Application of phenylpropanoids compounds in preparation of medicines for treating inflammatory diseases
A technology for inflammatory diseases and compounds, applied in the field of medicine, can solve problems such as complex biological effects, and achieve the effects of high purity, simple extraction and separation methods, and easy synthesis
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Embodiment 1
[0049] The preparation of embodiment 1 phenylpropanoid compound
[0050] This example provides a preparation method for phenylpropanoid compounds represented by formula (I), comprising the following steps:
[0051] S1. Take 50 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. Reflux extraction with 8 times the amount of 60% ethanol for 3 times, each time for 2 hours, combine the extracts, concentrate until there is no alcohol smell, and obtain the extract for later use;
[0052] S2. Dissolve the extract concentrated in step S1 in 10L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is water, and the eluent is eluted for 3 column volumes. The eluate is collected and named as MM -1, standby;
[0053] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume ratio is 25:75, and 18 column volumes are eluted, ...
Embodiment 2
[0056] The preparation of embodiment 2 phenylpropanoid compounds
[0057] This example provides a preparation method for phenylpropanoid compounds represented by formula (I), comprising the following steps:
[0058] S1. Take 40 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. After reflux extraction with 6 times the amount of 50% ethanol twice, each time for 1 hour, the extracts were combined and concentrated until there was no alcohol smell, and the extract was obtained for later use;
[0059] S2. Dissolve the concentrated extract in step S1 in 5L of water, and use D101 macroporous adsorption resin column to elute it. The eluent is ethanol and water with a volume ratio of 15:85, and eluted for 3 column volumes , collect the eluate, name it MM-1, and set aside;
[0060] S3. The fraction MM-1 collected in step S2 is eluted with reverse-phase ODS column chromatography, the eluent is methanol-water system, and its volume ratio is 2...
Embodiment 3
[0063] The preparation of embodiment 3 phenylpropanoid compounds
[0064] This example provides a preparation method for phenylpropanoid compounds represented by formula (I), comprising the following steps:
[0065] S1. Take 60 kg of big-leaved jackfruit, use the root as raw material, dry it, and cut it into small pieces. 7 times the amount of 70% ethanol was refluxed and extracted 4 times, each time for 3 hours, the extracts were combined, concentrated until there was no alcohol smell, and the extract was obtained for later use;
[0066] S2. Dissolve the concentrated extract in step S1 in 8L of water, and use a D101 macroporous adsorption resin column to elute it. The eluent is ethanol and water with a volume ratio of 10:90, and eluted for 3 column volumes , collect the eluate, name it MM-1, and set aside;
[0067] S3. The fraction MM-1 collected in step S2 is eluted with reversed-phase ODS column chromatography, the eluent is methanol-water system, its volume ratio is 30:7...
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