Technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC

The technology of protocatechuic acid and process method is applied in the field of extraction of protocatechuic acid, can solve the problems of low preparation purity, complicated preparation process, difficult industrialized production and the like, and achieves high extraction yield, high separation ability and simple method Effect

Active Publication Date: 2014-10-15
广西万寿堂药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In order to solve the above technical problems, the object of the present invention is to provide a process for extracting protocatechuic acid from Diangui Ainaxiang, which solves the problems of low preparation purity, small preparation amount, complicated preparation process and difficulty in realizing industrialized production. Through water extraction, concentration, extraction, elution and other processes, it can achieve high extraction purity and simple process preparation, which is suitable for promotion and meets people's demand for protocatechuic acid

Method used

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  • Technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC
  • Technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC
  • Technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC

Examples

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Embodiment 1

[0032] The process of extracting protocatechuic acid from Yunnan osmanthus Ainaxiang:

[0033] Put the impurity-removed medicinal material of Yunnan Gui Ainaxiang into an extraction tank, add water to decoct twice, add 10 times the amount of water for decoction for 1.5 hours for the first time, and decoct for 1 hour with 10 times the amount of water for the second time, and control the temperature at 60°C, filter with a 200 mesh filter cloth, and combine the filtrates; Concentration: The filtrate is concentrated to a concentrated solution with a relative density of 1.08 at 58°C, moved to a sedimentation tank, and left to stand for 8 hours. An extract with a relative density of 1.36 °C; the extract is dissolved in 5 times the amount of water and heated to 65°C, dissolved and filtered to obtain an aqueous solution of the extract, adjusted to a pH of 6, extracted with butanone, and the total amount of butanone is controlled at 0.2 ~1 times the volume of the aqueous extract soluti...

Embodiment 2

[0035] The process of extracting protocatechuic acid from Yunnan osmanthus Ainaxiang:

[0036] Put the impurity-removed medicinal material of Yunnan Gui Ainaxiang into the extraction tank, add water to decoct twice, add 10 times the amount of water to decoct for 1.5 hours for the first time, add 8 times the amount of water to decoct for 1 hour for the second time, and control the temperature to 65°C, filter with a 180 mesh filter cloth, and combine the filtrates; Concentration: The filtrate is concentrated to a concentrated solution with a relative density of 1.08 at 65°C, moved to a sedimentation tank, left standing for 8 hours, and treated by sedimentation and centrifugation, and the clear filtrate is concentrated to 65°C The extract with a relative density of 1.38 °C; the extract is dissolved in 5-8 times the amount of water and heated to 60°C, dissolved and filtered to obtain an aqueous solution of the extract, adjusted to a pH of 5, extracted with butanone, and the total a...

Embodiment 4

[0041] The difference between this example and the above example is that, besides methyl ethyl ketone, the organic solvent can also be one of n-butanol, ethyl acetate, diethyl ether or petroleum ether, and the total amount of organic solvent is controlled to be 0.2 to 1 times The volume of aqueous extract solution.

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Abstract

Belonging to the technical field of traditional Chinese medicine extraction, the invention discloses a technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC. The method for preparation of a protocatechuic acid monomer consists of: water extraction, concentration, extraction, elution, and TLC preparation and purification. A compound B is determined as protocatechuic acid with a concentration of equal to or more than 99% by HPLC analysis, and is the protocatechuic acid monomer. The technological method for extraction of chlorogenic acid from Blumea riparia (Bl.) DC solves the problems of low preparation purity, small preparation quantity, complex preparation process, and difficult realization of industrialization production. By means of water extraction, concentration, extraction, elution and other processes, high extraction purity and a simple preparation process can be realized. Thus, the method is suitable for popularization, and meets the need of people for protocatechuic acid.

Description

technical field [0001] The invention relates to the technical field of extracting traditional Chinese medicines, in particular to a process for extracting protocatechuic acid from laurel laurel. Background technique [0002] Diangui Ainaxiang Blumea riparia (BL.) DC, also recorded in "Flora of China", is called False Dongfengcao [1], and the whole herb is commonly used as medicine by folks. It is recorded in "Chinese Medicine Sea" that the nature and flavor of Diangui Ainaxiang belong to the meridians: light, sweet and flat, enter the three meridians of liver, kidney and bladder; efficacy and indications to promote blood circulation and stop bleeding - this product is sweet and light into the liver, nourishes the liver and activates blood circulation, astringent and hemostasis , has the function of promoting blood circulation without hurting blood, stopping bleeding without leaving silt, and can be used for various hemorrhages; diuresis and swelling—this product is sweet and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C65/03C07C51/42
CPCC07C51/42C07C65/03
Inventor 李修善韦莉萍黄小珊叶善洋
Owner 广西万寿堂药业有限公司
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