140 results about "Particle transport" patented technology

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in "real-time" which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume. An anatomical material associated with each uniform volume element is defined and stored. Thereafter, a movement of a particle along a particle track is defined through the geometric model along a primary direction of movement that begins in a starting element of the uniform volume elements and traverses to a next element of the uniform volume elements. The particle movement along the particle track is effectuated in integer based increments along the primary direction of movement until a position of intersection occurs that represents a condition where the anatomical material of the next element is substantially different from the anatomical material of the starting element. This position of intersection is then useful for indicating whether a neutron has been captured, scattered or exited from the geometric model. From this intersection, a distribution of radiation doses can be computed for use in the cancer therapy. The foregoing represents an advance in computational times by multiple factors of time magnitudes.

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Particles, compositions, and methods that aid particle transport in mucus are provided. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles including pharmaceutical agents that have a low water / aqueous solubility. In some embodiments, a surface coating includes a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer, such as poly(vinyl alcohol) (PVA). Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

The invention relates to a method for determining the detection efficiency of an internal exposure HPGe detector based on CT data. Based on different energy gamma ray full-energy peak detection efficiency measuring data, Monte Carlo particle transport numerical values are adopted for computing, so that geometrical parameters of a detector sensitive area are adjusted, and the geometrical parameters of the detector sensitive area are obtained; the Monte Carlo particle transport numerical values are adopted for computing, so that the corresponding differential detection efficiency distribution of different energy gamma rays on the surfaces of the detector in different discrete areas and different discrete angle phase spaces is solved; based on CT medical image data of a human body to be detected, a voxel model of human anatomy structural features and a voxel model of an interesting organ or area are established, and the interesting organ or area serves as a source area; an exponential decay formula is used for solving the direct-through gamma ray share from a source area voxel to a surface element on the surface of the detector, and established differential detection efficiency distribution data are used for obtaining the detector full-energy peak detection efficiency specific to the source area through the multiple integral.

The invention discloses a method for establishing a measurement data-based simple and convenient irradiation source model of a medical linear accelerator. The method is characterized by comprising the following steps of: supposing that an irradiation source of the medical linear accelerator is on the part of the bottommost end of an MLC (Multi-leaf Collimator); measuring a flux pattern of data inversion from the accelerator through adjustment; and realizing simulation of the irradiation source of the medical linear accelerator by using a method of combining weight of outgoing particles and flux strength by combining the position of the outgaining particles with the flux distribution. Dose distribution in a template is obtained by using geometric description of a particle transport model of classic monte carlo program EGSnrc and a model of DOSXYZnrc. The method is established based on measurement data of the medical linear accelerator, so that the dependence of the conventional full accelerator simulation on the technical detail of the structure of the accelerator and heavy calculation task brought by need of sectional re-simulation in each modification process of the simulation parameter are avoided. The model can be used as an irradiation source model for an accurate monte carlo dosage calculation tool in a human body and can also be used for providing a source model for a dosage verification tool in a treatment planning system and an analytical dosage calculation tool of a treatment scheme optimization algorithm.

A system to provide enhanced computational efficiency in a simulation of particle transport through a medium, program product, and related methods are provided. The system can include a simulation data administrator server having access to an interaction database including records related to parameters describing interactions of particles in an absorbing medium to provide particle interaction parameters, and a simulated dose calculation computer in communication with the simulation data administrator server through a communications network. The system can also included simulated dose calculation program product stored in memory of the simulated dose calculation computer and including instructions that when executed by a processor causes the processor to perform for each of a plurality of particles deliverable from a particle source the operations of providing parameters for a medium to perform a Monte Carlo simulation to develop a map of simulated absorbed dose in the medium, and artificially adjusting simulation particle fluxes to achieve a substantially constant variance throughout a depth of the medium.

