Lubricating hydrogel material, and preparation method and application thereof

A gel material, lubricating water technology, used in prosthesis, tissue regeneration, medical science, etc., can solve the problem of difficult to achieve balance between high strength and water content of synthetic cartilage, poor biocompatibility, limited self-healing ability, etc. problem, to achieve the effect of high strength, simple operation and wide pH response range

Active Publication Date: 2019-11-26
JILIN UNIV
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Problems solved by technology

[0002] Due to the avascular structure and nerveless tissue of human articular cartilage, the self-healing ability is limited when it is damaged or joint disease occurs. Most patients ne

Method used

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  • Lubricating hydrogel material, and preparation method and application thereof
  • Lubricating hydrogel material, and preparation method and application thereof
  • Lubricating hydrogel material, and preparation method and application thereof

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preparation example Construction

[0033] The invention provides a preparation method of a lubricating hydrogel material, comprising the following steps:

[0034] (1) mixing the first monomer, photoinitiator, crosslinking agent and solvent, and performing the first ultraviolet irradiation treatment to obtain a single network hydrogel;

[0035] (2) mixing the second monomer, supramolecular monomer, photoinitiator, crosslinking agent and solvent to obtain a reaction solution;

[0036] (3) soaking the single-network hydrogel into the reaction solution, and performing a second ultraviolet irradiation treatment to obtain an interpenetrating network hydrogel;

[0037] (4) mixing the interpenetrating network hydrogel material and a pH regulator to swell to obtain a lubricating hydrogel material;

[0038] The step (1) and step (2) have no temporal sequence;

[0039] The first monomer and the second monomer independently include amide monomers, acrylic monomers, [2-(acryloyloxy) ethyl] trimethylammonium chloride, poly...

Embodiment 1

[0072] (1) At room temperature, 20.725g of 2-acrylamide-2-methylpropanesulfonate sodium solid powder and 50mL of deionized water were added to a 100mL Erlenmeyer flask, and magnetically stirred at a speed of 600r / min for 3h. Dissolve the solid powder; add 0.07305g ketoglutaric acid solid powder and 0.30834g N,N-dimethylacrylamide solid powder, stir magnetically at a speed of 600r / min for 2h to dissolve the solid; add the resulting mixed solution into the mold, Irradiate for 20 minutes under ultraviolet light with a wavelength of 365nm to obtain a single-network hydrogel;

[0073] (2) At room temperature, add 85.296g of acrylamide solid powder and 300mL of deionized water into a 500mL Erlenmeyer flask, stir magnetically at a speed of 600r / min for 2h to dissolve the solid powder; add 1.532g of ketoglutaric acid Solid powder and 0.1850g N,N-dimethylacrylamide solid powder were magnetically stirred for 2h to dissolve the solid; 1.8g chitosan solid powder was added, 3mL acetic acid...

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Abstract

The invention provides a lubricating hydrogel material, and a preparation method and an application thereof, and belongs to the technical field of intelligent hydrogels. A covalent interpenetrating network hydrogel formed by a first monomer and a second monomer in the prepared lubricating hydrogel material makes the hydrogel have good mechanical properties and simulate the compression resistance and load bearing characteristics of articular cartilage; weak non-covalent bond interaction between supramolecular monomers is prone to gel-sol conversion when the pH value is changed, so possibility is brought for the appearance of a liquid layer on the surface of the hydrogel; and after the lubricating hydrogel is treated by a pH regulator, the non-covalent supramolecular part is subjected to assembling-disassembling reversible conversion, and the disassembled supramolecular part becomes a sol, and plays a role in lubricating on the surface of the hydrogel. The lubricating mechanism of the lubricating hydrogel material provided by the invention is same to the exudation lubricating mechanism of human articular cartilage, and the prepared lubricating hydrogel material has the advantages ofhigh strength, wide pH response range, simplicity in operation, and suitableness for industrial production.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to an intelligent lubricating hydrogel material and its preparation method and application. Background technique [0002] Due to the avascular structure and nerveless tissue of human articular cartilage, the self-healing ability is limited when it is damaged or joint disease occurs. Most patients need artificial cartilage transplantation. However, it is difficult to achieve a balance between high strength and water content in traditional synthetic cartilage. Biocompatibility is poor. [0003] Because the hydrogel has a good three-dimensional network structure, the water content is similar to that of the human body, and its loose and porous structure is suitable for cell proliferation, adhesion, and free entry and exit of joint synovial fluid; and the mechanical strength of high-strength hydrogel is comparable to that of human articular cartilage. The mechanical strength is close,...

Claims

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Application Information

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IPC IPC(8): C08F220/58C08F220/54C08F2/48C08F220/56C08F251/00C08F251/02C08F220/36C08F257/00A61L27/20A61L27/16A61L27/52
CPCA61L27/16A61L27/20A61L27/52A61L2430/06C08F2/48C08F220/58C08F251/00C08F251/02C08F257/00C08F220/56
Inventor 宋文龙张爽
Owner JILIN UNIV
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