The invention relates to the field of biological medicine and specifically relates to a compound for hormonous dermatitis, a preparation, a preparation method and an application thereof. The compound comprises the following components: rose hydrosol, grape seed extract, aloe vera gel, liquorice extracting solution, curcumin, apigenin, oat-beta-glucan, amidogen glucan, water-soluble azone, polylysine, water soluble vitamin E, buxus chinensis, 1,2-glutaraldehyde, compound growth factor, hydroxypropyl-beta-cyclodextrin, EDTA-2Na, collagen, humectants, auxiliary material and natural preservatives. The components in the compound have mild action to skin and are free from irritation; the components are collocated with each other, can prevent inflammation and anaphylaxis caused by hormonous dermatitis on the basis of supplying moisture preservation and can restrain bacteria to infect the damaged skin. The added compound growth factor can promote metabolism and repairing of cells of corium layer, epidermis and especially cuticle and can promote the forming of intercellular substance, so as to repair the damaged skin and achieve the effects of protection and curing.