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Nano-emulsion medicine for treating foot rot and preparation method thereof

A technology of nanoemulsion and foot rot, which is applied in the direction of drug combination, medical raw materials derived from gymnosperm subphylum, skin diseases, etc., which can solve the problem of unsatisfactory drug stability, low utilization rate of drug solution, strong local stimulation, etc. problem, to achieve good transdermal efficacy, improve bioavailability, and obvious absorption effect

Inactive Publication Date: 2012-07-11
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether it is ointment or various compound preparations, there are disadvantages such as low skin penetration rate, low bioavailability, and unsatisfactory drug stability.
In veterinary clinics, pine distilled oil stock solution is often used to treat animal foot rot, but the stock solution is very viscous and inconvenient to use, the utilization rate of the liquid is not high, and the local stimulation effect is strong

Method used

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  • Nano-emulsion medicine for treating foot rot and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] A kind of nanoemulsion medicine for the treatment of foot rot, the quality of each component:

[0073] Pine Distillate Oil 5.0g, Cinnamaldehyde 0.5g, Carvacrol 0.5g, Camphor Oil 0.2g, Clobetasol Propionate 0.05g, Polyoxyethylene (40) Hydrogenated Castor Oil (RH-40) 20.0g, Polyoxygen Vinyl ether castor oil (EL-40) 7.0g, absolute ethanol 4.0g, distilled water 62.75g.

[0074] Above-mentioned each component is made a kind of nanoemulsion medicine that is used for the treatment of foot rot, comprises the following steps:

[0075] 1) Accurately weigh polyoxyethylene (40) hydrogenated castor oil (RH-40), polyoxyethylene ether castor oil (EL-40), absolute ethanol, pine distillate oil, cinnamaldehyde, carvacrol, camphor according to the formula oil, clobetasol propionate and distilled water, for later use;

[0076] 2) Mix the said amount of pine distillate oil, cinnamaldehyde, carvacrol, and camphor oil and stir well, then dissolve the said amount of clobetasol propionate in ...

Embodiment 2

[0080] A kind of nanoemulsion medicine for the treatment of foot rot, the quality of each component:

[0081] Pine distillate oil 4.5g, cinnamaldehyde 1.0g, carvacrol 0.5g, camphor oil 0.1g, clobetasol propionate 0.01g, polyoxyethylene (40) hydrogenated castor oil (RH-40) 25.0g, anhydrous Ethanol 3.0g, distilled water 65.89g.

Embodiment 3

[0083] A kind of nanoemulsion medicine for the treatment of foot rot, the quality of each component:

[0084] Pine Distillate Oil 10.0g, Cinnamaldehyde 0.1g, Carvacrol 0.1g, Camphor Oil 0.1g, Clobetasol Propionate 0.05g, Polyoxyethylene (40) Hydrogenated Castor Oil (RH-40) 24.0g, Polyoxygen Vinyl ether castor oil (EL-40) 5.0g, distilled water 60.65g.

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Abstract

The invention discloses a nano-emulsion medicine for treating foot rot. The grain diameter of the nano-emulsion is in a range of 1-100 nanometers and the nano-emulsion is composed of the following raw materials: 0.1-10.0% of pine tar, 0.1-6.0% of cinnamyl aldehyde, 0.1-6.0% of carvacrol, 0.1-5.0% of camphor oil, 0.01-0.1% of clobetasol propionate, 18.0-35.0% of surfactant, 0-7.0% of co-surfactant and residual amount of distilled water; and the sum of the mass percentages of the components is 100%. The nano-emulsion disclosed by the invention has the functions of dissolving cutin, relieving itching, diminishing inflammation, restraining, partially disinfecting and resisting corrosion, accelerating absorption and the like, and is mainly used for treating animal foot rot. According to the nano-emulsion medicine for treating the foot rot, the solubility of the medicine is increased, the medicinal stability and the biological utilization rate are improved, the dosage of the medicine is reduced, the skin transmission rate is higher than that of common preparations including a medicinal extract and the like, and the cost is low, so that the nano-emulsion medicine has a wide market prospect in a veterinary medicine field.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a new drug dosage form which can be used for treating animal foot rot, in particular to a nanoemulsion medicine for treating foot rot and a preparation method thereof. Background technique [0002] Foot rot is a common and frequently-occurring disease in animal breeding and production, showing a high incidence in various parts of our country. The main reason is that the hooves are soaked in feces and urine for a long time, which softens the cutin of the hoofs, infects necrosis bacteria, and promotes interhoof rot. Animals have difficulty in walking and moving, lying on the ground for a long time, reduced mobility, often raising the affected hoof, inconvenient feeding, and can't compete with other healthy animals in the same tank. Over time, they will become severely emaciated and affect the production capacity of the animal. Stones, nails and other foreign objects on the ground c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61K9/107A61P31/04A61P17/00A61K31/11A61K31/05
Inventor 欧阳五庆郭建军欧阳伸雨
Owner NORTHWEST A & F UNIV
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