38 results about "Liver perfusion" patented technology

The invention discloses a liver perfusion device, which comprises a main machine, an air-oxygen mixer assembly and a monitoring assembly. A consumable assembly is clamped on a worktable of the main machine, and when different livers need to be perfused, only the consumable assembly needs to be replaced, so that convenience is achieved; the main machine is internally provided with a temperature adjusting assembly in pipeline connection with the consumable assembly, thus the temperature of circulating water entering a first lung membrane oxygenator and a second lung membrane oxygenator for heatexchange can be adjusted through the temperature adjusting assembly, and then liver perfusion can be conducted under different temperature conditions according to the actual needs; and in addition, the main machine has different liver perfusion modes, a user can set hepatic artery and portal vein perfusion methods according to the actual needs, the perfusate oxygenation degree is adjusted according to an air-oxygen mixer, different drugs are injected by a micro-injection pump, and the effects of liver long-term preservation, improvement, repair and the like are achieved.

The invention relates to the medicine field, especially relates to a perfusion device, which can rapidly carry out connection and perfusion when obtaining a supplied liver in an organism (liver) transplant operation, and specifically relates to a supplied-liver quickly-fixed perfusion device for liver transplant. The perfusion device comprises a puncture guiding device and a connecting ring for connecting a perfusion pipe. The puncture guiding device is a puncture steel wire, a contractible and magnetic ring is arranged on the top end of the steel wire, the top end of the connecting ring is in a conical shape, the bottom of the connecting ring is connected to a perfusion pipe, a unidirectional valve is arranged in the bottom of the connecting ring, the top of the connecting ring is made of an iron-containing material, the top of the connecting ring is matched with the contractible ring, and the top of the connecting ring and the contractible ring absorb on each other through magnetic force. The operation of the device is simple, practicable, and pertinent. The device is mainly used to carry out rapid perfusion when obtaining a supplied liver in a liver transplant operation, and is capable of rapidly and effectively performing liver perfusion so as to obtain a high quality liver.

The invention provides a CT liver-perfusion image post-processing method and a CT liver-perfusion method. The CT liver-perfusion image post-processing method includes: obtaining a CT liver-perfusion image sequence and identifying an abdominal aorta from the CT liver-perfusion image sequence so as to obtain a time curve of a hepatic-artery contrast-agent concentration; and based on the time curve of the hepatic-artery contrast-agent concentration, calculating a contrast-agent concentration time curve of each pixel point and obtaining liver-perfusion parameters. The invention also provides a CT liver-perfusion method which uses the CT liver-perfusion image post-processing method. The CT liver-perfusion image post-processing method and the CT liver-perfusion method are higher in accuracy.

The invention discloses an in-vitro liver perfusion device which comprises a support, a clamping mechanism, a hepatic portal vein perfusion channel and a hepatic artery perfusion channel, wherein the clamping mechanism is arranged on the support and is used for clamping a ligament of the in-vitro liver so as to hang the in-vitro liver; the hepatic portal vein perfusion channel is slidably arranged on the support, and one end of the hepatic portal vein perfusion channel is communicated with a hepatic portal vein of the in-vitro liver; the hepatic artery perfusion channel is slidably arranged on the hepatic portal vein perfusion channel, and one end of the hepatic artery perfusion channel is communicated with the hepatic artery of the in-vitro liver. The ligament of the in-vitro liver is clamped through the clamping mechanism arranged on the support, so that the in-vitro liver is hung, the in-vitro liver is in a free sagging state, the whole in-vitro liver is not extruded, and the situation that the liver function is damaged due to stacking of the in-vitro liver when the in-vitro liver is directly contained in a container is prevented; and the hepatic portal vein perfusion channel and the hepatic artery perfusion channel are arranged, so that a perfusion tube can be conveniently inserted and is not easy to fall off, and perfusate can be prevented from leaking at the insertion part.

The invention discloses a simple in-vitro liver perfusion device for digesting and separating liver cells. The simple in-vitro liver perfusion device comprises a liver tissue separation sterile box and a fixing mechanism, wherein the fixing mechanism is arranged in the liver tissue separation sterile box, the fixing mechanism comprises a left extrusion unit and a right extrusion unit with the samestructure, the liver tissue is placed between the two extrusion units, a puncture needle and a sleeve are inserted into the liver tissue, perfusate flows into the liver tissue from the puncture needle, the liver tissue is clamped through opposite movement of two extrusion units, meanwhile, multiple sets of expansion units are arranged on the sleeve outside the puncture needle, the expansion unitsare formed by movably connecting multiple pairs of supporting bodies with sliding rings capable of sliding through hinge points, when the two extrusion units get close to each other, the expansion units can automatically expand outwards under the action of thrust so as to clamp and fix the liver tissue till the liver tissue is completely separated, the separation time is shortened, and thereforethe liver tissue perfusion operation efficiency is further improved.

