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Prescription and preparation method for tranilast gel and ointment

A special gel and ointment technology applied in the field of medical science and technology to achieve full absorption, avoid liver and kidney toxicity, and reduce the risk of systemic adverse reactions

Inactive Publication Date: 2015-07-22
药大制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In response to the above problems, the present invention has prepared a gel dosage form and a cream dosage form containing tranilast components, which solves the problem of using tranilast in vitro

Method used

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  • Prescription and preparation method for tranilast gel and ointment
  • Prescription and preparation method for tranilast gel and ointment
  • Prescription and preparation method for tranilast gel and ointment

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Embodiment Construction

[0018] The present invention will be described in further detail below in conjunction with specific examples.

[0019]

[0020] Preparation:

[0021] 1. Take the prescribed amount of carbomer, add an appropriate amount of purified water, fully swell at 20-80°C, adjust the pH to below 5, add the prescribed amount of glycerin, and keep warm to get A.

[0022] 2. Weigh the prescribed amount of tranilast, co-solvent, methyl p-hydroxybenzoate, and an appropriate amount of purified water, heat to dissolve at 20-80°C, and keep warm to obtain B.

[0023] 3. Pour B into A, keep warm and swell, and stir well.

[0024]

[0025] Preparation:

[0026] 1. Take the prescribed amount of hydroxypropyl methylcellulose, add an appropriate amount of purified water, fully swell at 20-80°C, adjust the pH to below 5, add the prescribed amount of glycerin, and keep warm to obtain A.

[0027] 2. Weigh the prescribed amount of tranilast, co-solvent, methyl p-hydroxybenzoate, and an appropria...

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Abstract

Belonging to the field of medical technologies, the invention relates to a prescription and preparation method for topical gel and ointment dosage forms containing tranilast component, and therapeutic effects of the dosage forms in keloid and hypertrophic scar fields. The topical gel and ointment contain tranilast, a cosolvent, a substrate, a humectant, a penetration enhancer, a preservative, a pH regulator, purified water and other ingredients. The preparation method includes the steps of: 1. taking a prescribed amount of the substrate, adding a proper amount of purified water, performing full swelling at 20-80DEG C, adjusting the pH to less than 5, adding a prescribed amount of humectant, and conducting heat preservation to obtain A; 2. taking a prescribed amount of tranilast, the cosolvent, the preservative, and a proper amount of purified water, carrying out heating dissolving at 20-80DEG C, and performing heat preservation to obtain B; and 3. Pouring B into A, conducting heat preservation and swelling, and stirring the mixture evenly, thus obtaining the products. The tranilast gel and ointment provided by the invention have the pharmacological activity of treating hypertrophic scars and keloids.

Description

technical field [0001] The invention relates to the prescription and preparation method of an external gel and ointment containing tranilast components, and its therapeutic effect in the field of keloid and hypertrophic scar, belonging to the field of medical science and technology. Background technique [0002] Tranilast was first used as an allergic mediator blocker, which inhibits the degranulation of mast cells and the release of allergic mediators caused by allergens and other stimuli. It has the function of stabilizing the cell membrane of mast cells and basophils, preventing their degranulation. Thereby inhibiting the release of histamine and 5-hydroxytryptamine allergic reaction substances, and has a significant inhibitory effect on the skin allergic reaction and experimental asthma caused by IgE antibodies, and is an etiological and therapeutic drug aimed at the occurrence mechanism of allergic diseases. [0003] In the 1990s, it was discovered that tranilast has a...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/167A61P17/02A61P17/00
Inventor 郝静梅尹莉芳傅继华赵馨
Owner 药大制药有限公司
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