Composition for preventing and treating hypertrophic scars, and drug and application thereof

A technology for hypertrophic scars and compositions, which is applied in the direction of drug combination, aerosol delivery, non-living material medical raw materials, etc., and can solve the problem of not being able to treat large-area hypertrophic scars, poor long-term curative effect, and poor curative effect, etc. problem, achieve the effect of fine and uniform medicine, relieve itching of the affected area, and good curative effect

Inactive Publication Date: 2015-09-30
CHANGSHA DARUIQI IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, simple surgical treatment of keloids has a very high postoperative recurrence rate; injection of hormones and radiotherapy have side effects of varying degrees, and cannot be used to treat large areas of hypertrophic scars; wearing elastic bandages or elastic sleeves for compression therapy, due to some Parts such as the perineum and face are difficult to achieve the required pressure and the curative effect is not good; some external drugs for inhibiting scar hyperplasia have disadvantages such as cumbersome use, slow effect, and poor long-term curative effect; curative effect

Method used

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  • Composition for preventing and treating hypertrophic scars, and drug and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The raw materials are 230 parts of medical grade dimethicone, 120 parts of glycerin, 50 parts of medical grade white oil, and 10 parts of cetostearyl alcohol (the mass ratio of hexadecyl alcohol and octastearyl alcohol is 3:7) , 20 parts of Tween 80, 10 parts of stearic acid, 5 parts of carbomer and 555 parts of water.

[0046] The preparation method of the composition for preventing and treating hypertrophic scars is:

[0047] Silicone oil, white oil, cetostearyl alcohol and stearic acid are mixed uniformly at 75°C, and then Tween 80 is slowly added and mixed uniformly to obtain the first mixture.

[0048] The carbomer is added to water to absorb water and expand, heated to 75° C. and mixed uniformly. After adding glycerin and mixing uniformly, the pH value is adjusted to 7.0 with a 1 mol / L triethanolamine aqueous solution to obtain a second mixture.

[0049] The first mixture and the second mixture are mixed, heated to 75°C and mixed uniformly to obtain.

Embodiment 2

[0051] The raw materials are 215 parts of medical grade simethicone, 140 parts of glycerin, 60 parts of medical grade white oil, 8 parts of cetostearyl alcohol (the mass ratio of hexadecyl alcohol and octastearyl alcohol is 7:3) , 22 parts of Tween 80, 8 parts of stearic acid, 7 parts of carbomer and 540 parts of water.

Embodiment 3

[0053] The raw materials are 250 parts of medical grade simethicone, 100 parts of glycerin, 40 parts of cosmetic grade white oil, 15 parts of cetostearyl alcohol (the mass ratio of hexadecyl alcohol and octastearyl alcohol is 5:5) , 25 parts of Tween 80, 9 parts of stearic acid, 1 part of carbomer and 560 parts of water.

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Abstract

The invention discloses a composition for preventing and treating hypertrophic scars, and a drug and application thereof. The composition comprises the following components in parts by weight: 200-250 parts of silicone oil, 100-150 parts of glycerinum, 40-80 parts of white oil, 2-15 parts of cetostearyl alcohol, 10-25 parts of tween 80, 2-15 parts of stearic acid, and 1-10 parts of carbomer. The composition for preventing and treating hypertrophic scars disclosed by the invention is simple to prepare, low in cost, free from preservative, steady in physicochemical property, exquisite, uniform and long in expiration date; when being used, the composition is directly coated on a wound; therefore, the composition is convenient and practical; pruritus at an affected part in the treatment process can be obviously lightened; therefore, the original colour of skin can be restored; chromatosis is avoided; obvious scars do not exist; formation of hypertrophic scars after operations, burns, scalds and trauma can be effectively prevented; and the composition has good curative effect on formed hypertrophic scars.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a composition for preventing and treating hypertrophic scars, and its medicament and application. Background technique [0002] Hypertrophic scars are traces of wound healing. The appearance is prominent, irregular in appearance, uneven, flushing and congestion, solid and tough, with burning pain and itching. [0003] The current methods of treating scars mainly include surgical treatment, local hormone injection, local radiotherapy, wearing elastic bandages or elastic sleeves, external application of drugs, and external scar sticking. However, surgical treatment of keloid scars has a very high postoperative recurrence rate; hormone injections and radiotherapy have side effects of varying degrees, and cannot be used to treat large-area hypertrophic scars; compression therapy with elastic bandages or elastic sleeves, because of some Parts such as the perineum and face are difficu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/06A61K9/06A61P17/02
Inventor 周天行
Owner CHANGSHA DARUIQI IND
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