Liposome gel preparation and preparation method and application thereof

Abstract

The invention provides a liposome gel preparation for treating hypertrophic scars. The liposome gel preparation comprises liposome, gel material and glycerol, wherein the liposome is encapsulated with paeonol, and the surface of the liposome is bonded with vascular endothelial growth factor (VEGF) antibodies through polyethylene glycol. The invention provides a preparation method and application of the gel preparation at the same time. The gel preparation is encapsulated by using a material such as phospholipid with good physiological compatibility with the human body, so that the problems of poor water solubility and low stability of the paeonol are effectively solved. The VEGF antibodies are used for modifying the surface of the liposome, lipid particles enter the dermis through the epidermis by using the permeation promoting effect of liposome carriers and are directionally bonded with VEGF receptors of the pathological change skin part, and the encapsulated medicament is released at the same time, so that positioned retention of the medicament in the scar hyperplasia part is realized. Compared with other reported scar hyperplasia resistant medicament preparations or treatment schemes, the invention has the advantages that the liposome gel preparation is low in relapse rate, reduces the occurrence rate of the toxic or side effect and can be applied to any scar hyperplasia part of the body.

Description

technical field

[0001] The invention mainly relates to a liposome gel preparation, in particular to a paeonol immune liposome gel preparation. The invention also relates to the preparation method and application of the gel preparation. Background technique

[0002] Hypertrophic scars (Hypertrophic scars, HS) is a progressive, pathological and irreversible skin disease, often occurs in the repair process of deep trauma (such as surgery, burns and scalds), caused by a large number of micro-vascularization, fibroblast proliferation , Excessive deposition of collagen leads to excessive fibrosis of the dermis. Medical research results have shown that the degree of scar hyperplasia is positively correlated with the density of microvessels in the wounded skin, in which vascular endothelial growth factor (vascular endothelial growth factor, VEGF) plays a key role in physiological and pathological angiogenesis. After tissue trauma, factors such as inflammation, allergic reaction, h...

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