23 results about "Capsazepine" patented technology

The invention relates to the technical field of power cables, and discloses a manufacturing process of a flame-retardant anti-rat-bite cable, which comprises the following steps: step S1, mixing and granulating in an inert atmosphere; step S2, conductor pretreatment; step S3, carrying out multi-layer co-extrusion coating; s4, gradient cooling and interface strengthening are carried out, and the co-extruded cable passes through a three-section type cooling tank in sequence to be cooled; and after cooling, carrying out electron beam irradiation crosslinking treatment on the cable immediately. The cable comprises a flame-retardant sheath layer, a long-acting rat-bite-proof layer, an insulating layer and a conductor from outside to inside. According to the invention, capsaicin is coated in a gelatin-Arabic gum composite capsule wall through a microencapsulation technology to form a physical isolation barrier, and the structure effectively prevents the contact between the repellent and the external environment, so that even in high-temperature mixing and long-term use, volatile components can be prevented from escaping, and the slow release period of the effective components is ensured to cover the design life of the cable.

The invention discloses application of capsaicin to resistance of grass carp to hypoxia stress, and belongs to the technical field of agricultural cultivation. Aiming at the problems of red blood cell function damage, liver and gill tissue damage and the like of grass carps under hypoxia stress, a trace amount of capsaicin is added into the grass carp feed, so that the feed formula is optimized, the reduction of red blood cell quantity and brittleness increase of grass carps in the later growth period caused by hypoxia stress are relieved, liver damage is relieved, and the growth period of grass carps is prolonged. The death rate of the grass carp in a low-oxygen environment is reduced, the culture risk is reduced, and the method has the characteristics of being green, safe, low in cost and remarkable in economic benefit and is suitable for large-scale grass carp culture industry.

The invention discloses a lacrimation composition and a preparation method of the lacrimation composition, and the lacrimation composition comprises the following raw materials in parts by weight: 0.5-1.5 parts of capsaicin; 5 to 10 parts of capsicum oleoresin; 80 to 90 parts of a preservative; 0.1 to 0.2 part of a thickening agent; and 1 to 1.3 parts of absolute ethyl alcohol. By adding more preservatives and a proper amount of thickeners into the lacrimation composition, the long-term storage stability and reliability of the lacrimation composition can be improved, and then the storage life of the lacrimation composition is prolonged.

The invention discloses a colorless capsicum oleoresin microemulsion and a preparation method and application thereof, and belongs to the technical field of food processing.The preparation method of the colorless capsicum oleoresin microemulsion comprises the following steps that oil-soluble capsicum oleoresin and an emulsifier are heated, then water is added for mixing, and water-soluble capsicum oleoresin is obtained; adding an enzyme preparation into the water-soluble capsicum oleoresin, and carrying out ultrasonic enzymolysis reaction to obtain an enzymolysis solution; and carrying out enzyme inactivation treatment on the enzymolysis solution, and then centrifuging to remove precipitate to obtain supernate, namely the colorless capsicum oleoresin microemulsion. According to the method, colored capsanthin is degraded into colorless substances through mild enzymolysis reaction, and meanwhile, capsaicin molecules are prevented from being damaged. The colorless capsicum oleoresin microemulsion prepared by the invention has the advantages of high stability, improved fluidity and few impurities, and is beneficial to application in colorless or light-colored food.

The present disclosure relates generally to derivatives of capsazepine and methods of use thereof. In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases.

The invention discloses a method for synthesizing dihydrocapsaicin, and the method comprises the following steps: synthesizing a first intermediate 1-isobutylcyclohexene, a second intermediate 8-methyl-6-oxonanoic acid, a third intermediate 8-methylnonanoic acid and a target product dihydrocapsaicin. The method uses cyclohexanone, isobutylmagnesium bromide and vanillin ammonium hydrochloride as raw materials, and obtains the product dihydrocapsaicin by stepwise reaction. Each reaction step adopts a conventional chemical reaction, and the reaction conditions are mild. The feasibility of the synthesis process is high, the safety and environmental protection are strong, and the product has a high yield and good purity, and is suitable for industrial production.

The invention relates to a nano-composite for promoting thermalization of cold tumors as well as a preparation method and application of the nano-composite. The nano-composite comprises capsaicin and graphene oxide. According to the invention, capsaicin is combined with graphene oxide, so that immunogenic cell death and active oxygen mediated pyroptosis can be promoted, and infiltration and activation of CD4 < + > and CD8 < + > T cells can be remarkably enhanced by the combined immunoreaction, so that potent anti-tumor immunoreaction is induced, and remarkable tumor inhibition is realized.

