Novel skin repairing agent based on sponge microneedle and PDRN as well as preparation and application of novel skin repairing agent

Abstract

The invention discloses a novel skin repairing agent based on a sponge microneedle and PDRN and preparation and application thereof.The novel skin repairing agent comprises the sponge microneedle, the PDRN, hyaluronic acid, collagen, vitamin C. The novel skin repairing agent can be injected into the skin through the sponge microneedle and can repair skin damage, improve skin texture and promote skin cell regeneration, and the skin repairing effect is good. The anti-aging and beautifying effects are achieved. Meanwhile, the skin repairing agent can penetrate into the skin for repairing, the absorption capacity of the skin is improved, and the treatment effect is enhanced. The skin repairing agent disclosed by the invention has multiple beneficial effects, can effectively improve the skin quality and improve the skin health degree, and meets the requirements of people on beauty and health.

Description

Technical Field

[0001] The present invention relates to the field of medical cosmetology technology, and more specifically to a novel skin repair agent based on sponge microneedles and PDRN, and the preparation and application thereof. Background Art

[0002] The skin is one of the largest organs in the human body, and its functions include protection, perception, temperature regulation, metabolism, etc. However, due to factors such as age, ultraviolet radiation, environmental pollution, etc., the skin will have various problems, such as wrinkles, pigmentation, sagging, dryness, etc. These problems affect people's appearance and mental health, so the demand for skin repair and beauty is increasing.

[0003] At present, the skin repair agents on the market mainly include laser, photorejuvenation, microneedle, hyaluronic acid, botulinum toxin, etc. Among them, microneedle is a very popular skin repair method. Its principle is to create tiny channels on the skin surface through microneedles to break the skin barrier, so that the skin can absorb nutrients more easily. Microneedle can effectively improve skin texture, reduce wrinkles, improve pigmentation and other problems.

[0004] However, there are some disadvantages of traditional microneedle technology. First, traditional microneedles are usually needle-shaped, which can easily puncture the skin and cause pain and bleeding. Second, traditional microneedles can only operate on the surface of the skin and cannot penetrate deep into the skin, affecting its therapeutic effect. In addition, traditional microneedles can only inject some nutrients into the surface layer of the skin and cannot achieve a deeper repair effect.

[0005] Therefore, a new type of skin repair agent is needed that can penetrate deep into the skin for repair without piercing the skin, while also improving the skin's absorption capacity and enhancing the therapeutic effect. Summary of the invention

[0006] In view of this, the present invention provides a novel skin repair agent based on sponge microneedles and PDRN, and a preparation and application method thereof.

[0007] To achieve the above object, the present invention provides the following technical solutions, which mainly include:

[0008] A new skin repair agent based on sponge microneedles and PDRN, mainly including sponge microneedles, and a mixture of PDRN, hyaluronic acid, collagen and vitamin C.

[0009] Preferably, in the above-mentioned novel skin repair agent based on sponge microneedles and PDRN, the length of the sponge microneedles is 0.5 mm to 2.0 mm, and the diameter is 0.1 mm to 0.3 mm.

[0010] Preferably, in the novel skin repair agent based on sponge microneedles and PDRN, the concentration of PDRN is 0.1 mg / ml to 10 mg / ml.

[0011] Preferably, in the above-mentioned novel skin repair agent based on sponge microneedles and PDRN, the concentration of hyaluronic acid is 0.1 mg / ml to 10 mg / ml, the concentration of collagen is 0.1 mg / ml to 10 mg / ml, and the concentration of vitamin C is 0.1 mg / ml to 10 mg / ml.

[0012] A method for preparing a novel skin repair agent based on sponge microneedles and PDRN comprises the following steps:

[0013] Step 1: Prepare the required materials, including sponge microneedles, PDRN, hyaluronic acid, collagen and vitamin C;

[0014] Step 2: Add hyaluronic acid, collagen and vitamin C into the syringe and mix well;

[0015] Step 3: Dissolve PDRN in saline at a concentration of 0.1 mg / ml to 10 mg / ml;

[0016] Step 4: Evenly mix the solutions in step 2 and step 3 to obtain a mixed solution containing hyaluronic acid, collagen, vitamin C and PDRN;

[0017] Step 5: Soak the sponge microneedle in the mixed solution to allow it to fully absorb the mixed solution;

[0018] Step 6: Take out the soaked sponge microneedles and remove the excess mixed solution to obtain a skin repair agent containing sponge microneedles, PDRN, hyaluronic acid, collagen and vitamin C;

[0019] Step 7: Pour the prepared skin repair agent into a syringe and sterilize it before use.