The invention discloses a ship reactor shielding design optimization method based on a neural network and a genetic algorithm. A Monte Carlo method is used for simulating and calculating the reactor neutron and photon transport process; an MCNP (Monte Carlo N Particle Transport Code) program is used for carrying out simulation and calculation on a ship reactor layered shielding model; a neutron and photon flux after the reactor shielding is obtained; the total equivalent dose is worked out; a topological structure of a BP (Back Propagation) neural network is determined according to the input parameter number n1 and the output parameter number n2 of a sample; an adaptation degree function of the genetic algorithm is determined according to a reactor shielding problem objective; the recommended adaptation degree function is selected; and the strong optimization capacity of the genetic algorithm is used and is mutually coupled with the neural network to find the optimum shielding parameter. The ship reactor shielding design optimization method has the advantages that the high fitting capability of the neural network is used; the time consumption of the MCNP program in the particle transport process is reduced; the good optimization capacity of the genetic algorithm is used; and the optimum shielding parameter can be found in few iteration steps.

The invention discloses a method of quick geometric processing for Monte-Carlo particle transport on basis of spatial grid partitioning and provides a cost function based spatial grid partitioning method on basis of the concept of spatial grid partitioning according to features of geometric processing of Monte-Carlo particle transport. According to the principle of minimum cost, a three-dimensional geometric model is subjected to spatial grid partitioning sequentially according to coordinate axes, geometries included in grids are determined when the cost is minimum, and a spatial grid model finally obtained is an optimal model. When the optimal model is applied to geometric processing of Monte-Carlo particle transport, spatial grid positioning can be performed fast according to particle spatial coordinates, the geometries included in the grids are traversed then, the number of candidate geometries to be searched for is greatly reduced, the geometries where particles locate can be determined fast, analog computation of Monte-Carlo particle transport is accelerated, and efficiency in geometric processing of Monte-Carlo particle transport is improved.

The invention provides a reverse Monte Carlo particle transporting and simulating system. According to a designed object or an external measuring result, and via direct reverse Monte Carlo simulating and particle transporting principle, three-dimensional transporting process and radioactive source information of radioactive intermediate particles are obtained. The reverse Monte Carlo particle transporting and simulating system comprises a state parameter and sequence inputting and processing module, an automatic modeling module, a reverse moving process simulating module, a result recording and error computing module, and a database managing module. Conventional Monte Carlo particle transporting and simulating are performed via a forward simulating method and belong to direct result simulating process according to direct reasons. In actual situation, in order to reproduce inputting or intermediate processes of the particle transportation, above information can be obtained via the reverse Monte Carlo particle transporting and simulating system. The reverse Monte Carlo particle transporting and simulating system has the advantage that intermediate and staring processes of three-dimensional particle transport is reversely simulated according to the target result, and precise simulating data for part designing, computing and optimizing of radiation dosage of a human body, breeding irradiating and the like about a nuclear device are provided.

The invention discloses a GPU-base (Graphics Processing Unit-based) multi-particle transport simulation method, which comprises the following steps that initiation is carried out; the thread number of a GPU is allocated according to the number of particles; the next collision points of the particles are computed in parallel by the GPU, whether the weight splitting or death of the particles takes place is judged, and events which are about to take place at the collision points are given; a computation result is returned to a CPU (central processing unit), and the CPU reallocates the thread number of the GPU according to the number and types of the events; the events are processed in parallel in the GPU, and the new energy, azimuths and other information of the particles and the information of produced secondary particles after the occurrence of the events are given and returned to the CPU; the CPU gathers the information and returns to the start of a program, and the steps are cycled until a simulation result of particle transport is statistically outputted. According to the embodiment of the invention, the GPU-base multi-particle transport simulation method can realize high-efficient experimental particle transport simulation, and while energy consumption is reduced, the efficiency of computation is increased.

