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Microneedle for hypertrophic scars and preparation method for microneedle

A hypertrophic scar and microneedle technology, applied in the field of biomedicine, can solve problems such as toxic reaction tissue and rejection

Active Publication Date: 2015-11-11
海南德拉米克投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] A microneedle is a needle-like projection with a length between 50 and 900 microns, which realizes transdermal drug delivery by puncturing the skin, and it only pierces the stratum corneum of the skin without hurting the nerves during the puncture process. Therefore, it will not cause pain or skin damage; the materials currently used to make microneedles mainly include metals, monocrystalline silicon, polymers and sugars; soft, while the scar tissue epidermis is hard and the fibrous layer is thick, so it is difficult to directly penetrate into the hyperplastic tissue layer; although metal or monocrystalline silicon microneedles are hard, they are prone to break and stay in the body causing various Toxic reactions and tissue rejection problems

Method used

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  • Microneedle for hypertrophic scars and preparation method for microneedle
  • Microneedle for hypertrophic scars and preparation method for microneedle

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preparation example Construction

[0026] The invention provides a method for preparing microneedles for hypertrophic scars, comprising:

[0027] 1) mixing the first polymer with the first solvent to obtain the first solution,

[0028] The first polymer is a crystalline polymer;

[0029] mixing a second polymer with a second solvent to obtain a second solution;

[0030] 2) pouring the first solution into a mold containing the micropore array, and vacuuming to obtain a mold filled with the micropores of the first solution;

[0031] 3) Adding the second solution into the mold with micropores filled with the first solution, and vacuuming to obtain microneedles for hypertrophic scars.

[0032] According to the present invention, the present invention mixes the first polymer with the first solvent to obtain the first solution; wherein, the first polymer is preferably poly-L-lactic acid, poly-D-lactic acid, polyhydroxybutyl ester homopolymer and One or more of the polyhydroxybutyrate pentyl ester copolymers, more ...

Embodiment 1

[0042] The crystalline polymer PLLA (0.5g) was used as a solute, and it was fully dissolved in a mixed solution of 12g of dichloromethane and 8g of 1,4-dioxane to prepare the first solution;

[0043] 0.5g PLGA and 15g dichloromethane solution were mixed to obtain a second solution;

[0044] 5g of the first solution is evenly poured on the porous ceramic microporous abrasive tool, immediately put into a downward vacuuming device, and vacuumize to ensure that the solution penetrates into the ceramic abrasive tool, and obtain a micropore-filled mold of the first solution;

[0045] Take out the mold filled with the micropores of the first solution, continue to pour several mL of the second solution evenly, and immediately put it into a porous ceramic device that is evacuated downward, the solvent evaporates, and after it is completely dried, a microneedle patch for hypertrophic scars is obtained. .

[0046] Immerse the microneedles for hypertrophic scars into the aqueous solution...

Embodiment 2

[0049] A crystalline polymer polyhydroxybutyrate homopolymer (0.4 g) was used as a solute, and it was fully dissolved in a mixed solution of 12 g of methylene chloride and 8 g of 1,4-dioxane to prepare a first solution;

[0050] 0.2g PLGA and 15g dichloromethane solution were mixed to obtain a second solution;

[0051] 5g of the first solution is evenly poured on the porous ceramic microporous abrasive tool, immediately put into a downward vacuuming device, and vacuumize to ensure that the solution penetrates into the ceramic abrasive tool, and obtain a micropore-filled mold of the first solution;

[0052] Take out the mold filled with the micropores of the first solution, continue to pour 5mL of the second solution evenly, and immediately put it into a porous ceramic device that is vacuumed downwards, the solvent evaporates, and after it is completely dried, a microneedle patch for hypertrophic scars is obtained.

[0053] Immerse the microneedles for hypertrophic scars into t...

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Abstract

The invention provides a microneedle for hypertrophic scars and a preparation method for the microneedle. The preparation method comprises the following steps of adopting crystalline macromolecules which serve as first polymers, casting a first solution into a die with a micropore array, and performing vacuumizing to obtain a die of which micropores are filled with the first solution; adding a second solvent into the die of which the micropores are filled with the first solution, and performing vacuumizing to obtain the microneedle for hypertrophic scars. Therefore, the prepared microneedle is hard enough to penetrate through scar tissues, and moreover, a water-soluble medicament as well as an oil-soluble medicament can be supported by the microneedle.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a microneedle for hypertrophic scars and a preparation method thereof. Background technique [0002] Hypertrophic scars in skin and other tissues have caused a series of obstacles to patients in terms of frontal function, appearance, and heart, and hypertrophic scars have always been a difficult problem in surgical treatment. [0003] At present, the methods for reducing scars are mainly: local application, drug injection or biomechanical methods; among them, topical external application and transdermal administration are convenient, painless, long-term stable delivery speed, and low drug toxicity. Side effects, avoiding the influence of the gastrointestinal environment on drug efficacy and the first-pass effect of the liver, etc. However, due to the special tissue structure of hypertrophic scars: thickened stratum corneum and hyperplastic dermis, drugs cannot enter the scar at all. R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/02A61L31/00A61L31/04A61L31/16
Inventor 崔文国费健张俊程若昱朱彩虹过倩萍张文
Owner 海南德拉米克投资有限公司
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