Wound dressing and preparation method thereof

A wound dressing and product technology, applied in dressings, non-adhesive dressings, medical science and other directions, can solve the problems of lack of moisturizing function, easy dehydration of the wound surface and high permeability, so as to accelerate the proliferation of cells and keep the wound surface moist and uniform. good effect

Inactive Publication Date: 2016-07-20
GUANGZHOU DIANFANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings such as gauze and bandages have large gaps and high permeability, which makes the wound surface dehydrated easily and does not have moisturizing function

Method used

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  • Wound dressing and preparation method thereof
  • Wound dressing and preparation method thereof
  • Wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a silicone-nanofiber multilayer wound dressing, comprising the following steps:

[0028] (1) Prepare 15g of mixed solution with silicone prepolymer, liquid paraffin, n-hexane, and Span-80 according to the mass ratio of 25:3:70:2, and stir evenly. After vacuum defoaming, pour polytetrafluoroethylene In the vinyl mold, after uniform casting, vacuum drying at 50°C for 4 hours to obtain a silicone film; soak the silicone film in ethanol for 15 hours to remove the paraffin wax components in the silicone film, such as figure 2 As shown, a silicone membrane with a microporous structure is obtained;

[0029] (2) Dissolve PLA with Mw=90KDa in a mixed solvent of N,N-dimethylacetamide and acetone (1:1, v:v) with a mass fraction of 14%, heat to dissolve at 50°C, and let stand Degassing to obtain PLA electrospinning solution;

[0030] (3) Adhere the silicone film to the aluminum foil and fix it on the roller receiver of the electrospinning machine; load th...

Embodiment 2

[0033] A preparation method of a silicone-nanofiber multilayer wound dressing, comprising the following steps:

[0034] (1) Prepare 15g of mixed solution with silicone prepolymer, liquid paraffin, n-hexane, and Span-80 according to the mass ratio of 20:4:75:1, and stir evenly. After vacuum defoaming, pour polytetrafluoroethylene In the vinyl mold, after uniform casting, vacuum dry at 60°C for 3 hours to obtain a silicone film; soak the silicone film in ethanol for 24 hours to remove the paraffin wax component in the silicone film to obtain a silicone film with a microporous structure ;

[0035] (2) Dissolve PLGA with Mw=90KDa in a mixed solvent of chloroform and acetone (3:2, v:v) according to the mass fraction of 24%, heat and dissolve at 40°C, and let stand for defoaming to obtain PLGA electrospinning solution ;

[0036] (3) Adhere the silicone film to the aluminum foil and fix it on the roller receiver of the electrospinning machine; load the PLGA solution into the syring...

Embodiment 3

[0039] A preparation method of a silicone-nanofiber multilayer wound dressing, comprising the following steps:

[0040] (1) Prepare 20g of mixed solution with silicone prepolymer, liquid paraffin, n-hexane, and Span-80 according to the mass ratio of 22:1:74:3, and stir evenly. After vacuum defoaming, pour polytetrafluoroethylene In the vinyl mold, after uniform casting, vacuum dry at 45°C for 6 hours to obtain a silicone film; soak the silicone film in ethanol for 10 hours to remove the paraffin wax component in the silicone film to obtain a silicone film with a microporous structure ;

[0041] (2) Dissolve PCL with Mw=150KDa in a mixed solvent of glacial acetic acid and acetone (2:3, v:v) according to the mass fraction of 21%, heat and dissolve at 40°C, and let stand for defoaming to obtain PCL electrospun liquid;

[0042](3) Adhere the silicone film to the aluminum foil and fix it on the roller receiver of the electrospinning machine; load the PCL solution into the syringe...

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Abstract

Provided are a wound dressing and a preparation method thereof.The wound dressing is composed of a silicone membrane layer and an electrospun nanofiber layer.The preparation method comprises the steps that silicone, liquid paraffin, normal hexane and span-80 are mixed to be uniform, the mixed solution is cast in a polytetrafluoroethylene mold through a membrane casting method, after a membrane is formed through drying, a silicone membrane is soaked in ethyl alcohol, the composition of paraffin is removed, and the silicone membrane with a pore structure is obtained; eletrospinning is conducted on the silicone membrane to form a layer of biodegradable polymer nanofibers through an eletrospinning method, after drying is conducted, radiation sterilization is conducted, and a finished product is obtained.The wound dressing prepared through the method has good moisture retention and air permeability, the wound can be kept moist, hypertrophic scars are prevented, body tissue generation can be promoted by means of the unique support function of the nanofiber layer, and wound healing is accelerated.

Description

technical field [0001] The invention relates to the fields of biomedical engineering, medical equipment, biological materials and the like, in particular to a wound dressing and a preparation method thereof. Background technique [0002] Wound healing is a complex process, mainly including inflammatory phase, proliferative phase and repair phase. Wound treatment generally requires dressings to accelerate hemostasis, protect the wound surface, prevent bacterial infection, etc. to create a suitable wound healing environment. In 1963, Winter proposed the theory of moist wound healing. Cindinal et al. proved through experiments that a moist environment is more conducive to wound healing, because a moist environment is more suitable for cell growth. Traditional dressings such as gauze and bandages have large voids and high permeability, which makes the wound surface more prone to dehydration and does not have the function of moisturizing. Contents of the invention [0003] Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00
CPCA61F13/00A61L15/00A61F13/00046A61F13/00029A61F13/00987A61F2013/00463
Inventor 万华印张俊辉何婷李伟达朱晋辉
Owner GUANGZHOU DIANFANG BIOTECH CO LTD
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