Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof

A technology for injecting water and gel, applied in pharmaceutical formulation, pharmaceutical science, drug delivery, etc., can solve the problems of inability to solve patient discomfort, weak mechanical properties, complicated preparation process, etc., and achieves obvious pH response performance, excellent self- Healing properties, rapid drug release effect

Active Publication Date: 2018-11-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current common hydrogel dressings usually have the following deficiencies: first, this type of hydrogel obtains antibacterial effects by loading specific antibiotics or specific drugs, and the emergence of some new drug-resistant bacteria, to a certain extent However, this kind of hydrogel lacking inherent antibacterial properties has limited clinical application; (X.Zhao, P.Li, B.Guo, P.X.Ma, ActaBiomaterial 2015, 26, 236.) Second, in human joints, skin is affected The damaged part requires a certain amount of room for movement. Due to its weak mechanical properties, the traditional hydrogel dressing cannot solve the discomfort caused by the patient being bound by the dressing. Even the mechanical force generated by the activity may cause the gel dr

Method used

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  • Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof
  • Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof
  • Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof

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preparation example Construction

[0059] A method for preparing an antibacterial adhesive injectable hydrogel dressing with fast self-healing, easy extension, and easy compression disclosed by the present invention comprises the following steps:

[0060] (1) Preparation of QCS (Quaternized chitosan, quaternized chitosan) polymer:

[0061]Dissolve chitosan in deionized water first, then add glacial acetic acid dropwise while stirring, react at 55°C for 10-300 minutes, then add 2,3-epoxypropyltrimethylammonium chloride, React at 60°C for 12-36 hours, centrifuge the reaction solution at a speed of 2000-6000r / min for 10-30 minutes to obtain a supernatant, add 5-8 times the volume of acetone, the precipitation is complete, and finally filter and dry to obtain a quaternized ammonium shell Polysaccharide polymer; wherein, the mass ratio of chitosan and 2,3-epoxypropyltrimethylammonium chloride is (1-6): (0.5-6).

[0062] (2) PF127-CHO (Benzaldehyde-terminated PF127, aldehyde-terminated F127) the preparation of pol...

Embodiment 1

[0086] 1) Preparation of QCS (Quaternized chitosan, quaternized chitosan) polymer: first dissolve 0.5g chitosan in deionized water, then add glacial acetic acid dropwise while stirring, react at 55°C for 180 minutes, and then Add 0.873g of 2,3-epoxypropyltrimethylammonium chloride, react at 55°C for 18 hours, centrifuge the reaction solution at a speed of 4000r / min for 10 minutes to obtain a supernatant, add 5 times the volume of acetone, and the precipitation is complete. Finally, suction drying is obtained to obtain a quaternized chitosan polymer;

[0087] 2) PF127-CHO (Benzaldehyde-terminated PF127, aldehyde-terminated F127) Preparation of polymers:

[0088] (1) put 25g The F127 polymer was sealed in a three-necked flask and dried under vacuum at 90°C for 12 hours, then 200 mL of dry dichloromethane was added, and 2.7 mL of dry triethylamine was added in an ice bath at 0°C, and stirred thoroughly for 10 minutes, and then 16.68 g was dried The methanesulfonyl chloride w...

Embodiment 2

[0092] Different from Example 1, the aldehyde group-terminated in step 3) The F127 polymer solution was replaced with 500mg / mL, 400mg / mL, 360mg / mL, 300mg / mL and 150mg / mL respectively, and the crosslinking time was 15 seconds, 20 seconds, 30 seconds, 55 seconds, 120 seconds, respectively named as QCS / PF1.7, QCS / PF1.3, QCS / PF1.2, QCS / PF1.0, QCS / PF0.5.

[0093] Tested as Figure 8 As shown, when the PF-CHO polymer solution is 400mg / mL, 360mg / mL, 300mg / mL, 240mg / mL respectively, the hydrogel shows a moderate storage modulus, indicating that it has good stability;

[0094] Therefore, in the present invention, the aldehyde-terminated The concentration of the F127 polymer solution is 150-500 mg / mL.

[0095] In the step (3), the quaternized chitosan solution is prepared with a phosphate buffered saline solution, the mass concentration is 20-70 mg / mL, and the aldehyde group-capped F127 polymer solution is prepared with phosphate buffered saline solution, the mass concentration i...

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Abstract

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS/PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and specifically relates to an antibacterial adhesive injectable hydrogel dressing capable of rapid self-healing, easy extension, and easy compression, and a preparation method and application thereof. Background technique [0002] Skin injury is one of the most common injuries in the human body, such as abrasions, burns, surgical trauma, etc. Unreasonable treatment options often endanger human health, such as causing bacterial infection, tissue dehydration, and even more serious secondary trauma. (X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, P. X. Ma, Biomaterials 2017, 122, 34.) Therefore, designing novel wound dressings has important clinical significance in modern medicine. [0003] Compared with traditional medical dressings, hydrogel medical dressings are a new type of wound dressings developed in recent years. Compared with other types of dressings, its advantages incl...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08B37/08A61L26/00
CPCA61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/232A61L2300/404A61L2400/04A61L2400/06C08B37/003C08J3/075C08J3/246C08L5/08C08L71/02
Inventor 郭保林屈锦赵鑫梁永平
Owner XI AN JIAOTONG UNIV
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