External ointment with treatment and health-care effects and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine ointment, and provides external ointment with treatment and health care effects and a preparation method. Comprising 80-120 parts of vaseline, 6-20 parts of glycerin, 6-20 parts of paraffin, 5-15 parts of an antioxidant, 2-8 parts of a cortex phellodendri extract, 2-10 parts of a radix angelicae extract, 2-8 parts of a fructus cnidii extract, 2-10 parts of a radix sophorae flavescentis extract, 2-8 parts of a polygonum cuspidatum extract, 300-400 parts of water, 8-20 parts of borneol, 8-20 parts of camphor, 8-20 parts of mentholum, 7-20 parts of vitamin B, 12-10 parts of vitamin B, 15-45 parts of honey, 2-10 parts of vinegar, 10-20 parts of an anti-inflammatory agent and 15-25 parts of a fixing agent. Aiming at patients with neurodermatitis, eczema of hands and feet, tinea of hands and feet, tinea manuum, pustular herpes of palms and toes, eczema, rhagadia of hands and feet and skin itch, the traditional Chinese medicine composition has the effect of promoting recovery and health by being externally applied to the affected part.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine ointments, in particular to an external ointment with therapeutic and health-care effects and a preparation method thereof. Background Art

[0002] The ingredients of the present invention, including Chinese herbal extracts, plant oils, and compounds, are complex to prepare, prone to uneven mixing, and ineffective ingredients due to poor temperature control during the preparation process. Existing Chinese herbal ointments for skin diseases have limited efficacy and are relatively targeted, but their efficacy is somewhat insufficient for most skin conditions. They also have a low cure rate and are prone to recurrence. Summary of the Invention

[0003] The purpose of the present invention is to provide an external ointment with therapeutic and health-care effects and a preparation method thereof, so as to overcome the defects of the prior art.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The present invention provides an externally applied ointment with therapeutic and health-care effects, which is prepared from the following raw materials in parts by weight: 20 to 30 parts of an oil mixture, 70 to 80 parts of an aqueous mixture, and 1 to 5 parts of a fixative;

[0006] The oil mixture comprises 80-120 parts of vaseline, 6-20 parts of glycerin, 6-20 parts of paraffin, 5-15 parts of antioxidant, 2-8 parts of Phellodendron amurense extract, 2-10 parts of Angelica dahurica extract, 2-8 parts of Cnidium monnieri extract, 2-10 parts of Sophora flavescens extract, and 2-8 parts of Polygonum cuspidatum extract;

[0007] The aqueous mixture comprises 300-400 parts of water, 8-20 parts of borneol, 8-20 parts of camphor, 8-20 parts of mint ice, 7-20 parts of vitamin B6, 2-10 parts of vitamin B1, 15-45 parts of honey, 2-10 parts of vinegar, and 10-20 parts of anti-inflammatory agent;

[0008] The fixing agent is 15 to 25 parts.

[0009] Preferably, the anti-inflammatory agent is glycyrrhizic acid and / or dihydroavenous alkaloid.

[0010] Preferably, the antioxidant is corn oil and / or sesame oil.

[0011] Preferably, the fixing agent is carbomer.

[0012] The present invention also provides a method for preparing an externally applied ointment having therapeutic and health-care effects, comprising the following steps:

[0013] (1) Mixing the raw materials of the oil mixture and heating them to 80-110° C. to fully dissolve and obtain the oil mixture;

[0014] (2) mixing the aqueous mixture raw materials to obtain an aqueous mixture;

[0015] (3) The oil mixture and the water mixture are mixed to obtain an oil-water mixture, and after stirring evenly, a fixing agent is poured into the mixture to mix and fix it into a paste, thereby obtaining the externally applied paste with therapeutic and health-care effects.

[0016] Preferably, the mixing temperature in step (2) is 20-45°C.

[0017] Preferably, the mixing temperature in step (3) is independently 30-45°C.

[0018] Preferably, the mixing rate is independently 750-850 r / min.

[0019] Preferably, the mixing time in step (3) is independently 10 to 15 minutes.

