Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof

A technology for injecting water and gel, applied in pharmaceutical formulation, pharmaceutical science, drug delivery, etc., can solve the problems of inability to solve patient discomfort, weak mechanical properties, complicated preparation process, etc., and achieves obvious pH response performance, excellent self- Healing properties, rapid drug release effect
CN108912352AActive Publication Date: 2018-11-30XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2018-11-30

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Abstract

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS / PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.
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Description

technical field

[0001] The invention belongs to the technical field of degradable biomedical materials, and specifically relates to an antibacterial adhesive injectable hydrogel dressing capable of rapid self-healing, easy extension, and easy compression, and a preparation method and application thereof. Background technique

[0002] Skin injury is one of the most common injuries in the human body, such as abrasions, burns, surgical trauma, etc. Unreasonable treatment options often endanger human health, such as causing bacterial infection, tissue dehydration, and even more serious secondary trauma. (X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, P. X. Ma, Biomaterials 2017, 122, 34.) Therefore, designing novel wound dressings has important clinical significance in modern medicine.

[0003] Compared with traditional medical dressings, hydrogel medical dressings are a new type of wound dressings developed in recent years. Compared with other types of dressings, its advantages incl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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