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Perfusion regulation

A technology for organ perfusion and blood vessels, which can be used in hypodermic injection devices, treatment, and other medical devices, and can solve problems such as organ failure and insufficient perfusion fluid

Active Publication Date: 2014-07-09
LIFELINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low pressure perfusion may provide insufficient perfusate to organs leading to organ failure

Method used

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Embodiment Construction

[0033] For a general understanding of the features of the invention, reference is made to the accompanying drawings. In the drawings, the same reference numerals have been used throughout to designate the same elements.

[0034] The disclosed systems and methods include transport, storage, perfusion, and diagnosis of organs. However, the disclosed systems and methods may have other applications and thus should not be considered limited to a particular context of use. The various disclosed features may be particularly adapted in the context of, and may be combined with and / or associated with, the features of the devices and methods disclosed in: U.S. Patent Application No. 09 / 162,128 (now abandoned) , US Patent Nos. 6,977,140 and 6,673,594, and US Patent Application Publication Nos. 2004-0248281, 2004-0221719 and 2004-0111104, the entire contents of which are incorporated herein by reference.

[0035] figure 1 An organ perfusion device 1 is shown. figure 2 yes figure 1 Sc...

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Abstract

A system and method for cooperatively regulating the pressure and flow of an afferent vessel, such as both the hepatic portal vein and the hepatic artery. The present invention solves the problem of less-than-therapeutic portal flow during perfusion preservation by implementing cooperative regulation of inputs, such as the portal vein and hepatic artery pumping systems, on the organ preservation device. The system includes an algorithm adapted to the situation where the portal vein has reached minimum flow and maximum pressure. A cooperative regulation algorithm detects a problem with the portal vein and resolves it by adjusting the flow state of the hepatic artery.

Description

technical field [0001] The present invention relates to methods and systems for perfusing one or more organs, tissues, etc. (hereinafter "organs") in a prescribed and controlled manner to maintain, preserve or enhance organ viability. Background technique [0002] Perfusion devices for implantable organs are described in the scientific and patent literature. Such a device is described, for example, in US Patent No. 6,977,140, ​​assigned to Organ Recovery Systems, Inc., the entire contents of which are incorporated herein by reference. However, US Patent No. 6,977,140 is silent on certain aspects of perfusing a multi-inflow organ such as the human liver. [0003] Ideally, harvesting of organs should be done in a manner that limits their thermal ischemia time. Unfortunately, many organs, especially from post-cardiac donors, are harvested after prolonged warm ischemia times, such as 45 minutes or more. Machine perfusion of these organs is optimal at low temperatures (Transpl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/00A01N1/02
CPCA01N1/02A61M1/1086A61M2205/3331A01N1/0247A61N1/00A61N1/02A01N1/021
Inventor J·布拉斯尔
Owner LIFELINE SCI
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