The invention discloses a molten salt depleted uranium reactor, belonging to the technical field of molten salt reactors; fast neutron spectrum, chloride molten salt, uranium plutonium cycle and depleted uranium are used; after start, only by use of a nuclear fuel of self proliferation, long-term stable and safe operation can be achieved, and a supercritical accident may not happen; negative feedback can keep in the critical state; the entire uranium plutonium cycle can be completed in the reactor; normal operation only requires the use of the depleted uranium, the reactor itself does not need uranium enrichment and purification; and high burnup of the depleted uranium can be realized. The reactor has the advantages of simple structure and easy operation, is very suitable for large-scale popularization and application. The reactor is applicable to various types of molten salt formulas and structure materials. The technology, complete set of system technology, engineering and industrialization are feasible. The preferred system is as follows: simplified low temperature IV type + 316 stainless steel main container + nitrogen coolant + 318 stainless steel pipeline pump heat exchanger and the like. Fission nuclear energy can be used to fully meet the national long-term energy needs, at the same time, the problems of the shortage of uranium resources, nuclear criticality safety and low carbon development can be solved, and the reactor is mainly used for heat, electricity or mechanical power supply.