Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus

A technology of composite latex and guar gum, applied in the field of medicine, can solve the problems of unsatisfactory antipruritic and swelling effects, toxic and side effects, and short action time, and achieve the effect of strong plasticity, small toxic and side effects, and long action time

Inactive Publication Date: 2013-10-09
CHONGQING MJ MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antipruritic effect mainly has the following limitations: short action time, unsatisfactory antipruritic and swelling effect, and relatively large toxic and side effects

Method used

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  • Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus
  • Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus
  • Macromolecular compound latex scar paste applied to inhibiting discomforts such as pruritus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 1L of 1mmol / L boric acid at 25°C, add 1mmol / L NaOH, and stop adding when the pH is adjusted to 11 with a pH meter during the addition. After 10 minutes of reaction, add 50g of guar gum, and react at 25°C for half an hour to obtain melon glue gel.

[0033] Mix 20g of chitosan and 10g of methyl acrylate into 50ml of distilled water, act on an ultrasonic breaker at 750w for 30min, ultrasonically disperse for 5 minutes (300w), continue stirring at 30°C for 9 hours, and dry in vacuum at 50°C to obtain polymethylacrylate - Chitosan nanocomposite powder.

[0034] Add 30 g of prepared polymethyl acrylate-chitosan nanocomposite powder into 50 g of guar gum hydrogel, add methyl salicylate 17.5 g, heparin sodium 40IU, allantoin 1 g, menthol 0.5 g, camphor 0.5g, 0.5g borneol, stirring continuously for 3 hours, put the mixed gel in a 40°C incubator for 3 days, take the cured gel as scar sticker (ie composite latex scar sticker).

Embodiment 2

[0036] Take 1L of 1mmol / L boric acid at 25°C, add 1mmol / L NaOH, and stop adding when the pH is adjusted to 11 by a pH meter during the addition. After 10 minutes of reaction, add 50g of guar gum, and react at 25°C for half an hour to obtain guar gum water gel.

[0037] Mix 30g of chitosan and 15g of methyl acrylate into 50ml of distilled water, act on an ultrasonic breaker at 750w for 30min, ultrasonically disperse for 5 minutes (300w), stir and react at 30°C for 8 hours, and dry in vacuum at 50°C to obtain polymethylacrylate - Chitosan nanocomposite powder.

[0038] Add 42 g of the prepared polymethyl acrylate-chitosan nanocomposite powder into 50 g of guar gum hydrogel, add methyl salicylate 6 g, heparin sodium 50 IU, allantoin 1 g, and borneol 1 g at the same time, and continue stirring for 3 hours , put the mixed gel into an incubator at 40°C for 3 days, and take the cured gel as scar paste glue (ie composite latex scar paste).

Embodiment 3

[0040]Take 1L of 1mmol / L boric acid at 25°C, add 1mmol / L NaOH, and stop adding when the pH is adjusted to 11 with a pH meter during the addition. After 10 minutes of reaction, add 50g of guar gum, and react at 25°C for half an hour to obtain melon glue gel.

[0041] Mix 20g of chitosan and 10g of methyl acrylate into 50ml of distilled water, act on an ultrasonic breaker at 750w for 30min, ultrasonically disperse for 5 minutes (300w), continue stirring at 30°C for 9 hours, and dry in vacuum at 50°C to obtain polymethylacrylate - Chitosan nanocomposite powder.

[0042] The prepared polymethyl acrylate-chitosan nanocomposite powder 30g is added in the guar gum hydrogel 52g, adds methyl salicylate 14.5g, allantoin 2g, borneol 1.5g simultaneously, continues to stir 4 hours, will The mixed gel was put into an incubator at 40° C. for 3 days, and the cured gel was taken as scar paste glue (ie composite latex scar paste).

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Abstract

The invention discloses a macromolecular compound latex scar paste used for controlling subjective discomforts such as local pruritus and fever caused by hypertrophic scar after wound healing of burn. The latex comprises the following components of hydroxypropyl guar gum powder, polymethyl methacrylate-chitin, methyl salicylate, heparin sodium, allantoin, menthol, camphor and borneol. Animal experiments and human body tests verify that the macromolecular compound latex (scar paste) is exact in itch-relieving effect, and can be used for controlling subjective discomforts such as local pruritus and fever caused by hypertrophic scar.

Description

technical field [0001] The invention relates to a polymer composite latex plaster used for controlling subjective discomfort symptoms such as local itching and fever caused by hypertrophic scar after burn wound healing, and belongs to the technical field of medicine. Background technique [0002] The skin is the largest organ of the human body and an important natural barrier to protect the body. Some pruritus diseases of the skin in life often bother patients and seriously affect the quality of life of patients. The so-called pruritus is an unpleasant sensation on the skin or mucous membranes that causes the desire to scratch. There are many reasons to cause skin itching. For example, for patients with severe skin defects such as large areas of deep second-degree and third-degree burns, severe hypertrophic scars may cause severe itching after wound healing; Each has its own etiology and pathogenesis, such as hypersensitivity, dry skin, hyposecretion of sebaceous glands, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/618A61K31/727A61K47/36A61K47/32A61P17/02A61P17/04A61P29/00A61K31/4166A61K31/125A61K31/045
Inventor 吴军徐瑞罗高兴詹日兴夏和生
Owner CHONGQING MJ MEDICAL DEVICES
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