Biological adhesive microsphere with nuclear shell structure and preparation method of microsphere

A technology of bioadhesion and core-shell structure, applied in the field of medicine, can solve the problem of low eradication rate of Helicobacter pylori, achieve the effect of reducing drug loss and good mucosal adhesion

Inactive Publication Date: 2014-10-01
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the oral administration of peptic ulcer, commonly used drug dosage forms have encountered challenges, and the eradication rate of Helicobacter pylori is very low when administered in dosage forms such as tablets and capsules

Method used

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  • Biological adhesive microsphere with nuclear shell structure and preparation method of microsphere
  • Biological adhesive microsphere with nuclear shell structure and preparation method of microsphere
  • Biological adhesive microsphere with nuclear shell structure and preparation method of microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] 1. Preparation of alkaloid ethanol solution

[0080] 1) Crush the raw materials Coptis chinensis and Evodia rutaecarpa, add them to an ethanol solution with a concentration of 60-75% by mass, heat and reflux for extraction 3-5 times, each time for 1.5-2 hours, wherein the weight ratio of Coptis chinensis and Evodia rutaecarpa is 6:1 , the ratio of the total weight of Coptidis Rhizoma and Evodia Fructus to the total volume of ethanol solution in each extraction process is 1:8-12 (g / ml or kg / L), that is, adding ethanol solution 8 -12ml or add 8-12L of ethanol solution to every 1kg of Coptis rhizome and Evodia rutaecarpa mixed raw materials;

[0081] 2) Combine the reflux extracts, concentrate into an extract with a relative density of 1.10-1.30, then place the extract in a freeze dryer (Savant Modulyo D freeze dryer, Thermo company, U.S.) to freeze-dry to constant weight, The total alkaloid extract was obtained.

[0082] In the present invention, besides 6:1, the weight...

Embodiment 2

[0144] 1. In the process of preparing the microsphere core, except that it is different as described below, all the other are the same as in Example 1, specifically as follows:

[0145] 1) The volume ratio of emulsifier Span80 and Tween80 in the mixed emulsion preparation step is 3:1; the ratio of the total volume of emulsifier Span80 and Tween80 to the volume of liquid paraffin is 1:90; the stirring temperature is 50°C;

[0146] 2) The weight ratio of gelatin and sodium alginate in the first carrier solution preparation step is 6:4, and the ratio of the total weight of gelatin and sodium alginate to the volume of the aqueous solution is 10:100 (g / ml), that is, every 100ml The total weight of gelatin and sodium alginate added in the water is 10g;

[0147] 3) In the emulsification treatment step:

[0148] The temperature of the first emulsification treatment is 35°C, the stirring speed is 500rpm, the drop rate of the gelatin-sodium alginate aqueous solution into the mixed emul...

Embodiment 3

[0161] 1. In the process of preparing the microsphere core, except that it is different as described below, all the other are the same as in Example 1, specifically as follows:

[0162] 1) The volume ratio of emulsifier Span80 and Tween80 in the mixed emulsion preparation step is 5:1; the ratio of the total volume of emulsifier Span80 and Tween80 to the volume of liquid paraffin is 1:110; the stirring temperature is 40°C;

[0163] 2) The weight ratio of gelatin and sodium alginate in the first carrier solution preparation step is 8:2, and the ratio of the total weight of gelatin and sodium alginate to the volume of the aqueous solution is 5:100 (g / ml), that is, every 100ml The total weight of the gelatin and sodium alginate added in the water is 5g;

[0164] 3) In the emulsification treatment step

[0165] The temperature of the first emulsification treatment is 55°C, the stirring speed is 300rpm, and the gelatin-sodium alginate aqueous solution is dripped

[0166] The rate ...

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Abstract

The invention relates to a biological adhesive microsphere with a nuclear shell double-layer structure and a preparation method of the microsphere. By taking Zujin pill total alkaloids as a model medicine, taking natural high-molecular polymers such as chitosan, sodium alga acid and gelatin as carrier materials, an intelligent hydrogel medicine release system with biological adhesiveness is constructed. Due to the biological adhesive microsphere with the nuclear shell structure, detention time of the medicine in stomach is prolonged, medicine absorption is increased, and the biological availability of oral medicine for treating gastrohelcosis is improved. The biological adhesive microsphere is a reasonable and effective novel dosage form of gastrohelcosis-resisting medicine developed by using ancient prescription into a modern research method. The invention further illuminates in-vitro medicine release performance of the microsphere and in-vitro biological adhesion effect of the microsphere.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a bioadhesive microsphere of total alkaloids of Zuojin Pills with a shell-core double-layer structure, its preparation method, research on the anti-inflammatory effect of drug prescriptions and its pharmacy research. Background technique [0002] Zuojinwan is a famous prescription derived from Zhu Danxi's "Danxi Heart Method·Fire Six". It is used for distending pain in the ribs caused by excessive fire in the liver meridian, vomiting and acid regurgitation, belching, dry mouth, red tongue with yellow coating, and rapid pulse. etc., it has the functions of clearing liver-fire, lowering adverse flow and relieving vomiting. The original prescription of Zuojin Wan is composed of Coptis chinensis (stir-fried with ginger juice) and Evodia rutaecarpa (or half a liang, soaked in salt water). They are made into water pills or steamed cakes as pills, and taken with white soup. In modern ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/16A61K47/36A61P1/04
Inventor 崔元璐董天骄高秀梅王强松叶磊
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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