an absorption spectrum or a reflection spectrum has Fabry-Perot interference fringes. The change of glucose concentration leads to change of hydrogel film swellbility, so as to cause moving of the Fabry-Perot interference fringes; therefore the moving of the Fabry-Perot interference fringes indicates the change of glucose concentration in the solution. The invention utilizes a layer by layer assembly method to prepare the glucose sensitive hydrogel film with a thickness from hundreds nanometers to micrometers, so as to conduct rapid response.

Description

technical field [0001] The invention relates to a glucose optical sensor based on an intelligent hydrogel film, more specifically, relates to a hydrogel film sensor utilizing the Fabry-Perot diffraction fringes of the film to move as the glucose concentration changes. The sensor can be applied to technical fields such as chemistry, food and biomedicine. Background technique [0002] The swelling degree of glucose-sensitive hydrogel in water changes with the change of glucose concentration, and it can be used as a sensitive element and an appropriate conversion element to form a glucose sensor. In particular, label-free optical sensors can be obtained if combined with optical interference phenomena. The optical sensor based on glucose-sensitive hydrogel has the advantages of simplicity and low cost, and is expected to be applied in technical fields such as chemistry, food, and biomedicine, especially the blood glucose detection of diabetics. [0003] Articles by S.A.Asher e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/45
Inventor 张拥军张曦关英
Owner NANKAI UNIV
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