Double-sustained-release drug-loaded hydrogel dressing with semi-interpenetrating network entrapped double-layer microspheres as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of medical dressings for repairing burn skin wounds, and provides a double-sustained-release drug-loaded hydrogel dressing with double-layer microspheres entrapped by a semi-interpenetrating network. Acrylic acid is used as a pH-sensitive monomer. The pH / temperature dual-sensitive intelligent hydrogel takes methacrylic acid 2-ethyl ester and oligomeric (ethylene glycol) methyl ether methacrylate as temperature-sensitive monomers, and an anti-inflammatory drug gentamicin sulfate is entrapped; the preparation method comprises the following steps: preparing a calcium alginate core sphere entrapped with bovine serum albumin through a high-voltage electrostatic instillation method, coating the surface of the core sphere with a chitosan shell layer entrapped with an antibacterial drug azithromycin to form a double-layer microsphere, and loading the double-layer microsphere into the hydrogel to obtain the hydrogel dressing capable of precisely and slowly releasing two drugs and one protein. According to the pH / temperature change of a wound surface microenvironment, the hydrogel can achieve accurate controlled release of drugs and improve the utilization rate of the drugs, and is a novel double-sustained-release drug-loaded hydrogel dressing with a semi-interpenetrating network combined double-layer microsphere structure and good comprehensive performance.

Description

technical field

[0001] The invention belongs to the technical field of medical dressings for repairing burned skin wounds, and in particular relates to a double-sustained-release drug-loaded hydrogel dressing containing double-layer microspheres in a semi-interpenetrating network and a preparation method and application thereof. Background technique

[0002] Skin damage caused by burns can easily lead to bacterial infection, which can threaten the life and health of patients in severe cases. As a covering for wounds, medical dressings can replace damaged skin as a temporary barrier during the wound healing process, providing an environment conducive to wound healing. At present, most medical dressings are foam dressings. If there is a large amount of exudate in the wound, the foam that absorbs a large amount of exudate will seep back to the wound surface, and the wound surface will be prone to whitishness and ulceration after being soaked in the exudate for a long time. Nor...

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