The invention provides a medium deep charging potential and internal charging electric field acquisition method and a storage medium. The medium deep charging potential and internal charging electricfield acquisition method includes the steps: converting the orbit parameters into real-time coordinates in a geographic coordinate system by utilizing an MATLAB program according to the orbit parameters of each transfer section of the transfer orbit spacecraft, converting the real-time coordinates into real-time geomagnetic coordinates by utilizing a geomagnetic field mode IGRF, and substituting the real-time geomagnetic coordinates into a radiation band electronic environment model to obtain a real-time electronic environment energy spectrum; and taking the particle energy spectrum as an input condition, calculating the real-time particle deposition dose rate and the injection current density in the medium in particle transport simulation software Geant4, establishing a differential equation set to calculate the real-time electric field intensity and the charging potential in the medium, and identifying the deep discharge risk of the medium during satellite orbit transfer. According to the medium deep charging potential and internal charging electric field acquisition method, the medium deep charging potential and the internal charging electric field in the dynamic operation process of the transfer orbit spacecraft can be calculated, and the deep charging and discharging risk of the spacecraft when the spacecraft passes through the radiation band orbit and performs orbit transfer can be effectively evaluated.

A sliding contact arrangement comprises at least one slideway and, running thereon, at least one brush. Furthermore, a collecting vessel is provided through which the air flow caused by the movement of the slideway with respect to the brush flows. At the end of the cover, a collecting vessel for accommodating the particles transported by the air flow is provided. The collecting vessel can have a filter or else additional means for producing turbulence with the result that the air flow discharges the particles in the filter.

The invention discloses a device and a method for approximate simulation of particle transport and permeable pavement blockage under the runoff action. The device comprises a water channel, a support capable of adjusting slope of a permeable pavement model is arranged at the bottom of the water tank, the permeable pavement model is arranged in the water channel, devices used for reducing water flow state change to cause eddies and bubbles are arranged at the head and the tail of the permeable pavement level, and each device is composed of a straw array. A water tank I of a constant water head and a water tank II are arranged at the head and the tail of the water channel respectively, a particle collection device is arranged in the water tank II and disposed on an electronic balance, and a particle adding device is arranged in the upper stream of the permeable pavement. Influences on particle transport and hole blockage due to parameters such as inflow amount, infiltration flow, slope and sediment grain size are analyzed through an experiment and numerical simulation method. Research results provide a solid foundation for optimal permeable pavement design.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

The invention discloses a variable stiffness soft robot system comprising a soft robot, a vacuum pumping device and a particle conveying device; the soft robot has a cavity surrounded by an elastic deformation cavity wall, and the elastic deformation cavity wall is provided with a vacuuming passage and a conveying passage; the vacuum pumping device is connected to the vacuuming passage for extracting the air inside the cavity to realize the vacuum or negative pressure inside the cavity; the particle transport device is connected to the transport channel to transport deforming medium of the soft robot into the cavity. The soft robot system of the invention retains the characteristics that the soft robot is easy to realize complex motion and has strong environmental adaptability. At the sametime, it can also enhance the rigidity of the robot in the static state, greatly enhance the carrying capacity of the robot, enhance the practicability of the soft robot, and expand the application range of the soft robot.

A process for increasing hydrogen recovery can include:(a) sending a first gas from a hydrocarbon conversion zone at a first pressure to a hydrogen purification zone;(b) combining a second gas from a particle transport vessel at a second pressure less than the first pressure with a tail gas from the hydrogen purification zone to create a combined stream; and(c) recycling at least a portion of the combined stream to an inlet of the hydrogen purification zone.

The invention discloses a method for obtaining a proton single-particle effect cross section of a device. The method comprises a step of carrying out heavy ion single-particle effect experiment on thedevice to obtain heavy ion single-particle effect cross-section experimental data, a step of fitting the experimental data by using a Weibull function and obtaining a fitted heavy ion single-particleeffect cross-section function, a step of constructing a device structure including a plurality of metal wiring layers, calculating the nuclear reaction of protons with energy E and a material by using Monte Carlo particle transport simulation, generating secondary particle probability p(EP,L) with LET as L at a device silicon region, and further calculating an integral probability function P(EP,L), and a step of integrating a product of the heavy ion single-particle effect cross-section function and a proton integral probability function and calculating the proton single-particle effect crosssection of the device. According to the method, the evaluation of the ability of the device to resist the proton single particle can be achieved, and the method has the characteristics of clear physical concept and high accuracy of a data result.

