Compound monoammonium glycyrrhizunate S prepn for injection and its prepn process and quality control technology

A technology of monoammonium glycyrrhizinate and compound licorice, applied in the field of medicine, can solve problems such as insufficient standardization of clinical treatment, achieve the effects of significant curative effect, reduce pollution, and avoid intermediate links

Inactive Publication Date: 2005-12-14
余世春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are many drugs for the treatment of chronic hepatitis, such as interferon, ciclovir, lamivudine, etc., and hundre

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  • Compound monoammonium glycyrrhizunate S prepn for injection and its prepn process and quality control technology

Examples

Experimental program
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Effect test

Embodiment Construction

[0117] prescription

[0118] Monoammonium Glycyrrhizinate S 40g

[0119] Cysteine ​​hydrochloride 30g

[0120] Glycine 400g

[0121] Sodium bisulfite 10g

[0122] Edetate Disodium 1g

[0123] Mannitol 100g

[0124] Add water for injection to 5000ml

[0125] Makes 1000 bottles

[0126] Preparation Process

[0127] Weigh monoammonium glycyrrhizinate, cysteine ​​hydrochloride, glycine, and mannitol in a clean room, place them in a sterilized container, add 4500ml of water for injection, stir to dissolve, then add sodium bisulfite, edetic acid Stir the disodium to dissolve, adjust the pH with 1mol / ml sodium hydroxide, then add 5g of 767 type activated carbon for needles, stir for 30 minutes, filter and decarbonize with a sterile suction filtration device, add water for injection to a quantitative level (containing glycyrrhizic acid) Ammonium monoammonium 8mg / ml, cysteine ​​hydrochloride 6mg / ml, glycine 80mg / ml), test the sample content, after the p...

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Abstract

The compound monoammonium glycyrrhizunate S preparation is injection or freeze dried powder preparation compounded with monoammonium glycyrrhizunate S, cysteine hydrochloride, glycine, sodium bisulfite, disodium versenate and mannitol in certain proportion. The present invention also discloses the preparation process and quality control technology. The compound monoammonium glycyrrhizunate S injection preparation is used in treating skin diseases and viral hepatitis mainly, and may be also used in treating acute and chronic unresolved hepatitis, poisoning hepatitis, etc. to result in certain curative effect. Recently, it is also in treating epidemic hemorrhagic fever, epidemic encephalitis, pulmonary tuberculosis, etc and thus has expanded clinical application range.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to compound monoammonium glycyrrhizinate S preparation for injection, a preparation method and quality control technology. Background technique: [0002] Hepatitis is an infectious disease with a high incidence worldwide, especially in East Asia and Southeast Asia. About 300 million people in the world are suffering from liver diseases. my country is a high-incidence area of ​​hepatitis disease, with about 2 million cases of acute hepatitis and about 30 million patients with chronic hepatitis B each year. Chronic hepatitis is very harmful. First, it can transmit the virus to others through blood, and second, it can stimulate liver fibrosis. At present, there are many drugs for the treatment of chronic hepatitis, such as interferon, ciclovir, lamivudine, etc., and hundreds of enzyme-lowering drugs. However, the clinical treatment is not standardized enough, and the phenomenon of drug abuse ...

Claims

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Application Information

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IPC IPC(8): A61K31/704
Inventor 余世春
Owner 余世春
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