The invention belongs to the technical field of
biological materials, and particularly relates to a multifunctional beauty microneedle for improving
skin photoaging and a preparation method and application thereof. According to the invention, water-soluble
hyaluronic acid and
chitosan / beta-
sodium glycerophosphate temperature-sensitive hydrogel are used as a
polymer of a microneedle substrate layer, and the
polymer comprises
exosome of human adipose-derived mesenchymal stem cells and
epigallocatechin gallate. When the microneedle is inserted into the
skin,
hyaluronic acid is quickly dissolved after contacting with
tissue fluid, the needle tip is implanted into the
skin, and the CS / beta-GP temperature-sensitive hydrogel is in a
solid-gel-like state and can slowly release two cosmetic active ingredients in a long-acting manner under the influence of environment temperature and
humidity; the
facial mask has the effects of promoting tissue regeneration, reducing
hyperpigmentation, replenishing water, preserving
moisture, resisting oxidation, delaying
skin aging and the like, so as to achieve the medical beauty effects of reducing wrinkles, whitening, preserving
moisture, rejuvenating the face and the like. The microneedle provided by the invention can be further prepared into a patch, and is beneficial to treatment of wrinkles and stains at specific parts.