[0020] Preferably, in the above-mentioned method for preparing the novel skin repair agent based on sponge microneedles and PDRN, 10-30 parts of PDRN, 20-50 parts of hyaluronic acid, 10-40 parts of collagen, and 20-30 parts of vitamin C are mixed to form a mixed solution.

[0021] An application of a new skin repair agent based on sponge microneedles and PDRN, which can be used for skin repair, forming tiny channels on the skin surface to promote the absorption and regeneration of skin tissue.

[0022] It can be known from the above technical scheme that compared with the prior art, the present invention discloses a novel skin repair agent based on sponge microneedles and PDRN and its preparation and application. The present invention can effectively repair skin damage and promote skin cell regeneration by injecting sponge microneedles into the skin. The present invention contains ingredients such as hyaluronic acid and collagen, which can increase the moisture retention, elasticity and brightness of the skin, improve the glossiness and health of the skin, and also contains antioxidant ingredients such as vitamin C in the present invention, which can resist the invasion of free radicals and reduce the phenomenon of skin aging. The present invention can improve skin texture, reduce wrinkles, improve pigmentation and other problems, and achieve beauty effects. The present invention can also be used in combination with other beauty treatment methods, such as photorejuvenation, laser spot removal, etc., to enhance the therapeutic effect.

[0023] In summary, the skin repair agent of the present invention has multiple beneficial effects, can effectively improve skin quality, improve skin health, meet people's needs for beauty and health, and has broad application prospects. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] The present invention mainly includes the following embodiments

[0026] Embodiment 1:

[0027] Prepare materials: sponge microneedles made of medical polyvinyl alcohol, PDRN, hyaluronic acid, collagen, and vitamin C. The length of the sponge microneedle is 0.5 mm, the diameter is 0.1 mm, the concentration of PDRN is 0.1 mg / ml, the concentration of hyaluronic acid is 0.1 mg / ml, the concentration of collagen is 0.1 mg / ml, and the concentration of vitamin C is 0.1 mg / ml. Take 10 parts of PDRN, 20 parts of hyaluronic acid, 10 parts of collagen, and 20 parts of vitamin C and mix them to make a mixed solution.

[0028] Soak the sponge microneedles in a solution containing PDRN, hyaluronic acid, collagen, and vitamin C to fully absorb the nutrients. Stick the sponge microneedles on the skin according to the required number and density, and press gently to make them fully contact with the skin. Inject the sponge microneedles into the skin to release the nutrients into the skin. Wait for a certain period of time to allow the skin to fully absorb the nutrients. Wash the skin and complete the treatment.

[0029] Embodiment 2:

[0030] Prepare materials: sponge microneedles made of medical polyvinyl alcohol, PDRN, hyaluronic acid, collagen, and vitamin C. The length of the sponge microneedle is 2.0 mm, the diameter is 0.3 mm, the concentration of PDRN is 10 mg / ml, the concentration of hyaluronic acid is 10 mg / ml, the concentration of collagen is 10 mg / ml, and the concentration of vitamin C is 10 mg / ml. Take 30 parts of PDRN, 50 parts of hyaluronic acid, 40 parts of collagen, and 30 parts of vitamin C and mix them to make a mixed solution.

[0031] Soak the sponge microneedles in a solution containing PDRN, hyaluronic acid, collagen, and vitamin C to fully absorb the nutrients. Stick the sponge microneedles on the skin according to the required number and density, and press gently to make them fully contact with the skin. Inject the sponge microneedles into the skin to release the nutrients into the skin. Wait for a certain period of time to allow the skin to fully absorb the nutrients. Wash the skin and complete the treatment.

[0032] Embodiment three:

[0033] Prepare materials: sponge microneedles made of medical polyvinyl alcohol, PDRN, hyaluronic acid, collagen, and vitamin C. The length of the sponge microneedle is 1.5 mm, the diameter is 0.2 mm, the concentration of PDRN is 0.1 mg / ml, the concentration of hyaluronic acid is 5 mg / ml, the concentration of collagen is 3 mg / ml, and the concentration of vitamin C is 1 mg / ml. Take 20 parts of PDRN, 40 parts of hyaluronic acid, 30 parts of collagen, and 15 parts of vitamin C and mix them to make a mixed solution.

[0034] Soak the sponge microneedles in a solution containing PDRN, hyaluronic acid, collagen, and vitamin C to fully absorb the nutrients. Stick the sponge microneedles on the skin according to the required number and density, and press gently to make them fully contact with the skin. Inject the sponge microneedles into the skin to release the nutrients into the skin. Wait for a certain period of time to allow the skin to fully absorb the nutrients. Wash the skin and complete the treatment.

