A method for Mo-99
irradiation production and
energy spectrum optimization based on reactor activation is proposed. This method establishes a three-dimensional high-fidelity neutronics and
burnup coupling model of the reactor and
irradiation channels. The full
neutron energy range is divided into 238 energy regions, and perturbations are applied to the flux of each individual energy region. This yields the importance indicators and curves of Mo-99 production on flux changes in each energy region, thereby identifying positively and negatively important performance regions. For negatively important performance regions, filter nuclides are screened from the absorption cross-section characteristics of natural isotopes, and
burnup calculations are performed at different
doping levels to obtain production gains. The
isotope scheme is then converted into a
natural abundance material scheme to determine the optimal
filter material and loading method. This invention, through integrated
energy spectrum optimization—refined
energy spectrum analysis, filter
nuclide screening, determination of the optimal energy spectrum control scheme, and
impurity assessment—can increase Mo-99 production without adding extra post-
processing steps and reduce the risk of radioactive
impurity introduction. It is applicable to the industrial and regional supply of Mo-99 for various reactor platforms, including commercial and research reactors.