The present invention discloses compound blueberry buccal tablets and a preparation method thereof. The compound blueberry buccal tablets are mainly composed of the following raw materials in the following parts by weight: 40-60 parts of blueberry anthocyanin extract powder, 6-10 parts of calcium powder, 15-25 parts of seaweed powder, 5-15 parts of peppermint oil, 1-5 parts of semen sterculiae lychnophorae powder, 1-5 parts of chrysanthemum powder, 1-5 parts of litchi juice, 50-70 parts of soybean protein solution, and a proper amount of water. The blueberry buccal tablets are sour, sweet andrefreshing in taste, contain a variety of health-care active ingredients, and have more obvious functions of protecting vision, refreshing mind and improving eyesight. At the same time, the various raw materials are balanced in nutrition and reasonable in matching, and rich in anthocyanins, flavonoids, vitamins, trace elements and other health-care substances. The blueberry buccal tablets producea large amount of carbon dioxide gas after entering water, and thus are quickly dissolved, rapid in drug effects, high in bioavailability, easy to carry, and low in cost.