Microneedle patch for scar treatment and preparation method thereof

A micro-needle sticker and scar technology, applied in the field of biomedicine, can solve the problems of difficult penetration of drugs, dysfunction of the stratum corneum, severe pain in patients, etc., and achieve the effects of convenient use and good stability.

Inactive Publication Date: 2021-06-22
上海行渝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, multi-point injection of drugs in the scar, even if used under local anesthesia, will still cause severe pain to the patient, resulting in low patient compliance
Moreover, the multi-point injection method has high requirements on the operation skills of medical personnel. If the drug distribution is uneven due to poor skills, it will often cause a variety of adverse reactions.
Another commonly used method is to apply medicine on the surface of the scar, which can be operated by the patient himself, which is very convenient. However, due to the dysfunction of the stratum corneum and the thickening of the dermis at the scar, it is difficult for the medicine to penetrate, resulting in longer treatment time and poor treatment effect.

Method used

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  • Microneedle patch for scar treatment and preparation method thereof
  • Microneedle patch for scar treatment and preparation method thereof
  • Microneedle patch for scar treatment and preparation method thereof

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Experimental program
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preparation example Construction

[0035]

[0036] Such as figure 1 and figure 2 As shown, the preparation method of the microneedle patch for scar treatment of the present invention comprises the following steps:

[0037] (1) Preparation of needle solution: uniformly disperse the anti-scar active ingredient and matrix material into pure water to obtain needle solution A;

[0038] (2), preparation of the base solution: uniformly disperse the base material into pure water to obtain the base solution B;

[0039] (3), preparation of the needle body: take the needle body solution A and add it to the microneedle mold, centrifuge, so that the needle body solution A is completely filled in the cavity of the microneedle mold, and recover the excess needle body solution A;

[0040] (4), preparation of the substrate: adding the substrate solution B to the microneedle mold treated in step (3), centrifuging again, so that the substrate solution B evenly fills the substrate of the microneedle mold;

[0041] (5) Drying...

Embodiment 1

[0051] The preparation method of the microneedle patch for scar treatment of the present embodiment comprises the following steps:

[0052] (1) Preparation of needle solution: uniformly disperse anti-scar active ingredients (1.0g onion extract, 0.03g allantoin, 0.015g heparin sodium) and matrix material (1.5g hyaluronic acid) into 10mL pure water , that is, needle solution A is obtained;

[0053] (2) Preparation of the base solution: uniformly disperse the base material (1.5 g of hyaluronic acid) into 10 mL of pure water to obtain the base solution B;

[0054] (3) Preparation of the needle body: Take the needle body solution A and add it to the microneedle mold, and centrifuge for the first time at a speed of 3500rpm, a temperature of 4°C, and a centrifugation time of 5min, so that the needle body solution A is completely filled to the microneedle In the cavity of the mould, recover excess needle solution A;

[0055] (4) Preparation of the substrate: Add the substrate soluti...

Embodiment 2

[0058] The preparation method of the microneedle patch for scar treatment of the present embodiment comprises the following steps:

[0059] (1), preparation of needle solution: anti-scar active ingredients (0.8g onion extract, 0.2g cannabis leaf extract, 0.03g allantoin, 0.015g heparin sodium) and matrix material (0.75g polyvinyl alcohol, 0.75g polyvinylpyrrolidone) was uniformly dispersed in 10mL pure water to obtain needle solution A;

[0060] (2) Preparation of the base solution: uniformly disperse the base material (0.75 g polyvinyl alcohol, 0.75 g polyvinyl pyrrolidone) into 10 mL of pure water to obtain the base solution B;

[0061] (3) Preparation of the needle body: Take the needle body solution A and add it to the microneedle mold, and centrifuge for the first time at a speed of 3500rpm, a temperature of 4°C, and a centrifugation time of 5min, so that the needle body solution A is completely filled to the microneedle In the cavity of the mould, recover excess needle ...

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Abstract

The invention provides a microneedle patch for scar treatment and a preparation method thereof, the microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, the needle body comprises an anti-scar active component and a matrix material, the anti-scar active component comprises onion extract, cannabis sativa leaf extract, allantoin and heparin sodium in a mass ratio of 1: (0-1): (0-0.5): (0-0.02); the anti-scar active component mainly comprises an onion extract, the substrate also comprises a matrix material, and the matrix material comprises but not limited to hyaluronic acid, sodium hyaluronate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, sodium carboxymethyl cellulose, hydroxypropyl-beta-cyclodextrin, sodium alginate, polylactic acid, chitosan and glucan; the microneedle patch for scar treatment has certain mechanical strength, is convenient to use and good in stability, can realize minimally invasive painless effect when acting on skin, and provides a new and effective method for treatment of hypertrophic scars at any part of a body.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a microneedle patch for scar treatment and a preparation method thereof. Background technique [0002] Hypertrophic scars are usually pathological scars caused by excessive body repair during the wound healing process. In essence, scar fibroblasts proliferate excessively, collagen synthesis increases, fibronectin and mucopolysaccharides and other extracellular matrix accumulate during skin repair. Caused by excessive deposition and disordered arrangement. Hypertrophic scars are located on the surface of the skin, often manifested as swelling, inflammation, and redness, accompanied by symptoms such as tingling and itching, which will bring both physical and psychological distress to patients. [0003] Clinical treatments for hypertrophic scars include surgery, drug therapy, compression therapy, radiotherapy, and laser. Among them, multi-point injection of drugs i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/00A61K47/10A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61M37/00A61P17/02A61K31/4166A61K31/727A61K36/60
CPCA61K36/8962A61K36/60A61K31/4166A61K31/727A61K9/0021A61K47/36A61K47/32A61K47/10A61K47/38A61K47/40A61K47/34A61P17/02A61M37/0015A61M2037/0053A61K2300/00
Inventor 宋杰叶睿江凯
Owner 上海行渝生物科技有限公司
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