The invention discloses a floating grid-based nuclear-thermal-mechanical multi-physical coupling calculation method. The method comprises the steps of establishing a fuel rod geometric model, carryingout a nuclear-thermal-force multi-physical iterative calculation process, carrying out plane heat transfer calculation, plane mechanics calculation and plane neutron transport calculation, and carrying out axial one-dimensional neutron diffusion calculation. According to the invention, neutronics, thermal hydraulic and mechanical problems are solved based on deformable floating grid coupling, andbehaviors of heat conduction, mechanical deformation, neutron transport, nuclide burnup and the like of a fuel rod in an extreme environment in a reactor are simulated; and meanwhile, multiple physical states such as temperature, stress, deformation, in-rod pressure, neutron group flux, power, burnup and isotope density of the fuel rod are obtained.