[0020] Beneficial effects:

[0021] The present invention provides a topical cream for treatment and health care, as well as a preparation method. The cream comprises Chinese herbal extracts, plant oils, and compounds. The cream contains Phellodendron amurense extract, Angelica dahurica extract, Cnidium monnieri extract, Sophora flavescens extract, Polygonum cuspidatum extract, honey, borneol, camphor, menthol ice, corn oil, water, vinegar, petrolatum, glycerin, paraffin, vitamin B6, vitamin B1, glycyrrhizic acid or dihydroavenous alkaloids, and carbomer. The cream is made of carefully selected ingredients and is safe and reliable. By applying the cream to the affected area, it promotes recovery and health. The cream is targeted at patients with neurodermatitis, hand and foot eczema, tinea pedis, tinea manuum, palmar and toe pustulosis, eczema, chapped hands and feet, and itchy skin. It exhibits the typical characteristics of anti-inflammatory, antipruritic, rapid skin lesion repair, and no toxic side effects. Furthermore, it has a low probability of recurrence, bringing benefits to those suffering from skin problems. DETAILED DESCRIPTION

[0022] The present invention provides an externally applied ointment with therapeutic and health-care effects, which is prepared from the following raw materials in parts by weight: 20 to 30 parts of an oil mixture, 70 to 80 parts of an aqueous mixture, and 1 to 5 parts of a fixative;

[0023] The oil mixture comprises 80-120 parts of vaseline, 6-20 parts of glycerin, 6-20 parts of paraffin, 5-15 parts of antioxidant, 2-8 parts of Phellodendron amurense extract, 2-10 parts of Angelica dahurica extract, 2-8 parts of Cnidium monnieri extract, 2-10 parts of Sophora flavescens extract, and 2-8 parts of Polygonum cuspidatum extract;

[0024] The aqueous mixture comprises 300-400 parts of water, 8-20 parts of borneol, 8-20 parts of camphor, 8-20 parts of mint ice, 7-20 parts of vitamin B6, 2-10 parts of vitamin B1, 15-45 parts of honey, 2-10 parts of vinegar, and 10-20 parts of anti-inflammatory agent;

[0025] The fixing agent is 15 to 25 parts.

[0026] In the present invention, the ointment contains 20 to 30 parts of the oil mixture, preferably 21 to 29 parts, more preferably 22 to 28 parts, and even more preferably 23 to 27 parts.

[0027] In the present invention, the ointment contains 70 to 80 parts of the aqueous mixture, preferably 71 to 79 parts, more preferably 72 to 78 parts, and even more preferably 73 to 77 parts.

[0028] In the present invention, the ointment contains 1 to 5 parts of the fixing agent, preferably 2 to 4 parts, more preferably 2.5 to 3.5 parts, and even more preferably 3 parts.

[0029] In the present invention, the oil mixture contains 80 to 120 parts of vaseline, preferably 85 to 115 parts, more preferably 90 to 110 parts, and even more preferably 95 to 105 parts.

[0030] In the present invention, the oil mixture contains 6 to 20 parts of glycerin, preferably 8 to 18 parts, more preferably 10 to 16 parts, and even more preferably 12 to 14 parts.

[0031] In the present invention, the oil mixture contains 6 to 20 parts of paraffin wax, preferably 8 to 18 parts, more preferably 10 to 16 parts, and even more preferably 12 to 14 parts.

[0032] In the present invention, the oil mixture contains 5 to 15 parts of antioxidant, preferably 6 to 14 parts, more preferably 7 to 12 parts, and even more preferably 8 to 10 parts.

[0033] In the present invention, the oil mixture contains 2 to 8 parts of Phellodendron amurense extract, preferably 3 to 7 parts, more preferably 4 to 6 parts, and even more preferably 5 parts.

[0034] In the present invention, the oil mixture contains 2 to 10 parts of Angelica dahurica extract, preferably 3 to 9 parts, more preferably 4 to 8 parts, and even more preferably 5 to 7 parts.

[0035] In the present invention, the oil mixture contains 2 to 8 parts of Cnidium monnieri extract, preferably 3 to 7 parts, more preferably 4 to 6 parts, and even more preferably 5 parts.

[0036] In the present invention, the oil mixture contains 2 to 10 parts of Sophora flavescens extract, preferably 3 to 9 parts, more preferably 4 to 8 parts, and even more preferably 5 to 7 parts.

[0037] In the present invention, the oil mixture contains 2 to 8 parts of the knotweed extract, preferably 3 to 7 parts, more preferably 4 to 6 parts, and even more preferably 5 parts.

