Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof

Abstract

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS / PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and specifically relates to an antibacterial adhesive injectable hydrogel dressing capable of rapid self-healing, easy extension, and easy compression, and a preparation method and application thereof. Background technique [0002] Skin injury is one of the most common injuries in the human body, such as abrasions, burns, surgical trauma, etc. Unreasonable treatment options often endanger human health, such as causing bacterial infection, tissue dehydration, and even more serious secondary trauma. (X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, P. X. Ma, Biomaterials 2017, 122, 34.) Therefore, designing novel wound dressings has important clinical significance in modern medicine. [0003] Compared with traditional medical dressings, hydrogel medical dressings are a new type of wound dressings developed in recent years. Compared with other types of dressings, its advantages incl...

AI Technical Summary

Problems solved by technology

However, the current common hydrogel dressings usually have the following deficiencies: first, this type of hydrogel obtains antibacterial effects by loading specific antibiotics or specific drugs, and the emergence of some new drug-resistant bacteria, to a certain extent However, this kind of hydrogel lacking inherent antibacterial properties has limited clinical application; (X.Zhao, P.Li, B.Guo, P.X.Ma, ActaBiomaterial 2015, 26, 236.) Second, in human joints, skin is affected The damaged part requires a certain amount of room for movement. Due to its weak mechanical properties, the traditional hydrogel dressing cannot solve the discomfort caused by the patient being bound by the dressing. Even the mechanical force generated by the activity may cause the gel dressing to break or break , and the use time of this type of hydrogel dressing is also greatly reduced; third, because human skin is a weakly acidic environment, traditional hydrogel dressings cannot intelligently control the release of loaded drugs in an acidic environment, and promote wound healing faster process; (Z.Fan, B.Liu, J.Wang, S.Zhang, Q.Lin, P.Gong, L.Ma, S.Yang, Advanced Functional Materials 2014, 24, 3933; N.Annabi, D. Rana, E.Shirzaei Sani, R.Portillo-Lara, J.L.Gifford, M.M.Fares, S.M.Mithieux, A.S.Weiss, Biomaterials 2017, 139, 229.) Fourth, the preparation process of this type of hydrogel is often complicated, the raw materials are expensive, and the operation There are many steps, which also limits its clinical application to a certain extent.

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