The invention discloses a liver perfusion consumable assembly. A sealed bionic storage device is arranged in a box body of the liver perfusion consumable assembly, so that the liver perfusion consumable assembly can meet the sterility requirement in the liver perfusion process; the bionic storage device is provided with an ice adding chamber, so that ice can be continuously added by the liver perfusion consumable assembly in the liver perfusion process; and besides, a liver suspending component is arranged in a storage chamber of the bionic storage device, so that a physiological environment for livers in the liver perfusion process is relatively close to that in a living human body.

This application provides a whole-liver type bioartificial liver system dedicated pipeline, including a plasma separation pipeline, a blood storage tank, a blood storage tank drainage line, a pre-hepatic pipeline, a post-hepatic pipeline and a whole liver perfusion device; The pipeline includes a plasma separation catheter and a plasma separation pump, and the plasma separation catheter is connected with the blood storage tank to input recipient plasma; the blood storage tank drainage line includes a blood drainage catheter and a blood drainage pump, and the prehepatic pipeline includes a prehepatic catheter, liver The posterior pipeline includes the retrohepatic catheter, the blood drainage catheter, the prehepatic catheter and the retrohepatic catheter are connected sequentially in the direction from the output end of the blood storage tank to the input end, and the whole liver perfusion device is set between the anterior hepatic catheter and the retrohepatic catheter; The blood storage tank lead tube, pre-hepatic line, post-hepatic line and whole liver perfusion device constitute an extracorporeal liver perfusion cycle, and the plasma separation line and extracorporeal liver perfusion cycle are connected in parallel through the blood storage tank. The special pipeline provided by the present invention is adapted to the whole-liver bioartificial liver system, can realize the docking of various equipment in the system, and is easy to install.

The invention discloses an in-vitro liver perfusion device which comprises a perfusion liquid storage container set composed of 3 perfusion liquid storage containers, a four-way pipe, a perfusion pump, a heat exchange system, an oxygenator, a defoaming device, a perfusion catheter, a three-way pipe and a reflux pump. The in-vitro liver perfusion device can perform three-step perfusion on the in-vitro liver, maximally perform effective perfusion on the pre-perfusion liquid and digestive juice quickly and continuously, and maximally control the hepatic tissue digestion process, thereby saving the cost, keeping the temperature constant, reducing the pollution, and further obtaining sufficient experimental and clinical liver cells with high quality (especially abundant liver cells required by liver cell transplantation, biological artificial livers and the like).

The invention discloses a liver perfusion device, which comprises a main machine, an air-oxygen mixer assembly and a monitoring assembly. A consumable assembly is clamped on a worktable of the main machine, and when different livers need to be perfused, only the consumable assembly needs to be replaced, so that convenience is achieved; the main machine is internally provided with a temperature adjusting assembly in pipeline connection with the consumable assembly, thus the temperature of circulating water entering a first lung membrane oxygenator and a second lung membrane oxygenator for heatexchange can be adjusted through the temperature adjusting assembly, and then liver perfusion can be conducted under different temperature conditions according to the actual needs; and in addition, the main machine has different liver perfusion modes, a user can set hepatic artery and portal vein perfusion methods according to the actual needs, the perfusate oxygenation degree is adjusted according to an air-oxygen mixer, different drugs are injected by a micro-injection pump, and the effects of liver long-term preservation, improvement, repair and the like are achieved.

The invention discloses a gas delivery system for liver perfusion, the control module of which controls the work of the oxygen delivery control component and the compressed air delivery control component respectively according to the output results of the hepatic artery neural network training model and the portal vein neural network training model, so that the Based on the neural network training model and the preset oxygen partial pressure, carbon dioxide partial pressure and blood oxygen saturation, the real-time detection results of the hepatic artery detection module and portal vein detection module are trained respectively, and the gas in the hepatic artery and portal vein can be adjusted in real time and accurately delivery volume, so that the oxygen partial pressure, carbon dioxide partial pressure and blood oxygen saturation can be output stably according to the predetermined value; moreover, the bottom of the base is also equipped with universal wheels, so that the gas delivery system can be used and installed in different surgical sites ; In addition, when the gas storage capacity in the oxygen storage cylinder and the compressed air storage cylinder reaches a critical value, the relevant information can be notified to the operator in time through the alarm module.

The present invention discloses a temperature control system for liver perfusion. The system comprises a control module, a power module for supplying power to the temperature control system, a water tank for accommodating circulating water, a temperature regulator, a temperature monitoring component for monitoring the temperature of circulating water, and a centrifugal pump for driving circulatingwater into a pulmonary membrane oxygenator for heat exchange and returning the water to the water tank. The control module controls the temperature regulator to adjust the temperature of the circulating water according to the monitoring result of the temperature monitoring component, so that the temperature of the circulating water can be adjusted by using the temperature monitoring component andthe temperature regulator, and the temperature of the perfusate can be adjusted according to the temperature requirement of the liver perfusion.

The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to the design of a chamber in which a biological component can be housed to form e.g. a bio-artificial liver (BAL). It also relates to a bio-artificial liver per se, it's components and methodological steps associated with its development and use. The chamber (10) for the biological component (100) of a bio-artificial liver (200) is configured to allow: •Proliferation of the biological component, in situ; •Cryopreservation of the biological component, in situ, and •Perfusion of the biological component, in situ.