[0038] In the present invention, the aqueous mixture contains 300 to 400 parts of water, preferably 310 to 390 parts, more preferably 320 to 380 parts, and even more preferably 330 to 370 parts.

[0039] In the present invention, the aqueous mixture contains 8 to 20 parts of borneol, preferably 10 to 18 parts, more preferably 12 to 16 parts, and even more preferably 13 to 15 parts.

[0040] In the present invention, the aqueous mixture contains 8 to 20 parts of camphor, preferably 10 to 18 parts, more preferably 12 to 16 parts, and even more preferably 13 to 15 parts.

[0041] In the present invention, the aqueous mixture contains 8 to 20 parts of mint ice, preferably 10 to 18 parts, more preferably 12 to 16 parts, and even more preferably 13 to 15 parts.

[0042] In the present invention, the aqueous mixture contains 7 to 20 parts of vitamin B6, preferably 8 to 18 parts, more preferably 10 to 16 parts, and even more preferably 12 to 14 parts.

[0043] In the present invention, the aqueous mixture contains 2 to 10 parts of vitamin B1, preferably 3 to 9 parts, more preferably 4 to 8 parts, and even more preferably 5 to 7 parts.

[0044] In the present invention, the aqueous mixture contains 15 to 45 parts of honey, preferably 20 to 40 parts, more preferably 23 to 38 parts, and even more preferably 25 to 35 parts.

[0045] In the present invention, the aqueous mixture contains 2 to 10 parts of vinegar, preferably 3 to 9 parts, more preferably 4 to 8 parts, and even more preferably 5 to 7 parts.

[0046] In the present invention, the aqueous mixture contains 10 to 20 parts of the anti-inflammatory agent, preferably 11 to 19 parts, more preferably 12 to 18 parts, and even more preferably 13 to 17 parts.

[0047] In the present invention, the paste contains 15 to 25 parts of the fixing agent, preferably 16 to 24 parts, more preferably 17 to 23 parts, and even more preferably 18 to 21 parts.

[0048] In the present invention, the anti-inflammatory agent is glycyrrhizic acid and / or dihydroavenate alkaloids.

[0049] In the present invention, the antioxidant is corn oil and / or sesame oil.

[0050] In the present invention, the fixing agent is carbomer.

[0051] The present invention also provides a method for preparing an externally applied ointment having therapeutic and health-care effects, comprising the following steps:

[0052] (1) Mixing the raw materials of the oil mixture and heating them to 80-110° C. to fully dissolve and obtain the oil mixture;

[0053] (2) mixing the aqueous mixture raw materials to obtain an aqueous mixture;

[0054] (3) The oil mixture and the water mixture are mixed to obtain an oil-water mixture, and after stirring evenly, a fixing agent is poured into the mixture to mix and fix it into a paste, thereby obtaining the externally applied paste with therapeutic and health-care effects.

[0055] In the present invention, the mixing temperature in step (2) is 20-45°C, preferably 22-43°C, more preferably 25-40°C, and even more preferably 30-35°C.

[0056] In the present invention, the mixing temperature in step (3) is independently 30 to 45°C, preferably 32 to 43°C, more preferably 34 to 40°C, and even more preferably 35 to 39°C.

[0057] In the present invention, the mixing rate is independently 750 to 850 r / min, preferably 770 to 840 r / min, more preferably 780 to 830 r / min, and even more preferably 790 to 820 r / min.

[0058] In the present invention, the mixing time in step (3) is independently 10 to 15 minutes, preferably 11 to 14 minutes, and more preferably 12 to 13 minutes.

[0059] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0060] Example 1

[0061] Step 1: Preparation of oil mixture: Melt 80g of vaseline to make vaseline, lower the temperature of the melted vaseline liquid to 80°C, pour in 6g of glycerin, 6g of paraffin, 10g of corn oil, 2g of Phellodendron amurense extract, 2g of Angelica dahurica extract, 2g of Cnidium monnieri extract, 2g of Sophora flavescens extract, and 2g of Polygonum cuspidatum extract.

[0062] Step 2: Preparation of aqueous mixture: Pour 8g borneol, 8g camphor, 8g mint ice, 7g vitamin B6, 3g vitamin B1, 15g honey, 2g vinegar, and 10g glycyrrhizic acid into 300g water at 40℃ and dissolve them.