The invention relates to a method, device and system for simulating particle transport and calculating body dosage in radiotherapy. The method for simulating particle transport includes the steps of recording the transport track of produced input particles; calculating the uncertainty of each lattice cell on the basis of the track of each batch of running particles, and determining that each lattice cell is a lattice cell reaching a standard when the uncertainty of the lattice cell does not exceed a first threshold value; obtaining the standard reaching rate of an area-of-interest, wherein the area-of-interest at least includes one lattice cell, and the standard reaching rate of the area-of-interest is the ratio of the standard reaching lattice cells in the area to all the lattice cells in the area; stopping continuing to input particles and outputting the transport track of the historical input particles if the standard reaching rate of the area-of-interest exceeds a second threshold value. The simulating efficiency of the particle transport process involved in the radiotherapy process can be improved.

The invention discloses a transition region based Monte Carlo and certainty theory coupled particle transport method. According to the particle transport method, analysis on geometry complexity is carried out based on a CAD model, the geometrically complex region is defined as an MC particle transport calculation region while the geometrically simple region is defined as a certainty-theory transport calculation region according to physical property; a transition region is created between the two regions on the basis of the physical property and thickness of the transition region is set. In particle transport calculation, MC particle transport calculation is carried out in the MC particle transport region and the transition region, certainty-theory calculation is carried out in the certainty-theory region and the transition region, and calculation results of the transition region by the two calculations are identical through multiple iterative computations, so that seamless coupling of the two calculations is realized. With the transition region, accuracy of the final calculation result is guaranteed through the multiple iterative computations. The transition region based Monte Carlo and certainty theory coupled particle transport method is an effective particle transport calculation method for shield analysis of large-size reactors.

The invention relates to a continuous-energy-point Monte Carlo particle transport method based on multi-group virtual sections. According to the method, a multi-group unionized energy grid is constructed, and section data of materials and nuclides corresponding to the multi-group unionized energy grid are calculated in advance, so that people can acquire various section data needed for transport calculation by only searching the multi-group unionized energy grid one time in each transport, and calculation time is shortened greatly. The normal nuclide continuous-energy grid is of thousands or even more energy points, and the quantity of grid points in the common unionized energy grid method is up to hundreds of thousands and even millions, but the multi-group unionized energy grid is of a small quantity of grid points, and accordingly, internal storage is reduced while single search time is shortened, calculation time is saved, and loss of calculation precision is avoided.

The invention provides a simulation method and system for particle transport. The simulation method for particle transport comprises the following steps that a simulation object, an interest area, a beam restriction device and a source are arranged; source particles are generated by sampling, and information of the generated source particles comprises the weight, direction, position and type of the source particles and comprises one of the energy and the speed of the source particles; information of the source particles and secondary particles penetrating through the beam restriction device is acquired; the secondary particles are generated by performing sampling in the interest area, and the transport process of the source particles and the secondary particles is simulated; a transport result is output, wherein a super uniform random number sampling method is adopted as the method for generating the source particles by sampling and generating the secondary particles by sampling in the interest area, and the super uniform random number is a sequence obtained through the steps that an interval is equally divided to obtain multiple numbers and the order of the numbers is disrupted.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

The invention provides a space neutral atom imaging instrument calibration method. The method includes the following steps that: step 101, a particle transport calculation tool is adopted to calculate energy deposition values of different energy particles in a sensor, and corresponding relationships between particle energy and energy deposition are recorded; step 102, the corresponding relationships between the particle energy and the energy deposition are set according to the energy channel of an neutral atom imaging instrument, the energy deposition of the particles of neutral atoms of different energy in the sensor of the neutral atom imaging instrument is calculated, and the electron energy of the electrons of the neutral atoms is calculated according to the energy deposition which is obtained through calculation, and a plurality of energy-level energy points can be obtained; and step 103, an electronic detector and an instrument to be tested which are carried by a vacuum turntable in a vacuum tank measure electron beams sequentially, and therefore, comparison testing of various indicators of the instrument to be tested can be realized. With the space neutral atom imaging instrument calibration method and device provided by the invention adopted, calibration can be provided for instruments such as neutral atom detection instruments in energy, flux accuracy and resolution, and therefore, the quality of the research and development of the instruments can be ensured.