Application of tauroursodeoxycholic acid salt used as active ingredient in preparation of drug for treating echinococcosis

A technology for echinococcosis granulosus and deoxycholate, which is applied in the field of pharmaceutical effects and biological effects of tauroursodeoxycholate, and can solve the problems of cell damage, variable pharmaceutical effects, liver failure and the like

Inactive Publication Date: 2015-03-04
姜玉峰
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  • Abstract
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Problems solved by technology

Therefore, on the whole, extravasation of the scoliosis and improper handling of the scoliosis during surgery are insurmountable defects in the surgical treatment of cystic echinococcosis.
[0003] For the problems referred to above, this area tries to adopt high-concentration acidic (HCl) and alkaline solution (KOH) in vitro, and the local chemotherapeutic drug commonly used in clinic has 20% hypertonic saline, but has certain destructive effect to surrounding normal liver tissue; Studies in the field have also found that bile can inh

Method used

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  • Application of tauroursodeoxycholic acid salt used as active ingredient in preparation of drug for treating echinococcosis
  • Application of tauroursodeoxycholic acid salt used as active ingredient in preparation of drug for treating echinococcosis
  • Application of tauroursodeoxycholic acid salt used as active ingredient in preparation of drug for treating echinococcosis

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Embodiment Construction

[0022] In order to illustrate the application effect of tauroursodeoxycholate (TUDCA), the applicant has carried out an in vitro experiment to illustrate the killing effect of tauroursodeoxycholate on the protoscole of Echinococcus granulosus, and the applicant has carried out Experiments described below. Experiment 1: The effect of TUDCA on the protoscole of Echinococcus granulosus in vitro

[0023] Take fresh liver of sheep naturally infected with Echinococcus granulosus, clean the surface of sheep liver, disinfect the surface with 75% alcohol, extract the cyst fluid containing protoscoleum under aseptic conditions, and transfer it into a sterile bottle. The protoscolm was washed with PBS (PH=7.2) for 3 times until clarified, and the dye rejection test was performed with 0.1% eosin dye solution, and the dye rejection was over 98%. The protoscole was observed with the naked eye as fine white sand-like uniform particles, and the protoscole with good activity had a fast sedime...

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Abstract

The invention discloses application of tauroursodeoxycholic acid salt used as an active ingredient in preparation of a drug for treating echinococcosis. The tauroursodeoxycholic acid salt is used as the active ingredient for killing pathogen-echinococcus granulosus of the echinococcosis; an obvious echinococcosis protoscolex restraining and killing effect is achieved, and thus, the treatment of the echinococcosis is realized.

Description

technical field [0001] The invention relates to the pharmaceutical effect and biological effect of tauroursodeoxycholate, belonging to the field of medicinal chemistry. Background technique [0002] Echinococcus granulosus (Echinococcus granulosus, Eg), also known as cystic echinococcosis (CE), is caused by the middle-stage larvae of Echinococcus granulosus (Eg) Zoonotic parasitic diseases for health and livestock development. The disease is distributed globally and is mainly prevalent in Xinjiang, Qinghai, Inner Mongolia, Tibet and other provinces with developed animal husbandry in my country. Cystic echinococcosis primarily affects the liver, but can also develop in the lungs. At present, the treatment for this disease is mainly a surgical method, that is, complete resection of the outer and outer capsules of the hepatic hydatid adventitia. Although the complete excision of the outer and outer capsules of the hepatic hydatid cysts adopted in recent years can greatly red...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P33/10
CPCA61K31/575Y02A50/30
Inventor 姜玉峰吕海龙孙冯
Owner 姜玉峰
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