This invention discloses a method for preparing capsaicin-like substances by temperature-responsive eutectic solvent extraction, comprising the following steps: drying Yunnan chili peppers (after removing stems and seeds), pulverizing, sieving, and collecting the chili powder; mixing lidocaine (HBA) with six alkane-chain carboxylic acids (valerate, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, and lauric acid) at a 1:1 molar ratio to form a homogeneous and transparent liquid, TRDES; weighing the chili powder, adding it to the TRDES aqueous solution, and extracting by shaking; after extraction, centrifuging, and diluting the supernatant to obtain capsaicin-like substances. This invention uses temperature-responsive eutectic solvent extraction to prepare capsaicin-like substances, which is simple, highly efficient, and allows for the recycling of extraction reagents, effectively saving resources. It has significant practical and industrial value for promoting the large-scale production of capsaicin-like substances and enhancing their high-value applications.

The application provides a preparation method of natural capsaicin, comprising the following steps: a) mixing oil-soluble oleoresin capsicum with polysorbate dispersant to obtain a mixed solution; b) mixing and dissolving the mixed solution with lye, and then performing dilution treatment to obtain a diluted solution; and c) adjusting the pH value of the diluted solution, and then performing crystallization to obtain capsaicin. The application also provides natural capsaicin. In the application, polysorbate compound is used as a dispersant, mixed with oil-soluble oleoresin capsicum, dissolved with lye, diluted, and then crystallized after adjusting the pH value to obtain natural capsaicin. The natural capsaicin obtained by the method provided by the application mainly comprises capsaicin, dihydrocapsaicin, nordihydrocapsaicin, vanillyl nitrile, capsaicin II and dihydrocapsaicin I, and has the advantages of clear components, high purity and high transfer rate.

The present invention discloses an anti-biofouling ultrafiltration membrane containing a natural antibacterial material derivative, and its preparation method and application. The preparation method of the anti-biofouling ultrafiltration membrane of the present invention is as follows: (1) synthesizing an antibacterial material capsaicin derivative and transforming the membrane matrix through atom transfer radical polymerization (ATRP); (2) combining the capsaicin derivative with the transformed membrane matrix through an esterification reaction to obtain an antibacterial polymer; (3) subjecting the above polymer to non-solvent induced phase separation (NIPS) to prepare an anti-biofouling ultrafiltration membrane. The process of the present invention is simple, easy to operate, and cost-controlled, and can achieve large-scale industrial production. The anti-biofouling ultrafiltration membrane prepared by the present invention uses a natural antibacterial material derivative. While ensuring safety and friendliness to the environment and humans, it exhibits excellent ability to resist the growth and proliferation of microorganisms on the membrane surface and has good application prospects in water treatment processes.

The invention belongs to the technical field of underwater acoustic equipment protection, and relates to an acoustic transmission protection material and underwater acoustic equipment protection equipment made of the acoustic transmission protection material, the acoustic transmission protection material is formed by mixing capsaicin and graphite and then pressing the mixture at high temperature and high pressure, the capsaicin accounts for 5%-10%, the temperature does not exceed 200 DEG C during pressing, and the graphite accounts for 5%-10% during pressing. The pressure is greater than 10 Mpa / cm < 2 >. Capsaicin in the sound transmission protection material can force marine organisms to be away from each other and avoid attachment, graphite has good sound transmission and conductivity, an electric field can be generated after electrification, most marine attachment organisms are sensitive to the electric field, can actively avoid a conductive area and then cannot be attached to the underwater acoustic equipment, and in addition, the sound transmission protection material can be applied to the underwater acoustic equipment. Graphite has better sound transmission performance and electrical conductivity, the structural stability is higher, and better corrosion resistance is achieved.

The invention discloses an application of capsaicin in improving fish meat quality, and belongs to the technical field of aquaculture. The improvement of the fish meat quality by capsaicin is realized by improving the meat yield, increasing the crude protein content, slowing down the pH decreasing amplitude, reducing the cooking loss, improving the hardness, improving the freshness, increasing the sweet taste and the salty taste, inhibiting the generation of methyl mercaptan and ethanethiol, promoting the synthesis of fresh flavor substances, increasing the contents of ATP, Ca < 2 + >-Mg < 2 + >-ATPase, creatine kinase, HK and glycogen and reducing the lactic acid content. By adding low-dose capsaicin into the fish feed for feeding fish, the flavor quality of aquatic products can be effectively improved, and technical support is provided for application of low-dose natural additives in the field of aquatic product preservation and aroma enhancement.

