The invention discloses a method for making a tangerine peel and winter melon paste moon cake, which comprises the following steps: (1) making winter melon paste stuffing: a) cleaning winter melon, peeling off, removing pulp, cutting into small strips of 5-8cm, stir-frying, removing most of water, adding sugar and edible oil and stir-frying together; b) placing tangerine peel in clear water for soaking, removing an inner membrane and chopping; and c) simultaneously adding one or more of ginseng, cordyceps flower and remote lemongrass herb into winter melon paste obtained in the step a), stir-frying and preparing tangerine peel and winter melon paste stuffing; (2) making a crust: taking an appropriate amount of flour, mixing the sugar and the edible oil, adding an appropriate amount of alkaline water, kneading into a dough, and further preparing the crust; and (3) using the crust as an outer skin, wrapping the tangerine peel and winter melon paste stuffing, placing into a die for forming, further placing into an oven for baking, cooling, packaging and preparing the tangerine peel and winter melon paste moon cake. The tangerine peel and winter melon paste moon cake made by the method has low fat and high fiber, is nutritional, delicious and wholesome, and can promote the development of agricultural economy to a certain extent.