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Biocompatible antibacterial film and preparation method thereof

A technology of biocompatibility and thin film, which is applied in the field of biocompatible antibacterial film and its preparation, can solve the problems of poor water barrier rate, limited application, poor mechanical properties, etc., and achieve antibacterial and elongation at break, preparation The effect of simple process and excellent mechanical properties

Pending Publication Date: 2021-08-31
ZHEJIANG CHENGDE PACKAGING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor solubility of chitosan in water and organic solvents limits its application.
[0004] Common films based on biomacromolecules have the characteristics of low production cost, good biocompatibility, biodegradability and easy processing, but the single-component films have poor mechanical properties, oxygen barrier properties, and water barrier properties. Can not meet the requirements of the wide application of food packaging film
[0005] Chinese patent CN105001463A discloses the preparation of a gelatin-chitosan composite film. In this patent, the chitosan solution is mixed with gelatin to complement each other and improve gelatin’s shortcomings of poor film-forming and mechanical properties and chitosan’s poor water vapor resistance. However, the chitosan used in this invention has a small solubility in water, and chitosan itself has a regular molecular structure and poor mechanical properties. It is compared with gelatin with poor mechanical properties. Therefore, the mechanical properties and antibacterial properties of gelatin-chitosan composite films still need to be further improved and strengthened.
[0006] Chinese patent CN109627474A discloses the preparation method of nanocellulose-chitosan-gelatin composite membrane, and this invention uses nanocellulose as dispersed phase to strengthen the mechanical property of chitosan-gelatin composite membrane, but nanocellulose and gelatin, shell The compatibility between polysaccharides is insufficient. The compatibility between nanofibers, chitosan and polyvinyl alcohol is due to the strong hydrogen bond interaction between nanocellulose, chitosan and polyvinyl alcohol. The presence of bonds improves the thermal stability of chitosan, reduces the crystallinity of polyvinyl alcohol, promotes the compatibility of nanocellulose, chitosan and polyvinyl alcohol, and the gelatin-chitosan film has low elasticity and is brittle
Chinese patent CN106867042A discloses casting method to prepare nanocellulose / chitosan / polyvinyl alcohol composite film and its application in biological antibacterial film, but it still does not improve the water solubility of chitosan

Method used

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  • Biocompatible antibacterial film and preparation method thereof

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Embodiment 1

[0029] A kind of biocompatible antibacterial film and preparation method thereof

[0030] Biocompatible antibacterial film, the biocompatible antibacterial film comprises the following components by mass: modified polyvinyl alcohol 60g, starch 25g; modified chitosan 25g; capsaicin 4gg, glycerin 12gg.

[0031] The preparation of above-mentioned modified chitosan comprises the following steps:

[0032] S1, at room temperature, dissolve chitosan in distilled water, add 6% acetic acid solution dropwise to adjust the pH to 4, stir at 45°C for 30 minutes to dissolve chitosan evenly, and obtain a shell with a concentration of 1.5wt%. Polysaccharide solution: Dissolve glycidyltrimethylammonium chloride in distilled water, stir magnetically to dissolve glycidyltrimethylammonium chloride evenly, and obtain glycidyltrimethylammonium chloride with a concentration of 0.2mol / L ammonium chloride solution;

[0033] S2, Slowly add glycidyltrimethylammonium chloride solution to the chitosan s...

Embodiment 2

[0039] A kind of biocompatible antibacterial film and preparation method thereof

[0040] Biocompatible antibacterial film, the biocompatible antibacterial film comprises the following components by mass: modified polyvinyl alcohol 65g, starch 28g; modified chitosan 30g; capsaicin 5g, glycerin 14g.

[0041] The preparation of above-mentioned modified chitosan comprises the following steps:

[0042] S1, at room temperature, dissolve chitosan in distilled water, add dropwise 6% acetic acid solution to adjust the pH to 4, stir at 45°C for 35min, dissolve chitosan evenly, and obtain a shell with a concentration of 1.8wt%. Polysaccharide solution: Dissolve glycidyltrimethylammonium chloride in distilled water, stir magnetically to dissolve glycidyltrimethylammonium chloride evenly, and obtain glycidyltrimethylammonium chloride with a concentration of 0.3mol / L ammonium chloride solution;

[0043] S2, Slowly add glycidyltrimethylammonium chloride solution to the chitosan solution d...

Embodiment 3

[0049] A kind of biocompatible antibacterial film and preparation method thereof

[0050] Biocompatible antibacterial film, the biocompatible antibacterial film comprises the following components by mass: modified polyvinyl alcohol 70g, starch 300g; modified chitosan 40g; capsaicin 8g, glycerin 20g.

[0051] The preparation of above-mentioned modified chitosan comprises the following steps:

[0052] S1, at room temperature, dissolve chitosan in distilled water, add dropwise 6% acetic acid solution to adjust the pH to 5, stir at 55°C for 35min, dissolve chitosan evenly, and obtain a shell with a concentration of 2.5wt%. Polysaccharide solution: Dissolve glycidyltrimethylammonium chloride in distilled water, and magnetically stir to dissolve glycidyltrimethylammonium chloride evenly to obtain glycidyltrimethylammonium chloride with a concentration of 0.6mol / L ammonium chloride solution;

[0053] S2, slowly drop glycidyltrimethylammonium chloride solution into the chitosan solu...

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Abstract

The invention discloses a biocompatible antibacterial film and a preparation method thereof. The biocompatible antibacterial film comprises the following components: a film matrix solution, modified chitosan, capsaicin and glycerol. The film matrix solution is a mixed solution of modified polyvinyl alcohol and starch. According to the biocompatible film disclosed by the invention, polyvinyl alcohol is taken as a matrix polymer and supplemented with starch, chitosan is subjected to modification treatment, a modified chitosan / polyvinyl alcohol / starch composite film is prepared, and capsaicin with antibacterial property is added, so that the film has excellent mechanical property, thermal property, oxidation resistance, barrier property, antibacterial property and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of film materials, in particular to a biocompatible antibacterial film and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards, people's awareness of the living environment, especially the safety awareness of food and medicine has been continuously enhanced. The growth and reproduction of microorganisms is not only an important cause of product rot and deterioration, but also some microorganisms can cause great harm to the human body. Therefore, product packaging films with antibacterial properties have received extensive attention. In addition, petroleum-based non-biodegradable materials seriously pollute the environment and cannot meet the environmental protection requirements of green and sustainable development. [0003] Currently, research on antimicrobial agents in films, coatings, and packaging is mainly focused on the use of...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L67/04C08L3/02C08L3/08C08L5/08C08K5/20C08K5/053C08J5/18C08B37/08
CPCC08J5/18C08B37/003C08J2329/04C08J2467/04C08J2403/02C08J2403/08C08J2405/08C08K5/20C08K5/053C08J2303/02C08J2303/08C08J2429/04
Inventor 吴连球徐子状詹先文陈鹏
Owner ZHEJIANG CHENGDE PACKAGING
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