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Compoiste preparation of cefuoxime sodium

A technology of cefuroxime sodium and cefuroxime, which is applied in the field of antibacterial compound pharmaceutical preparations to achieve the effects of reduced drug consumption, convenient production, and reduced side effects

Inactive Publication Date: 2005-02-23
SHENYANG J & HEALTH PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The combination of cefuroxime or its physiologically acceptable salts and β-lactamase inhibitors has not been reported in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The in vitro antibacterial activities of cefuroxime alone and cefuroxime / tazobactam compound were compared by agar double dilution method. The comparison results are shown in Table 1

[0026] Strain (strain)

Embodiment 2

[0028] Accurately weigh 1.00 g of cefuroxime sodium sterile powder and 0.25 g of tazobactam sodium sterile powder, mix them in a sterile environment, and fill them to make sterile powder for injection.

Embodiment 3

[0030] Accurately weigh 2.00 g of cefuroxime sodium sterile powder and 0.50 g of tazobactam sodium sterile powder, mix them in a sterile environment, and fill them to make sterile powder for injection.

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PUM

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Abstract

A composite cefuroxime sodium is prepared from cefuroxime sodium or its salt and beta-lactamase inhibitor in weight ratio of (4-8):1.

Description

Technical field: [0001] The invention relates to a compound drug preparation, in particular to an antibacterial compound drug preparation containing cefuroxime or a physiologically acceptable salt thereof and a β-lactamase inhibitor. Background technique: [0002] With the widespread use of β-lactam antibiotics, the resistance rate of various bacteria to antibiotics is increasing day by day. One of the reasons is that the bacteria produce a new β-lactamase, namely inducible β-lactamase (Induced enzyme) and extended-spectrum β-lactamase (extended-spectrum enzyme), and become the main mechanism of bacterial drug resistance in today's clinical anti-infection treatment, bringing new difficulties to the treatment of antibiotics. Extended-spectrum β-lactamases are mainly produced by Enterobacteriaceae, especially Klebsiella pneumoniae and Escherichia coli. Extended-spectrum β-lactamase-producing bacteria are highly resistant to all first- and second-generation cephalosporins. Ce...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61P31/04
Inventor 纪晓琳马军芳
Owner SHENYANG J & HEALTH PHARMA