The invention belongs to the technical field of
biomedical engineering and
microfluidics, and particularly relates to an
organoid-vascular
system integrated development
chip and a synchronous culture method thereof. The
chip comprises an
artery fluid channel, a
vein fluid channel and at least one
organoid culture unit connected between the
artery fluid channel and the
vein fluid channel, the
organoid culture unit comprises a target organoid culture cavity and an
artery /
vein vessel organoid culture cavity which is communicated between the artery / vein channel and the target organoid culture cavity. According to the invention, a vascular organ is used as a
vascular network hair growing center, is communicated with arteries / veins outwards under the guidance of a specific structure of the
chip, and is integrated with a
target organ inwards to form an artery-vascularized organ-vein structure. The method not only solves the problems of insufficient integration and asynchronous development of the organoid and the vascular
system, but also has the research potential of high-
throughput culture and multi-organ interaction, and provides a high-bionic in-vitro model for
drug research and development and
disease modeling.