The invention relates to the technical field of
traditional Chinese medicine preparations, and discloses a plaster for treating pain in neck, shoulders,
waist and legs, which comprises a volatile and heat-sensitive medicinal material group, a heat-resistant medicinal material group with toxic components, a floating medicinal material group,
sesame oil, a composite micro-
coating matrix and a physical activator. During preparation, volatile and heat-sensitive medicinal materials are pretreated by adopting a composite micro-
coating matrix, and toxic medicinal materials are subjected to micro-
wetting treatment by adopting a physical exciting agent; and putting the mixed
powder to be fed into high-temperature
sesame oil at one time for reaction, then transferring to a closed mechanical forming cavity, and forming through a warm-pressure
coupling process of medium-
temperature normal pressure, high-temperature positive-pressure intense
permeation and medium-temperature negative-pressure sudden drop. According to the invention, the degradation of toxic diester-type
alkaloid and the retention of thermosensitive components are synchronously realized by utilizing the
phase change heat insulation of the
coating substrate and the
vaporization and micro-boiling mechanism of the exciting agent, and the physical topological structure of the plaster is remolded through temperature-pressure
coupling, so that the leaching amount of effective components, the transdermal release efficiency and the product forming stability are improved.