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Magnetic capsaicin molecularly imprinted polymer and preparation method thereof

A molecular imprinting and capsaicin technology, applied in chemical instruments and methods, other chemical processes, etc., can solve problems such as unfavorable trace detection, increase analysis time, template molecule leakage, etc., to shorten processing time, simplify pretreatment steps, Identify fast effects

Active Publication Date: 2020-04-10
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the imprinted polymers prepared by traditional methods, part of the recognition sites are located inside the polymer and buried too deep, which makes it difficult to elute the template molecules, resulting in the leakage of the template molecules, which is not conducive to trace detection; when the polymer and the template molecules recombine , due to the large mass transfer resistance, the binding rate is low and the analysis time is increased

Method used

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  • Magnetic capsaicin molecularly imprinted polymer and preparation method thereof
  • Magnetic capsaicin molecularly imprinted polymer and preparation method thereof
  • Magnetic capsaicin molecularly imprinted polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Capsaicin Magnetic Molecularly Imprinted Polymer

[0024] Fe 3 o 4 Silanization: take 0.4g Fe 3 o 4 , add 100mL isopropanol and 8mL distilled water, after ultrasonic dispersion, add 5mL ammonia water and 1mL tetraethyl silicate (TEOS) drop by drop, and mechanically stir at room temperature for 12h. Washed several times with ethanol and deionized water respectively, the prepared Fe 3 o 4 @SiO 2 . Collected with a magnet, dried in vacuum at 45°C for later use.

[0025] Fe 3 o 4 @SiO 2 Surface grafting: In order to make the surface of magnetic nanoparticles have connection sites, the particle surface needs to be modified by grafting. Take 0.5g Fe 3 o 4 @SiO 2 , was added to 50mL of anhydrous toluene, and after ultrasonic dispersion was uniform, 10mL of 3-(methacryloyloxy)propyltrimethoxysilane (MPS) was added dropwise, and N 2 O was removed after 30 min 2 , sealed, and stirred in a 50°C water bath for 24h. Washed several times with toluene ...

Embodiment 2

[0028] Fe 3 o 4 Silanization: Take 0.2g Fe 3 o 4 , add 100mL isopropanol and 8mL distilled water, after ultrasonic dispersion, add 5mL ammonia water and 1mL tetraethyl silicate (TEOS) drop by drop, and mechanically stir at room temperature for 12h. Washed several times with ethanol and deionized water respectively, the prepared Fe 3 o 4 @SiO 2 . Collected with a magnet, dried in vacuum at 45°C for later use.

[0029] Fe 3o 4 @SiO 2 Surface grafting: In order to make the surface of magnetic nanoparticles have connection sites, the particle surface needs to be modified by grafting. Take 0.5g Fe 3 o 4 @SiO 2 , was added to 50mL of anhydrous toluene, and after ultrasonic dispersion was uniform, 10mL of 3-(methacryloyloxy)propyltrimethoxysilane (MPS) was added dropwise, and N 2 O was removed after 30 min 2 , sealed, and stirred in a 50°C water bath for 24h. Washed several times with toluene and ethanol to obtain Fe 3 o 4 @MPS, sucked by magnet, dried in vacuum at...

Embodiment 3

[0032] Fe 3 o 4 Silanization: Take 0.6g Fe 3 o 4 , add 100mL isopropanol and 8mL distilled water, after ultrasonic dispersion, add 5mL ammonia water and 1mL tetraethyl silicate (TEOS) drop by drop, and mechanically stir at room temperature for 12h. Washed several times with ethanol and deionized water respectively, the prepared Fe 3 o 4 @SiO 2 . Collected with a magnet, dried in vacuum at 45°C for later use.

[0033] Fe 3 o 4 @SiO 2 Surface grafting: In order to make the surface of magnetic nanoparticles have connection sites, the particle surface needs to be modified by grafting. Take 0.5g Fe 3 o 4 @SiO 2 , was added to 50mL of anhydrous toluene, and after ultrasonic dispersion was uniform, 10mL of 3-(methacryloyloxy)propyltrimethoxysilane (MPS) was added dropwise, and N 2 O was removed after 30 min 2 , sealed, and stirred in a 50°C water bath for 24h. Washed several times with toluene and ethanol to obtain Fe 3 o 4 @MPS, sucked by magnet, dried in vacuum a...

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Abstract

The invention discloses a magnetic capsaicin molecularly imprinted polymer and a preparation method thereof. A surface molecular imprinting technology is adopted, magnetic Fe3O4 nanoparticles are usedas a carrier, and molecular imprinting is carried out on the surface of the carrier. The defects of deep recognition sites, difficulty in elution of template molecules, large mass transfer resistance, low binding rate and the like in a traditional method are overcome, the prepared polymer has high recognition speed on the template molecules and certain magnetism, rapid separation can be realizedunder the condition of an external magnetic field, the pretreatment steps are greatly simplified, and the treatment time is shortened.

Description

technical field [0001] The invention specifically relates to a magnetic capsaicin molecularly imprinted polymer and a preparation method thereof. Capsaicin magnetic molecularly imprinted polymer was prepared by surface imprinting technology, and the polymer has specific adsorption for capsaicin. Background technique [0002] The traditional preparation methods of capsaicin are solvent extraction and macroporous resin chromatography column purification. These traditional adsorbents have poor selectivity and long separation time. As a new type of adsorption material, molecularly imprinted polymers have good affinity and selectivity for target molecules, and have the ability to enrich target molecules. Compared with traditional adsorption materials, MIPs have the characteristics of predetermined structure, specific recognition, wide practicability and high stability, and become a new type of adsorption materials and have been widely used. [0003] Generally, the molecular imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F226/06C08F212/36C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F292/00C08J9/26C08F226/06C08F212/36
Inventor 王海翔朱华王岁楼陈贵堂曹崇江
Owner CHINA PHARM UNIV
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