Capsaicin injection for treating osteoarthritis and preparation method of capsaicin injection

Abstract

The invention discloses a capsaicin injection for treating osteoarthritis and a preparation method thereof. The injection is composed of capsaicin, an organic solvent, a pH regulator and water, wherein the content of the organic solvent is 40%-80% (w / w). The capsaicin injection provided by the invention is simple in preparation mode, small in toxic or side effect, rapid in curative effect and long-acting.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a capsaicin injection for treating osteoarthritis and a preparation method thereof. Background technique [0002] OA (Osteoarthritis) is a degenerative disease, which is caused by many factors such as aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and other factors. Hyperplasia, also known as osteoarthritis, degenerative arthritis, senile arthritis, hypertrophic arthritis, etc. Clinical manifestations include slowly developing joint pain, tenderness, stiffness, joint swelling, limited mobility, and joint deformity. Is the eighth most common disorder among subjects 65-74 years of age who seek treatment from a primary care physician, and for subjects over 75 years of age it is the third most common disorder (Mamlin et al., 1998; 2003) . US DHHS, 1992). Osteoarthritis of the knee is characterized by chronic pain, degradation of the ...

AI Technical Summary

Problems solved by technology

However, NSAIDS have side effects of gastrointestinal mucosal damage, and should be used with caution in patients with peptic ulcers.

[0004] (2) Glucocorticoids: often used by local injection, it can improve inflammation and relieve pain obviously, but the use should be limited, repeated use will cause damage to the joints

[0011] Although the existing capsaicin patch has the effect of analgesia and anti-inflammation, its skin irritation problem (burning sensation and tingling sensation are produced at the medication site) needs urgently. Improvement, can only be used on intact skin, not on damaged skin

[0012]At present, there is no clear and targeted quick-acting and long-acting drug for the treatment of OA. The treatment of OA is limited to short-term use and cannot achieve long-term effect. This product can Provide new ideas for OA treatment

[0013] patent document CN201780075307.X discloses a stable aqueous capsaicin injectable preparation and its medical application, which uses long-chain fatty acid polyethylene glycol ester as Solubilizing agent, in order to ensure the dissolution state of the solubilizing agent requires a lower pH, the prepared preparation is irritating in clinical application due to the low pH, the literature points out that the injection needs to be used in combination with an anesthetic, it cannot be used alone, and it will last for a long time. The safety of chain fatty acid polyethylene glycol esters in water injection application needs to be confirmed

[0014] patent document CN200380109828.0 discloses a method of relieving the human or animal by administering capsaicinoids to a certain part of the human or animal in need thereof. Compositions and methods for pain, the document provides the idea of ​​capsaicin preparations for the treatment of pain, the basic prescription consists of capsaicin and a carrier, which can be prepared into different dosage forms for different routes of administration for different indications, but the document No specific technical content was elaborated

Images