[0063] Step 3: Lower the temperature of the oil mixture to about 45°C and mix it with the water mixture, stirring quickly until evenly mixed.

[0064] Step 4: Pour 18 g of carbomer into the oil-water mixture at 45° C., stir at 800 rpm for 15 minutes, and after cooling, form a paste and bottle to obtain a finished ointment.

[0065] Example 2

[0066] Step 1: Preparation of oil mixture: Melt 90g of vaseline to make vaseline, lower the temperature of the melted vaseline liquid to 90°C, pour in 8g of glycerin, 8g of paraffin, 15g of corn oil, 4g of Phellodendron amurense extract, 4g of Angelica dahurica extract, 4g of Cnidium monnieri extract, 4g of Sophora flavescens extract, and 4g of Polygonum cuspidatum extract.

[0067] Step 2: Preparation of aqueous mixture: Pour 12g borneol, 12g camphor, 12g mint ice, 10g vitamin B6, 5g vitamin B1, 25g honey, 25g vinegar, and 15g dihydroaat alkaloid into 310g water at 25℃ and dissolve them.

[0068] Step 3: Lower the temperature of the oil mixture to about 40°C and mix it with the water mixture, stirring quickly until evenly mixed.

[0069] Step 4: Pour 20 g of carbomer into the oil-water mixture at 40° C., stir at 750 rpm for 10 minutes, and after cooling, form a paste and bottle to obtain a finished ointment.

[0070] Example 3

[0071] Step 1: Preparation of oil mixture: Melt 120g of vaseline to make vaseline, lower the temperature of the melted vaseline liquid to 100°C, pour in 15g of glycerin, 15g of paraffin, 10g of sesame oil, 4g of Phellodendron amurense extract, 5g of Angelica dahurica extract, 4g of Cnidium monnieri extract, 5g of Sophora flavescens extract, and 4g of Polygonum cuspidatum extract.

[0072] Step 2: Preparation of aqueous mixture: Pour 20g borneol, 20g camphor, 15g mint ice, 15g vitamin B6, 5g vitamin B1, 40g honey, 10g vinegar, and 15g glycyrrhizic acid into 375g water at 30℃ and dissolve.

[0073] Step 3: Lower the temperature of the oil mixture to 30°C and mix it with the water mixture, stirring quickly until evenly mixed.

[0074] Step 4: Pour 20 g of carbomer into the oil-water mixture at 30° C., stir at 850 rpm for 12 minutes, and after cooling, form a paste and bottle it to obtain a finished ointment.

[0075] Usage: Apply the Chinese medicine ointment evenly to the affected area with an interval of 8 hours. The course of treatment varies from 5 to 15 days depending on the patient's recovery condition.

[0076] Test Example 1

[0077] Trial population: 120 patients were recruited clinically, including 57 males and 63 females, aged 18-60 years, all suffering from eczema and hand and foot eczema.

[0078] Test groups: Example 1, Example 2, Example 3 and Reference Example (hand and foot eczema and eczema cream with good sales in the market);

[0079] Test groups: 30 patients were randomly assigned to each group;

[0080] Test content: Each group of patients applied the designated ointment on time every 8 hours every day. The treatment effect was recorded, and a follow-up visit was conducted 1 year after the cure to record whether there was any recurrence.

[0081] project Antipruritic effect (days) Recovery (days) Comprehensive cure rate Follow-up after 1 year to see if there is recurrence Example 1 1 10 95.5％ none Example 2 1 15 95.6％ none Example 3 1 22 96.6％ none Reference Example 3 30 85.2％ 30% of patients relapse

[0082] Test Example 2

[0083] Study population: 400 patients with neurodermatitis were recruited clinically, including 187 males and 213 females, aged 18-60 years.

[0084] Test groups: Example 1, Example 2, Example 3 and Reference Example (a neurodermatitis ointment with good sales in the market);

[0085] Test groups: 100 patients were randomly assigned to each group;

[0086] Test content: Each group of patients applied the designated ointment on time every 8 hours every day for 15 days, and a follow-up visit was conducted one year after cure to record any recurrence.

