9results about How to "Regulate immune response" patented technology

The invention relates to the technical field of biological medicine, in particular to a nano-enzyme antibacterial coating for the surface of an implant and a preparation method and application of the nano-enzyme antibacterial coating. The invention provides a Fe / MSAC nano-composite used on the surface of an implant, the Fe / MSAC nano-composite is prepared by wrapping hyaluronic acid and a macrophage membrane with FeSAC containing iron monatomic catalytic sites, the Fe / MSAC nano-composite is used on the surface of the implant, is safe and stable, reduces toxic and side effects on an organism when no bacteria exist, and can be used for preparing the implant. In addition, staphylococcus aureus can be effectively killed in the presence of bacteria, the formation of a biofilm is inhibited, meanwhile, the immune response of a body is regulated, and the effect of preventing infection is achieved.

The invention provides a composition with a whitening effect as well as a preparation method and application thereof. The composition comprises the following raw materials in percentage by mass: 2-10% of polyhydric alcohol; 2-15% of grease; 0.1-1% of a thickening agent; 0.1-2% of an emulsifier; 1-5% of nicotinamide; 0-3% of 3-o-ethyl ascorbic acid; 0 to 0.4 percent of phenylethyl resorcinol; 0 to 1% of alpha-arbutin; 0-0.5% of a plant whitening compound II; 10% to 0.5% of nonapeptide-10%; 0 to 0.5% of tocopheryl acetate; 0 to 0.5 percent of inositol; 0-0.5% of a purslane extract; 0 to 0.5 percent of bisabolol; and the balance water. According to the composition with the whitening effect, through synergistic interaction of multiple components, the whitening effect is good, and meanwhile, the composition has the anti-allergy and soothing effects.

Disclosed herein are methods of treating hematological malignancies (e.g., acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or acute lymphoblastic leukemia (ALL)) using an antigalectin-9 antibody (e.g., G9.2-17 (IgG4)). In some embodiments, the anti-galectin-9 antibody is used as a monotherapy.

The invention relates to application of a dietary fiber probiotic composition, in particular to application of a composition of ganoderma lucidum dietary fibers and lactobacillus fermentum CEC-T5716 in preparation of drugs or health care products for preventing or relieving constipation. The constipation symptom can be effectively improved by influencing the weight of mice, the first black stool time, the excrement water content, the small intestine propulsion rate, the colon tissue state, colon tissue aquaporin, the intestinal barrier, inflammatory factor related genes and excrement intestinal flora expression and adjusting the short-chain fatty acid content in cecum contents; the symptoms of dry and hard excrement, prolonged defecation time and the like caused by constipation are relieved, the intestinal peristalsis capability of mice with constipation can be promoted, and the damage of constipation to intestinal tracts is relieved.

The invention relates to an antibody for binding with human GP130 and application thereof. In a heavy chain variable region of the antibody, VHCDR1 is selected from an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2; the VHCDR2 is selected from an amino acid sequence as shown in SEQ ID NO: 3; the VHCDR3 is selected from an amino acid sequence as shown in SEQ ID NO: 4, SEQ ID NO: 5 or SEQ ID NO: 6; the light chain variable region comprises an amino acid sequence as shown in SEQ ID NO: 7; the antibodies are capable of specifically binding to human GP130 to impede binding of human IL-6 to the human IL-6 receptor. According to the scheme provided by the invention, the human GP130 can be bound in a targeted manner, and the binding of IL-6 and a receptor thereof is specifically blocked, so that abnormal immune response is regulated, and inflammation signals in a pathological process are inhibited.

This invention discloses a method for preparing purslane exosomes with anti-allergic effects and their applications, specifically relating to the field of natural active substances. The method includes washing fresh purslane and then juicing or homogenizing it, separating solid residue from the liquid juice to obtain a plant homogenate supernatant as a precursor. The precursor is then subjected to low-temperature differential centrifugation to remove cell debris and large particulate impurities, and the clarified supernatant is collected. The clarified supernatant is then filtered through one or more multi-stage filter membranes, with pore sizes selected from 5 μm, 1.2 μm, 0.45 μm, 0.22 μm, and 100 nm. Through optimized extraction processes, such as specific enzymatic hydrolysis steps, centrifugation conditions, and ultrafiltration technology, the extraction efficiency and purity of exosome-like nanovesicles are significantly improved. Compared to traditional extraction methods, this method can more accurately remove impurities, preserve the integrity and bioactivity of exosome-like nanovesicles, and ensure their stability and effectiveness in subsequent applications.

The invention relates to application of an LAPTM5 molecule as a target spot in developing or screening or preparing a medicine for preventing and / or treating inflammatory skin diseases. The invention discloses the application of the LAPTM5 as a target spot in the aspect of treating rosacea for the first time, and particularly, the LAPTM5 realizes a treatment effect by positively regulating the activity of STING protein. Although the research of the LAPTM5 in the aspect of treating cancers exists, the research of the LAPTM5 on the STING-mediated inflammation regulation is still blank, and the participation of LAPTM5 and STING signal pathways in inflammatory dermatosis is not reported, especially in the aspect of inflammation such as rosacea and the like. The molecular mechanism of the LAPTM5 for regulating and controlling the STING signal channel is clarified, and a new thought is provided for researching the pathogenesis of the skin inflammation reaction. Aiming at the defect of limited treatment effect of rosacea in the past, the treatment target provided by the invention can bring a more effective treatment scheme so as to improve symptoms and life quality of patients.

This invention provides a high-throughput and efficient method for screening multiple target genes that can regulate mRNA expression levels in cells by co-transfecting or sequentially transfecting mRNA with a gene silencing library targeting genes in cells using lipid nanoparticles. Several target genes that can regulate mRNA protein expression levels through the action of siRNA have been discovered. By manipulating these genes that regulate mRNA expression levels, the translational capacity of mRNA in mRNA vaccine and drug development can be improved, mRNA protein expression efficiency can be increased, and immunogenicity and toxicity can be reduced.

The invention relates to the field of cosmetic raw materials, and particularly discloses a ganoderma sinensis extract and a preparation method thereof. The ganoderma sinensis extract is prepared from the following components in parts by mass: 0.01 to 0.5 part of polysaccharide, 0.05 to 0.5 part of triterpenoids, 0.05 to 0.5 part of protein and 0.01 to 0.5 part of polypeptide. The preparation method comprises the following steps: crushing and sieving Ganoderma sinensis to obtain Ganoderma sinensis micro-powder, and performing micro-pressure treatment on the Ganoderma sinensis micro-powder; mixing the Ganoderma sinensis particles with pure water to obtain a mixed solution, and stirring the mixed solution at normal temperature; after soaking, heating the mixed solution, preserving heat and extracting; carrying out rough filtration and fine filtration on the mixed solution through a filter material after the heat preservation is finished; concentrating the filtrate, and mixing with a redissolving solvent; and filtering the concentrated product under reduced pressure, and heating and sterilizing the product to obtain the ganoderma sinensis extract. The ganoderma sinensis extract disclosed by the invention can be applied to cosmetics and has the advantages of resisting wrinkles and tightening; the preparation method has the advantages of simple process and high product purity.