A kind of cryptotanshinone skin keratin liposome preparation and its preparation method
A technology of cryptotanshinone and keratin, which is applied in the field of pharmaceutical preparations, can solve the problems of inducing liver drug enzymes, easy decomposition when exposed to light, and poor water solubility, and achieve the effects of improving local bioavailability, improving poor water solubility, and reducing side effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0022] The present invention is a preparation method of cryptotanshinone skin keratinoid body. Calculated by weight, the formula includes the following components: 0.5-7 parts of cryptotanshinone, 30-100 parts of ceramide, 20-125 parts of lecithin, and 10 parts of cholesterol. ~200 parts, organic phase 800-5000 parts, aqueous phase 2000-12500 parts. In the formula, cryptotanshinone is the main drug; lecithin and ceramide are used as film-forming materials, and the lecithin is preferably one or two mixtures of soybean lecithin, hydrogenated lecithin, and egg yolk lecithin; cholesterol is a membrane stabilizer, regulating The fluidity of the membrane; the organic phase is selected from absolute ethanol or diethyl ether; the ceramide is a water-soluble ceramide; the water phase can be selected from phosphate buffered saline solution or distilled water with different pH values according to the properties of the drug.
[0023] The present invention mainly adopts an organic solven...
Embodiment 1
[0026] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of a phosphate buffered saline solution with pH 7.4 to obtain an aqueous phase, and place it in a magnetic Preheat to 50°C on the stirrer; keep the temperature, keep the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, continue stirring for 3h to volatilize the ethanol, and transfer to a brown glass bottle for storage.
Embodiment 2
[0028] Dissolve 1.5 mg of cryptotanshinone, 0.1 g of soybean lecithin, and 0.025 g of cholesterol in 3 mL of absolute ethanol to obtain an organic phase; dissolve 0.03 g of ceramide in 10 mL of a phosphate buffered saline solution with pH 7.4 to obtain an aqueous phase, and place it in a magnetic Preheat to 50°C on the stirrer; keep the temperature, keep the magnetic stirring speed at 600rpm, slowly drop the organic phase into the water phase with a syringe, continue stirring for 3h to volatilize the ethanol, and transfer to a brown glass bottle for storage.
PUM
Property | Measurement | Unit |
---|---|---|
particle size | aaaaa | aaaaa |
refractive index | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com