The invention discloses health-care instant powder for people suffering from hyperlipidemia, hypertension and hyperglycemia. The health-care instant powder is prepared from raw materials as follows: dendrobium officinale, soybean meal, tea powder, kelp powder, tapioca flour, rice bran, fish oil, mushroom powder, laver powder, spina date seeds, bitter gourd powder, peach kernel powder, oat meal, cyclocarya paliurus leaves, ginseng, tuber fleeceflower roots, safflower, Chinese angelica, szechuan lovage rhizomes, fructus lycii, twotooth achyranthes roots, roots of redsepal eveningprimrose, pseudo ginseng, hawthorn fruits, lotus leaves, ginkgo leaves, pinellia tuber, cassia seeds, liquorice, pinus densiflora leaves, hemp fruits, persimmon leaves, parslane herbs, beewax, bottle brush herbs, wintercherries, dahurian rose fruits, motherwort herbs, earthworms, eucommiae folium, kudzuvine roots, cellulase, pectinase, black fungus polysaccharide extracts, a vitamin mixture, dextrin, 6-hydroxyflavanone, steviosin, adenosine monophosphate and mannitol. The invention further provides a preparation method of the health-care instant powder for people suffering from hyperlipidemia, hypertension and hyperglycemia. The health-care instant powder containing dendrobium officinale tastes mellow and sweet and can effectively reduce lipid, blood pressure and blood glucose of people suffering from hyperlipidemia, hypertension and hyperglycemia.