The invention discloses a whitening and spot-removing facial mask containing coenzyme Q10, and a preparation method of the whitening and spot-removing facial mask. The whitening and spot-removing facial mask containing coenzyme Q10 comprises the following ingredients: disodium EDTA, allantoin, panthenol, bis-PEG-18 methyl ether dimethyl silane, a thickener, sodium hyaluronate, sodium polyglutamate, a polyol, acetyl chitin, hydroxyethylpiperazine ethane sulfonic acid, alpha-arbutin, beta-dextran, glycerin polyether-26, a PEG/PPG-17/6 copolymer, carboxymethyl chitosan, biosaccharide gum-1, hydroxylated lecithin, hydroxyethyl urea, a nano whitening and spot-removing agent, a nano coenzyme Q10 emulsion, an anti-sensitive soothing agent, an antiseptic and antibacterial agent, and purified water. The whitening and spot-removing facial mask containing coenzyme Q10 has excellent stability and skin compatibility, has obvious whitening and spot-removing effects, is mild to the skin, and has broad application prospects.