The invention discloses a medicament for treating diabetes and a preparation method thereof, and relates to the field of high polymer materials. When the medicament for treating diabetes is prepared, chitosan and thioglycollic acid react to prepare sulfydryl modified chitosan; reacting the sulfydryl modified chitosan with a mixed solution of zein and capsaicin to prepare capsaicin sustained-release microspheres; the preparation method comprises the following steps: reacting metformin hydrochloride, gelatin, hydroxyethyl cellulose and polyvinyl alcohol to prepare metformin hydrochloride microspheres; the capsaicin sustained-release microspheres, metformin hydrochloride microspheres, magnesium stearate, carboxymethyl starch sodium and adhesive particles are tableted to prepare tablets, and the tablets are coated with a coating solution to prepare the capsaicin sustained-release tablet. The medicament for treating diabetes mellitus prepared by the invention has good slow release performance and low irritation to stomach.

The invention discloses a silver ink film capable of detecting capsaicin with high sensitivity, a preparation method of the silver ink film and application of the silver ink film in surface enhanced Raman scattering detection. The preparation method comprises the following steps: adding a mixed solution of sodium hydroxide and hydroxylamine hydrochloride into a silver nitrate solution while stirring, and keeping stirring until the reaction is complete to obtain a uniform milky white mixture silver nano glue solution; centrifuging the silver nano glue solution for 5-30 minutes at the speed of 5000-15000 r / min, and discarding a supernatant liquid part to obtain concentrated silver nano glue; mixing and stirring the concentrated silver nano glue with ethyl cellulose and alpha-terpilenol, and performing ultrasonic treatment to obtain uniform silver ink; in the silver ink, the content of the concentrated silver nano glue is 25wt%-55wt%, the content of ethyl cellulose is 4wt%-6wt%, and the balance is alpha-terpilenol; and spin-coating the silver ink on a clean polished silicon wafer by using a spin coater, and carrying out vacuum drying to obtain the silver ink film.

The present application relates to the technical field of self-heating fabric, in particular to a sunscreen skin-protecting antibacterial self-heating warm-keeping fabric containing capsaicin and a preparation method thereof. The present application applies capsaicin to the field of textile fabric for the first time, opens up a wider application of capsaicin, and improves its economic benefits. The silica-coated capsaicin powder is prepared by sol-gel technology, and then added into the spinning dope to prepare the original yarn with antibacterial, ultraviolet-proof and far-infrared heating properties. Then, the fabric with antibacterial, ultraviolet-proof and far-infrared heating functions is prepared through weaving and dyeing and finishing processes.

The invention relates to a capsaicin and local anesthetic liquid eutectic and a composition thereof, and more specifically, the capsaicin and local anesthetic liquid eutectic comprises (a) capsaicin; (b) local anesthetics; (c) water; wherein the molar ratio of the component (a) capsaicin to the component (b) local anesthetic is (1: 0.5)-(1: 10), preferably (1: 0.6)-(1: 6), and more preferably (1: 0.75)-(1: 5); the component (c) accounts for at least 1%, preferably at least 3%, preferably at least 5% and more preferably at least 6% of the mass percent of the eutectic; the invention also discloses a pharmaceutical composition containing the eutectic, the eutectic is stable at room temperature, and the further prepared pharmaceutical composition is free of drug crystal precipitation after being placed for a long time, and is stable and controllable in quality.

The invention discloses an application of capsaicin in intestinal organ culture and a culture solution containing capsaicin, and belongs to the technical field of tissue culture. The intestinal organ culture solution comprises capsaicin with the concentration of 1.25-5 [mu] mol / L and a stem cell culture solution. When the culture solution is used in pig jejunum organ culture, generation and budding of jejunum crypt organs can be remarkably promoted, and cell growth and intestinal organ amplification are effectively promoted. According to the method for promoting amplification of the intestinal organs provided by the invention, many limitations of a traditional model can be overcome, and the development of intestinal pathology is assisted.

The invention relates to a high-concentration capsaicin composition, and more specifically, the composition comprises capsaicin and menthol, further comprises a high polymer material and an emulsifier, further comprises oil, and further comprises one or more of a thickening agent, a humectant, a preservative and an antioxidant. The composition does not need to use an organic solvent, contains high-concentration capsaicin, is free of drug crystal precipitation after being placed for a long time, is controllable in quality, and also has the beneficial effect that the transdermal rate is obviously higher than that of common cream.

