The invention relates to a field device information management system based on semantics and OPC UA and belongs to the combined field of the semantic network and the industrial Internet of things. Theintegral configuration of the system comprises a sensing layer, a network layer, a semantic layer and an application layer, wherein the sensing layer comprises a bottom field device and an OPC UA server, the network layer comprises each network system accessed by the OPC UA, the semantic layer comprises an OPC UA device information acquisition end, a device information management domain knowledgeontology model, a device information semantic annotation module, a semantic reasoning and query module, an ontology database and a semantic rule file, and the application layer comprises a device running state management module, a device operator management module, a device machine account management module, a device spare part management module, a device maintenance management module and a device repair management module. The management system is advantaged in that semantic integration of the heterogeneous device information is realized, through semantic reasoning and query, the relatively rich semantic knowledge in the field can be acquired, and needs of each functional module of the system are satisfied.