The invention relates to the technical field of
traditional Chinese medicine extraction, and discloses a preparation method of a fructus
cannabis extract. The preparation method comprises the following steps: preparing fructus
cannabis decoction pieces into coarsest
powder, putting the coarsest
powder and water with the weight being 6-12 times that of the coarsest
powder into an extraction tank, adding beta
cyclodextrin with the weight being 2-10% of that of the coarsest powder of fructus
cannabis into water with the weight being 5-20 times that of the coarsest powder of fructus cannabis to prepare a beta
cyclodextrin solution, dynamically stirring, keeping micro-boiling decoction for 0.5-3h, and filtering to obtain a first extracting solution and
medicine residues; putting the
medicine residues and water with the weight being 5-12 times that of the coarsest powder of fructus cannabis into the extraction tank, dynamically stirring, keeping micro-boiling decoction for 0.5-3h, and filtering to obtain a second extracting solution; combining the two extracting solutions, and centrifuging to obtain a centrifugate; and carrying out low-temperature reduced pressure concentration on the centrifugate until the
relative density is 1.05-1.15, measuring the
relative density at 60 DEG C, and carrying out
spray drying or belt
drying to obtain the fructus cannabis extract. According to the preparation method, water-soluble substances of fructus cannabis can be effectively extracted, and fat-soluble components can be effectively extracted, so that a complex process of oil pressing and theninclusion is avoided, and the process is effective, simple and feasible and is suitable for large-scale production.