The invention discloses a compound
screening method and
system for regulating and controlling permeability of a
blood brain barrier, and relates to the technical field of
medicine screening, and the method comprises the following specific steps: S100, collecting multi-
omics data of
blood brain barrier related cells to form an original set; s200, preprocessing the data and standardizing the data; s300, constructing a
molecular network through cross-
omics analysis, and screening key targets; s400, integrating target spot information to establish a structured target
pool; s500, molecular docking and
primary cell verification are carried out, and compounds capable of effectively regulating and controlling the permeability of the
blood brain barrier are screened out. Through multi-
omics integration and cross-omics analysis, a
gene-
protein-
metabolite network is constructed, key targets of the blood brain barrier are accurately recognized, and a high-credibility target
pool is provided; molecular docking and
primary cell mixed culture verification are combined, efficient screening and
functional safety evaluation of candidate compounds are achieved, the research and development cost is remarkably reduced, and an efficient technical path is provided for
drug research and development.