Exterior medicine composition of fluocinolone acetonide and ester of fluocinolone acetonide

A composition, fluocinolone technology, applied in the directions of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problems of blood calcium reduction, convulsions, death, etc.

Active Publication Date: 2013-05-15
天津金耀药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it should be pointed out that patients with lead poisoning who should be treated with edetate calcium and sodium, especially children, may cause serious decrease in blood calcium, convulsions and even death due to misuse of edetate disodium

Method used

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  • Exterior medicine composition of fluocinolone acetonide and ester of fluocinolone acetonide
  • Exterior medicine composition of fluocinolone acetonide and ester of fluocinolone acetonide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0046] Fluocinolone acetate 0.25g, dimethyl sulfoxide 15g, white petrolatum 100g, stearyl alcohol 90g, liquid paraffin 50g,

[0047] Sodium Lauryl Sulfate 50g, Glycerin 50g, Ethyl p-hydroxybenzoate 1g,

[0048] Add edetate disodium 0.1g to 1000g with water for injection,

[0049] Accurately weighed according to the above ratio, the cream preparation process is as follows:

[0050] 1) Mix sodium lauryl sulfate, edetate, ethyl p-hydroxybenzoate, glycerin and distilled water and heat to 70°C;

[0051] 2) Dissolve the prescribed amount of fluocinolone acetate in the prescribed amount of dimethyl sulfoxide;

[0052] 3) Heat stearyl alcohol, white petrolatum, and liquid paraffin in the prescribed amount to 80°C, slowly add the mixture obtained in step 1) and stir quickly, then add the fluocinolone dimethyl sulfoxide solution in step 3), mix well, and condense into paste. Cream fluocinolone acetate content 0.025%

Embodiment 1-2

[0054] According to the recipe and process of Example 1-1, the amount of disodium edetate was changed to 0.25g.

Embodiment 1-3

[0056] According to the recipe and process of Example 1-1, the amount of edetate disodium was changed to 1 g.

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PUM

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Abstract

The invention provides an exterior medicine composition of fluocinolone acetonide and ester of fluocinolone acetonide. The exterior medicine composition comprises the fluocinolone acetonide or the ester of the fluocinolone acetonide serving as the active component, and one or more auxiliary materials applied to skin; and the exterior medicine composition is characterized in that the auxiliary materials for skin include sodium calcium edetate or edetate disodium.

Description

technical field [0001] The invention relates to a cream of fluocinolone and its esters. Background technique [0002] The chemical name of fluocinolone is 11β, 21-dihydroxy-16α,17-[(1-methylethylene)-bis(oxygen)]-6α,9-difluoropregna-1,4-diene- 3,20-diketone, CAS No is 67-73-2, the chemical name of fluocinolone acetate is 11β-hydroxy-16α,17-[(1-methylethylene)-bis(oxygen)]-21- (Acetoxy)-6α,9-difluoropregna-1,4-diene-3,20-dione, CAS No: 356-12-7, fluocinonide acetate is the 21-position acetate of fluocinonide, All belong to adrenal cortex hormone drugs. External application can shrink dermal capillaries, inhibit the proliferation or regeneration of epidermal cells, inhibit the regeneration of fibroblasts in connective tissue, stabilize intracellular lysosomal membranes, and prevent tissue damage caused by the release of lysosomal enzymes. It has strong anti-inflammatory and anti-allergic effects. For allergic dermatitis, atopic dermatitis, contact dermatitis, seborrheic der...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/08A61K9/12A61K9/10A61K31/58A61K47/18A61P17/00A61P37/08
Inventor 陈松赵琳孙亮
Owner 天津金耀药业有限公司
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