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Medicinal composition for treating skin injury and ulcer and application thereof

A composition and drug technology, applied in the direction of drug combination, skin diseases, medical raw materials derived from arthropods, etc., can solve the problems of long disease course, limited clinical promotion and application, and slow onset of effect, so as to promote blood circulation and wound healing. The effect of healing and accelerating regeneration

Inactive Publication Date: 2010-02-17
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the external preparations of traditional Chinese medicine commonly used in clinical practice, such as powder, lotion, plaster, patch, ointment, ointment, etc., mostly simply promote blood circulation and remove blood stasis or antibacterial and anti-inflammatory. Long, which limits its clinical promotion and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Prescription: Chuanxiong 80g, Danshen 30g, Angelica 55g, Paeoniae Alba 80g

[0052] Leech 25g Wood Beetle 25g Collagen 5g

[0053] Preparation method: take the above seven flavors, take Chuanxiong, Danshen and Angelica, add 5 times the amount of 70% ethanol to reflux and extract twice, filter, combine, recover ethanol under reduced pressure, concentrate, dry, crush, and set aside; the obtained medicinal residues are added together with Radix Paeoniae Alba Decoct with 8 times the amount of water twice, 1.5 hours each time, combine the decoction, filter, concentrate under reduced pressure, dry, and set aside. Take 8g of carbomer, add water to swell for 24 hours, add triethanolamine to adjust the pH to 8.0, stir well, add the above dry paste powder and collagen fine powder 5g, add water to 1000g, stir well, remove air bubbles, and make a gel agent.

[0054] Note: Collagen is made from pigskin and fully enzymolyzed with trypsin and neutral pepsin. The relative molec...

Embodiment 2

[0056] Prescription: safflower 120g, achyranthes bidentata 50g, angelica 75g, comfrey 60g

[0057] Motherwort 65g Ground Beetle 30g Curcuma 150g Collagen 18g

[0058] Preparation method: the above-mentioned eight flavors and zedoary are obtained by steam distillation of zedoary volatile oil; safflower, angelica, and comfrey add 4 times the amount of 70% ethanol to reflux and extract twice, filter, combine, recover ethanol under reduced pressure, concentrate, dry, and pulverize , set aside; the obtained dregs, Achyranthes bidentata, motherwort and ground beetle were added to 10 times the amount of water and decocted twice, each time for 2 hours, the decoction was combined, filtered, concentrated under reduced pressure, dried, crushed, and set aside. Separately take 650g of vaseline, 150g of lanolin and appropriate amount of liquid paraffin, heat at 150°C for 1 hour, filter, let cool to 50°C, add zedoary zedoary volatile oil, stir well, then add the above dry cream powder ...

Embodiment 3

[0061] Prescription: Chishao 70g, Leech 25g, Angelica 75g, Chuanxiong 75g

[0062] Panax notoginseng 100g Comfrey 70g Yanhusuo 210g Collagen 15g

[0063] Preparation method: the above eight flavors, Rhizoma Chuanxiong, Angelica, Panax notoginseng, Comfrey and Corydalis add 5 times the amount of 50% ethanol to reflux and extract 3 times, combine, filter, recover ethanol under reduced pressure, concentrate, dry, pulverize, and set aside; the obtained medicine Add 10 times the amount of water to decoct the slag, Radix Paeoniae Rubra and leeches twice, each time for 2 hours, combine the decoction, filter, concentrate under reduced pressure, dry, pulverize, and set aside. Take another collagen solution, add the above-mentioned dry paste fine powder and 15g of sodium carboxymethylcellulose (fully swollen with water), stir well, add water to 1000g, mix in a vibrating ultrafine pulverizer for 20 minutes, and make a gel Glue.

[0064] Note: Collagen is made from pig skin and pi...

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Abstract

The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for activating blood and dissolving stasis such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior common preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald, bedsore, chronic leg ulcer, diabetic foot or cancerous ulcerand the like, and can greatly shorten the required time for wound healing and tissue repair and relieve pains of patients.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating various skin damage and ulcer diseases, which is composed of collagen and traditional Chinese medicines for promoting blood circulation and removing blood stasis, and belongs to the field of traditional Chinese medicines. Background technique [0002] Various diseases characterized by skin damage or ulcers mainly include various types of mechanical trauma, burns, decubitus ulcers, chronic lower ulcers, diabetic foot, cancerous ulcers, etc., because these diseases often cause skin surface defects, resulting in Skin lesions that reach deep into the dermis or deeper are often lingering and difficult to heal, and the course of the disease is long. It is a refractory disease recognized by doctors. At present, there is no ideal treatment plan. Antibacterial drugs (such as gentamicin, chloramphenicol, etc.) combined application, the effect is not good. [0003] The external treatment method o...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K36/906A61K36/73A61K36/71A61K36/66A61K36/537A61K36/533A61K36/486A61K36/30A61K36/286A61K36/258A61K36/236A61K36/232A61K36/21A61P17/02A61K35/62A61K35/64
Inventor 武建卓柴金苗
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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