[0087] project Antipruritic effect (days) Recovery (days) Comprehensive cure rate Follow-up after 1 year to see if there is recurrence Example 1 1 10 97.9％ none Example 2 2 15 96.6％ none Example 3 1 22 99.1％ none Reference Example 3 30 85.2％ 30% of patients relapse

[0088] Test Example 3

[0089] Study population: 200 patients were recruited from the clinic, including 87 males and 113 females, aged 18-60 years, all suffering from tinea pedis and tinea manuum.

[0090] Test groups: Example 1, Example 2, Example 3 and Reference Example (a tinea pedis ointment with good sales in the market);

[0091] Test groups: 50 patients were randomly assigned to each group;

[0092] Test content: Each group of patients applied the designated ointment on time every 8 hours every day for 20 days, and a follow-up visit was conducted one year after cure to record any recurrence.

[0093]

[0094]

[0095] As can be seen from the above examples, the present invention is a topical cream for treatment and health care and a preparation method, comprising Chinese herbal extracts, plant oils, and compounds. The product contains Phellodendron amurense extract, Angelica dahurica extract, Cnidium monnieri extract, Sophora flavescens extract, Polygonum cuspidatum extract, honey, borneol, camphor, mentha glabra, corn oil, water, vinegar, vaseline, glycerin, paraffin, vitamin B6, vitamin B1, glycyrrhizic acid or dihydroavenous alkaloids, and carbomer. The materials used in the present invention are sophisticated, safe, and reliable. By applying the affected area externally, it has the effect of promoting recovery and health. The present invention is targeted at patients with neurodermatitis, hand and foot eczema, tinea pedis, tinea manuum, palmar toe pustular rash, eczema, chapped hands and feet, and itchy skin. It has the typical characteristics of anti-inflammatory, antipruritic, rapid skin lesion repair, and no toxic side effects, and has a low probability of recurrence, bringing good news to people suffering from skin problems.

[0096] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. An external ointment with therapeutic and health-care effects, characterized in that: The preparation method comprises the following raw materials in parts by weight: 20 to 30 parts of oil mixture, 70 to 80 parts of water mixture and 1 to 5 parts of fixing agent; The oil mixture comprises 80-120 parts of vaseline, 6-20 parts of glycerin, 6-20 parts of paraffin, 5-15 parts of antioxidant, 2-8 parts of Phellodendron amurense extract, 2-10 parts of Angelica dahurica extract, 2-8 parts of Cnidium monnieri extract, 2-10 parts of Sophora flavescens extract, and 2-8 parts of Polygonum cuspidatum extract; The aqueous mixture comprises 300-400 parts of water, 8-20 parts of borneol, 8-20 parts of camphor, 8-20 parts of mint ice, 7-20 parts of vitamin B6, 2-10 parts of vitamin B1, 15-45 parts of honey, 2-10 parts of vinegar, and 10-20 parts of anti-inflammatory agent; The fixing agent is 15 to 25 parts.

2. The external ointment with therapeutic and health-care effects according to claim 1, characterized in that: The anti-inflammatory agent is glycyrrhizic acid and / or dihydroavenous alkaloid.

3. The external ointment with therapeutic and health-care effects according to claim 1, characterized in that: The antioxidant is corn oil and / or sesame oil.

4. The external ointment with therapeutic and health-care effects according to claim 2 or 3, characterized in that: The fixing agent is carbomer.

5. A method for preparing the external ointment with therapeutic and health-care effects according to claim 1, characterized in that: The following steps are involved: (1) Mixing the raw materials of the oil mixture and heating them to 80-110° C. to fully dissolve and obtain the oil mixture; (2) mixing the aqueous mixture raw materials to obtain an aqueous mixture; (3) The oil mixture and the water mixture are mixed to obtain an oil-water mixture, and after stirring evenly, a fixing agent is poured into the mixture to mix and fix it into a paste, thereby obtaining the externally applied paste with therapeutic and health-care effects.

6. The preparation method according to claim 5, characterized in that The mixing temperature in step (2) is 20-45°C.

7. The preparation method according to claim 5, characterized in that The mixing temperature in step (3) is independently 30-45°C.

8. The preparation method according to claim 7, characterized in that The mixing rate is independently 750-850 r / min.

9. The preparation method according to any one of claims 5 to 8, characterized in that: The mixing time in step (3) is independently 10 to 15 minutes.

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