Glycine betaine ester intelligent hydrogel relatively controllable in structure and preparation method and application

A technology of betaine ester and betaine, which is applied in the field of betaine ester intelligent hydrogel and its preparation, can solve the problems of harsh reaction conditions, high prices of catalysts and complexing agents, and the need to expand the grafted surface, etc., to achieve low Effect of protein adsorption properties

Inactive Publication Date: 2013-04-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: ATRP reaction conditions are harsh and must be operated in an oxygen-free environment; the catalysts and complexing agents that must be used in the ATRP reaction process are expensive, and the remo

Method used

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  • Glycine betaine ester intelligent hydrogel relatively controllable in structure and preparation method and application
  • Glycine betaine ester intelligent hydrogel relatively controllable in structure and preparation method and application
  • Glycine betaine ester intelligent hydrogel relatively controllable in structure and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) The preparation of RAFT reagent benzyl dithiobenzoate, the specific operation includes the following process:

[0043] Add 250ml of anhydrous THF, 62.8g of bromobenzene and 10g of magnesium chips into a three-necked flask, and react at room temperature to prepare phenylmagnesium bromide. Then the solution was heated to 40° C. and 30.44 g of carbon disulfide was added within 15 minutes while maintaining the reaction temperature at 40° C. for 2 hours to obtain a dark brown solution. 76.95ml of benzyl bromide was added dropwise, and the reaction was maintained at 50°C for 2h. After completion of the reaction, add 1500ml of ice water to the reaction mixture, and extract it several times with diethyl ether. The ether layer is washed with water and aqueous sodium bicarbonate solution successively, dried over anhydrous magnesium sulfate, filtered, and the red oily viscous liquid distilled under reduced pressure is RAFT reagent benzyl dithiobenzoate.

[0044] 2) One-step p...

Embodiment 2

[0047] 1) The preparation of RAFT reagent benzyl dithiobenzoate, the specific operation scheme is the same as that in Example 1.

[0048] 2) One-step preparation of betaine ester smart hydrogel

[0049] Add 0.55g betaine carboxylate, 0.65g N-isopropylacrylamide, 0.05g N,N'-methylene bisacrylamide, 0.01g benzyl dithiobenzoate, 7ml deionized water into a 50ml beaker , fully dissolved under magnetic stirring. Add 0.0075g of potassium persulfate into the beaker and stir evenly. The uniformly mixed solution was added to a glass tube with a length of 20 cm and a diameter of 20 mm, and the nitrogen gas was pumped and vacuumed for 6 times. Under the protection of nitrogen atmosphere, the reaction was carried out in an oil bath at 55°C for 36 hours to obtain a betaine ester hydrogel. The gel was taken out, soaked in deionized water for 2 weeks, and the water was changed every 12 hours to remove unreacted monomer molecules to obtain a betaine ester smart hydrogel.

Embodiment 3

[0051] 1) The preparation of RAFT reagent benzyl dithiobenzoate, the specific operation scheme is the same as that in Example 1.

[0052] 2) One-step preparation of betaine ester smart hydrogel

[0053] Add 0.2g betaine carboxylate, 1.0g N-isopropylacrylamide, 0.07g N,N'-methylene bisacrylamide, 0.01g benzyl dithiobenzoate, 9ml deionized water, fully dissolved under magnetic stirring. Then weigh 0.01g of potassium persulfate, add it to the beaker, and stir evenly. The uniformly mixed solution was added to a glass tube with a length of 20 cm and a diameter of 20 mm, vacuum pumping and nitrogen gas was repeated 9 times, under the protection of nitrogen atmosphere, the oil bath was reacted at 75 ° C for 24 h to obtain a betaine ester hydrogel. The gel was taken out, soaked in deionized water for 2 weeks, and the water was changed every 12 hours to remove unreacted monomer molecules to obtain a betaine ester smart hydrogel.

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Abstract

The invention discloses a glycine betaine ester intelligent hydrogel relatively controllable in structure and a preparation method and application. The glycine betaine ester intelligent hydrogel relatively controllable in structure comprises, by weight, 0.2-0.9 part of carboxylic acid glycine betaine esters, 0.3-1 part of N- isopropyl acrylamide, 0.005-0.01part of initiators, 0.03-0.07 part of cross-linking agents, 0.01 part of reversible additive fragment transfer (RAFT) reagents and 5-9 parts of solvents. Solution polymerization or emulsion polymerization is carried out by means of an RAFT free radical polymerization method. An obtained glycine betaine ester intelligent hydrogel which is relatively controllable in structure and molecular weight has the good performance of sterilization, self-cleaning, soil release and the like. The glycine betaine ester intelligent hydrogel can be applied to a controllable drug sustained-release system and artificial cartilages, implantable biological materials of internal biosensors, and the like.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a betaine ester intelligent hydrogel with a relatively controllable structure and a preparation method and application thereof. technical background [0002] Polycarboxybetaine (PCB, Polycarboxybetaine) has a long history in polybetaine compounds. It has recently been confirmed that the adsorption of non-specific proteins (<0.3ng.cm －2 ). This is difficult to achieve with other substances, even PEG (Ployethylene glycol, polyethylene glycol). Another unique feature of PCB is that it can be produced by substituting carboxyl groups with ester groups during the hydrolysis process, while polycarboxylate betaine is positively charged. This cationic polycarboxylate betaine is compatible with proteins, Special properties arise when DNA and bacteria interact. Cheng et al. (Angewandte Chemie-International Edition, 2008, 47(46), 8831-8834. and Langmuir, 2001, 17(9), ...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/22C08F2/38C08F293/00C08J3/075A61K47/32A61L27/16A61L27/52A61L27/54A61L31/04A61L31/16
Inventor 徐守萍曾仁昌皮丕辉蔡智奇文秀芳程江
Owner SOUTH CHINA UNIV OF TECH
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