Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites

A composite material and fiber-reinforced technology, which is applied in the field of fiber-reinforced hydrogel composite materials to form fiber-reinforced hydrogel composite materials, can solve problems such as blocking

Inactive Publication Date: 2015-04-01
TECHNION RES & DEV FOUND LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the incorporation of fibers and their suitable dispersion within the host material still presents technical challenges, especially in the case of injectable hydrogels where injectability is required and clogging of needles must be avoided

Method used

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  • Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites
  • Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites
  • Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites

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other Embodiment approach

[0079] Other implementations are within the scope of the claims and non-limiting examples. In addition, where features or aspects of the invention are described in terms of Markush groups, those skilled in the art will recognize that the invention is also thereby described in terms of any individual member or subgroup of members of the Markush group.

[0080] Example part

[0081] The exemplary embodiment shown below relates to a hybrid material comprising a hydrogel of dextran dialdehyde-cross-linked gelatin embedded with electrospun bovine serum albumin fibers. In this embodiment, the length of each fiber used ranges from about 100 μm to about 1000 μm. Incorporating fibers at a weight fraction of about 1% to about 6% increases the hydrogel elastic modulus by about 40% and reduces the gel time by about 20%.

[0082] Hybrid scaffolds, including hydrogels and short electrospun fibers, are also provided. Dextran dialdehyde-crosslinked gelatin was used as the hydrogel componen...

Embodiment 1

[0083] Example 1: Materials

[0084] Gelatin (type A, from pig skin), dextran (70 kDa, from Leuconostoc spp.), sodium periodate (ACS reagent, >99.8% pure), sodium tetraborate decahydrate (Borax) and 2,2,2-trifluoroethanol (TFE, Reagent Plus (R)) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Bovine serum albumin (BSA, Fraction V) was purchased from MP Biomedicals (Solon, OH, USA). 2-Mercaptoethanol (ME, molecular biology grade) was purchased from Merck (Darmstadt, Germany). All compounds were used without further modification.

Embodiment 2

[0085] Embodiment 2: Preparation of composite material hydrogel

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Abstract

A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 mu m. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method using the fiber-reinforced composite are also provided.

Description

[0001] Cross reference to related applications [0002] This application claims the benefit of priority to US Provisional Application No. 61 / 647,166, filed May 15, 2012, the contents of which are hereby incorporated by reference in their entirety for all purposes. technical field [0003] The present invention relates to hydrogels, and more particularly, to fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites. Background technique [0004] Hydrogels are mainly composed of synthetic or natural hydrophilic polymers. Due to their 3D structure resembling extracellular matrix (ECM), hydrogels have been used as tissue substitutes, space-filling scaffolds, and cell carriers. For maximum benefit, hydrogel compositions must meet the mechanical (eg modulus), physical (eg mass transfer) and biological (eg cell-matrix interaction) requirements of each biomedical application under consideration. In particular, injectable hydrogels are attract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52
CPCA61L27/52A61L27/48A61L2400/06Y10T428/31978C08L89/06A61F2/02A61L27/26A61L2430/00
Inventor 埃亚尔·祖斯曼斯里尼瓦萨·雷迪·恰加蒂贾亚拉马·雷迪·韦努戈帕攀希拉姆·罗摩衍那奥马里·勒热夫
Owner TECHNION RES & DEV FOUND LTD
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