[0035] Embodiment 4:

[0036] Prepare materials: sponge microneedles made of medical polyvinyl alcohol, PDRN, hyaluronic acid, collagen, and vitamin C. The length of the sponge microneedle is 0.8 mm, the diameter is 0.25 mm, the concentration of PDRN is 3 mg / ml, the concentration of hyaluronic acid is 5 mg / ml, the concentration of collagen is 8 mg / ml, and the concentration of vitamin C is 7 mg / ml. Take 18 parts of PDRN, 40 parts of hyaluronic acid, 15 parts of collagen, and 15 parts of vitamin C and mix them to make a mixed solution.

[0037] Soak the sponge microneedles in a solution containing PDRN, hyaluronic acid, collagen, and vitamin C to fully absorb the nutrients. Stick the sponge microneedles on the skin according to the required number and density, and press gently to make them fully contact with the skin. Inject the sponge microneedles into the skin to release the nutrients into the skin. Wait for a certain period of time to allow the skin to fully absorb the nutrients. Wash the skin and complete the treatment.

[0038] Embodiment five:

[0039] Prepare materials: sponge microneedles made of medical polyvinyl alcohol, PDRN, hyaluronic acid, collagen, and vitamin C. The length of the sponge microneedle is 1.8 mm, the diameter is 0.1 mm, the concentration of PDRN is 0.1 mg / ml, the concentration of hyaluronic acid is 5 mg / ml, the concentration of collagen is 7 mg / ml, and the concentration of vitamin C is 6 mg / ml. Take 15 parts of PDRN, 20 parts of hyaluronic acid, 10 parts of collagen, and 30 parts of vitamin C and mix them to make a mixed solution.

[0040] Soak the sponge microneedles in a solution containing PDRN, hyaluronic acid, collagen, and vitamin C to fully absorb the nutrients. Stick the sponge microneedles on the skin according to the required number and density, and press gently to make them fully contact with the skin. Inject the sponge microneedles into the skin to release the nutrients into the skin. Wait for a certain period of time to allow the skin to fully absorb the nutrients. Wash the skin and complete the treatment.

[0041] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0042] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A novel skin repair agent based on sponge microneedles and PDRN, characterized in that: It mainly includes sponge microneedles, and a mixture of PDRN, hyaluronic acid, collagen and vitamin C.

2. The novel skin repair agent based on sponge microneedles and PDRN according to claim 1, characterized in that, The sponge microneedle has a length of 0.5 mm to 2.0 mm and a diameter of 0.1 mm to 0.3 mm.

3. The novel skin repair agent based on sponge microneedles and PDRN according to claim 1, characterized in that, The concentration of the PDRN is 0.1 mg / ml to 10 mg / ml.

4. The novel skin repair agent based on sponge microneedles and PDRN according to claim 1, characterized in that, The concentration of the hyaluronic acid is 0.1 mg / ml to 10 mg / ml, the concentration of the collagen is 0.1 mg / ml to 10 mg / ml, and the concentration of the vitamin C is 0.1 mg / ml to 10 mg / ml.

5. A method for preparing a novel skin repair agent based on sponge microneedles and PDRN, characterized in that: The following steps are involved: Step 1: Prepare the required materials, including sponge microneedles, PDRN, hyaluronic acid, collagen and vitamin C; Step 2: Add hyaluronic acid, collagen and vitamin C into the syringe and mix well; Step 3: Dissolve PDRN in saline at a concentration of 0.1 mg / ml to 10 mg / ml; Step 4: Evenly mix the solutions in step 2 and step 3 to obtain a mixed solution containing hyaluronic acid, collagen, vitamin C and PDRN; Step 5: Soak the sponge microneedle in the mixed solution to allow it to fully absorb the mixed solution; Step 6: Take out the soaked sponge microneedles and remove the excess mixed solution to obtain a skin repair agent containing sponge microneedles, PDRN, hyaluronic acid, collagen and vitamin C; Step 7: Pour the prepared skin repair agent into a syringe and sterilize it before use.

6. The preparation method of the novel skin repair agent based on sponge microneedles and PDRN according to claim 5, characterized in that, 10-30 parts of the PDRN, 20-50 parts of the hyaluronic acid, 10-40 parts of the collagen, and 20-30 parts of the vitamin C are mixed to prepare a mixed solution.

7. Application of a novel skin repair agent based on sponge microneedles and PDRN, characterized in that: This repair agent can be applied to skin repair, forming tiny channels on the skin surface to promote the absorption and regeneration of skin tissue.