The application provides a method for preparing fertilizer by treating capsaicin waste liquid with pig manure water and synergistic compound microbial agent, and is characterized by the following steps: 1) uniformly mixing capsaicin crystallization refined waste liquid and pig manure water according to the following mass percentage: 30-60% of capsaicin crystallization refined waste liquid, 40-70% of pig manure water, and adjusting the pH value of the mixed solution to 6.0-9.0; 2) adding potassium fulvate in an amount of greater than or equal to 0.5 kg per ton of the mixed solution, then adding compound biological enzyme in an amount of 0.5 kg per ton of the mixed solution, and stirring and activating for 30-40 minutes; 3) adding compound microbial agent in an amount of greater than or equal to 0.5 kg per ton of the mixed solution, and aerating for 45-50 hours under the conditions of a temperature of 20-30 DEG C and dissolved oxygen of 2-4 mg / L; and 4) directly preparing organic water-soluble fertilizer or soil improvement base agent. The capsaicin degradation rate is greater than or equal to 70%, the COD removal rate is greater than or equal to 65%, the ammonia nitrogen removal rate is greater than or equal to 80%, and the method is suitable for large-scale industrial application.

The application relates to the technical field of traditional Chinese medicine external preparation, and discloses a formula of a stomach-warming and abdomen-soothing plaster, which comprises 16 kinds of traditional Chinese medicine micro-powder such as Piper longum, Evodia rutaecarpa, Alpinia officinarum Hance, Corydalis tuber, Poria cocos, Aucklandia lappa Decne and Gekko japonicus. A hot melt adhesive matrix is composed of styrene-isoprene-styrene block copolymer, hydrogenated rosin glyceride and medical white oil. The preparation method involves traditional Chinese medicine ultra-micro grinding, matrix melting, and adding active ingredients under the condition of 100-110 DEG C for closed high-speed shearing homogenization, and finally coating and forming. The warm and hot effect generated by capsaicin stimulating microcirculation is synergized with the keratin layer lipid disturbance effect of azone, a warm and hot penetration carrier is constructed, and the transdermal speed of the medicine is improved. In combination with the modified hot melt adhesive matrix and the high-temperature homogenization process, the problems of heavy metal residues, easy flow and medicine aggregation of traditional plasters are solved, and the plaster has the characteristics of quick effect, strong adhesion and good biocompatibility.

The present invention discloses a silver ink film capable of highly sensitive detection of capsaicin, a preparation method thereof, and an application thereof in surface-enhanced Raman scattering detection. The preparation method comprises: adding a mixed solution of sodium hydroxide and hydroxylamine hydrochloride to a silver nitrate solution under stirring, and stirring until the reaction is complete to obtain a uniform milky white mixture of silver nanocolloid; centrifuging the silver nanocolloid at a speed of 5000-15000 r / min for 5-30 minutes, discarding the supernatant to obtain concentrated silver nanocolloid; mixing the concentrated silver nanocolloid with ethyl cellulose and α-terpineol, stirring, and ultrasonically treating to obtain a uniform silver ink; in the silver ink, the content of concentrated silver nanocolloid is 25wt%-55wt%, the content of ethyl cellulose is 4wt%-6wt%, and the remainder is α-terpineol; using a sizing machine to spin-coat the silver ink onto a clean polished silicon wafer, and vacuum drying to obtain a silver ink film.

The application discloses a preparation method of a rat and termite prevention foam material and relates to the technical field of foam materials. The rat and termite prevention foam material comprises the following raw materials in parts by weight: 20-30 parts of water-based acrylic resin emulsion, 50-70 parts of deionized water, 0.1-1.0 parts of capsaicin, 3-10 parts of an alcohol solvent, 2-5 parts of alkali, 0.1-2 parts of a thickening agent, 1.0-5.0 parts of a surfactant, 0.1-1.0 parts of a slow-release agent, 0.1-1.0 parts of a preservative, 5-20 parts of a propellant, 1-2 parts of melamine, 0.5-1 part of formaldehyde, 3-8 parts of a dispersing agent, 10-20 parts of an arabic gum modified melamine resin prepolymer solution and 3-5 parts of hydrochloric acid. The stimulating odor molecules are encapsulated and wrapped during the preparation process, the stimulating gas volatilization of capsaicin and alkali substances is inhibited, the gas diffusion of the obtained rat and termite prevention foam after spraying is prolonged, the gas molecules are more uniformly dispersed after the preparation of the subsequent rat and termite prevention foam and the spraying of the rat and termite prevention foam to the spraying area, and the rat and termite prevention effect is improved.

The invention discloses a gel composition for cleaning capsaicin on a skin surface and application of the gel composition. The gel composition comprises an organic solvent, a surfactant, ethyl oleate, menthol, a gel matrix and water, the gel composition is used again after the capsaicin is applied to the skin surface for a proper time, so that the side effects generated by the capsaicin are reduced.