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Self-repairing antibacterial chitosan hydrogel and preparation method thereof

A self-healing, hydrogel technology, applied in the field of biomedicine, can solve problems such as low strength and short service life

Inactive Publication Date: 2021-04-09
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of low mechanical strength and short service life of traditional hydrogels, and provide a self-repairing antibacterial hydrogel and its preparation method

Method used

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  • Self-repairing antibacterial chitosan hydrogel and preparation method thereof

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Effect test

Embodiment 1

[0012] Disperse 2.18 grams of carboxymethyl chitosan powder in 100 milliliters of deionized water, and stir on a magnetic stirrer at room temperature until completely dissolved to obtain a carboxymethyl chitosan solution. Dissolve 1.7 g of gallic acid in 20 ml of ethanol, add an equimolar amount of 1-ethyl-(3-dimethylaminopropyl) carbodiimide salt, stir at room temperature for 10 minutes, then add an equimolar amount of N-hydroxysuccinimide was stirred in an ice-water bath for 1 hour to obtain a mixed solution. Then the above mixed solution was gradually added to the carboxymethyl chitosan solution, stirred in an ice-water bath for 30 minutes, and continued to stir for 24 hours at room temperature. Centrifuge the final reaction solution, wash it repeatedly with ethanol solution, pour it into a dialysis bag and dialyze it with deionized water for 24 hours, and dry it in a vacuum oven to constant weight to obtain a water-soluble carboxymethyl chitosan gallic acid derivative (GA...

Embodiment 2

[0014] Disperse 2.18 grams of carboxymethyl chitosan powder in 100 milliliters of deionized water, and stir on a magnetic stirrer at room temperature until completely dissolved to obtain a carboxymethyl chitosan solution. Dissolve 1.7 g of gallic acid in 20 ml of ethanol, add an equimolar amount of 1-ethyl-(3-dimethylaminopropyl) carbodiimide salt, stir at room temperature for 10 minutes, then add an equimolar amount of N-hydroxysuccinimide was stirred in an ice-water bath for 1 hour to obtain a mixed solution. Then the above mixed solution was gradually added to the carboxymethyl chitosan solution, stirred in an ice-water bath for 30 minutes, and continued to stir for 24 hours at room temperature. Centrifuge the final reaction solution, wash it repeatedly with ethanol solution, pour it into a dialysis bag and dialyze it with deionized water for 24 hours, and dry it in a vacuum oven to constant weight to obtain a water-soluble carboxymethyl chitosan gallic acid derivative (GA...

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Abstract

The invention relates to a self-repairing antibacterial chitosan hydrogel and a preparation method thereof, the self-repairing antibacterial chitosan hydrogel is characterized in that the hydrogel is a self-repairing antibacterial hydrogel, the preparation method of the self-repairing antibacterial hydrogel comprises the following steps of: (1) reacting carboxymethyl chitosan with gallic acid to obtain a soluble carboxymethyl chitosan gallic acid derivative, wherein the molar ratio of gallic acid to carboxyl on carboxymethyl chitosan is 1:1-10:1; and (2) mixing an aqueous solution of the carboxymethyl chitosan gallic acid derivative with a FeCl3 solution according to a concentration ratio of 5:1-20:1 to obtain the self-repairing chitosan hydrogel, wherein the pH value of the mixed solution is 5-10. According to the invention, the intelligent hydrogel with self-repairing performance is synthesized in a short time through the interaction of dynamic metal ligands. In addition, the hydrogel also shows excellent antibacterial performance, and the antibacterial rate is increased along with the increase of the content of the carboxymethyl chitosan gallic acid derivative.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a self-repairing antibacterial hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a polymer gel capable of retaining a large amount of water and biological fluids. It is a soft material with a three-dimensional network structure formed by chemical or physical cross-linking of hydrophilic polymers. Hydrogels have excellent toughness, elasticity and softness, and good biocompatibility, and are widely used in biomedicine, shape memory materials and other fields. Physical hydrogel refers to the hydrogel formed by cross-linking through physical interactions such as hydrogen bonding, metal coordination, electrostatic interaction, host-guest interaction, and hydrophobic interaction. Transition metal ions with empty orbitals (d, f), such as Fe 3+ , Zn 2+ 、Cu 2+ , can be combined with groups with lone pair electrons, such as -COOH, -NH 2 , -OH, resulting in a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08B37/08C08L5/08
CPCC08B37/003C08J3/075C08J2305/08
Inventor 李征征候冰娜
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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