Application of pawpaw total phenolic acid extract in preparation of arthritis prevention and treatment medicaments or food

A technology of total phenolic acids and extracts, which is applied in the field of medicine, can solve the problems that there are no existing papaya total phenolic acids extracts, etc., and achieve the effect of obvious activity and simple preparation method

Inactive Publication Date: 2012-08-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In research at home and abroad, there are currently reports on the anti-inflammatory and analgesic aspects of total glycosides and total phenolic acid extracts of papaya (Chinese Journal of Experimental Formulas, 2011, 17(1): 113-116, 119; Journal of Medical Food, 2009, 12(5): 1016-1022), but there is no report that papaya total phenolic acid extract is used to prevent and treat gouty arthritis or rheumatoid arthritis

Method used

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  • Application of pawpaw total phenolic acid extract in preparation of arthritis prevention and treatment medicaments or food
  • Application of pawpaw total phenolic acid extract in preparation of arthritis prevention and treatment medicaments or food
  • Application of pawpaw total phenolic acid extract in preparation of arthritis prevention and treatment medicaments or food

Examples

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Embodiment 1

[0023] Example 1 Preparation of papaya total phenolic acid extract

[0024] After crushing 100kg of dried Chinese medicine papaya, pass through a 10-mesh sieve, put it into an extraction tank, soak for 24 hours with 200L of 70% ethanol aqueous solution at room temperature, extract 3 times with 1500L of 70% ethanol aqueous solution at room temperature, and combine the soaking solution and The filtrate is concentrated to 50L, filtered, and the filtrate is adsorbed with polystyrene porous adsorption macroporous resin as usual. The macroporous resin in the column is 200L, rinsed with 1500L distilled water to remove impurities, and then washed with 10% ethanol aqueous solution Carry out elution, collect 2000L eluate, concentrate until there is no alcohol smell, then perform secondary macroporous resin adsorption and desorption in the same way, and obtain 0.25 kg of tan powdery total phenolic acid extract of papaya after drying. Calculated according to the dosage of crude drug, the ...

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Abstract

The invention relates to the technical field of medicaments and particularly relates to application of a pawpaw total phenolic acid extract in preparation of arthritis prevention and treatment medicaments or food, which is characterized in that the arthritis is gouty arthritis or rheumatoid arthritis. According to the invention, a pawpaw total phenolic acid extract is prepared from pawpaw fruit, and according to component analysis, the pawpaw extract comprises the following main components: protocatechuic acid, chlorogenic acid and other phenolic acid compounds, wherein the protocatechuic acid accounts for 30% to 35%, the chlorogenic acid accounts for 20% to 25%, and the phenolic acid compounds account for 50% to 60% of the pawpaw extract. Therefore, the product is called the pawpaw total phenolic acid extract. Animal experiments prove that the pawpaw total phenolic acid extract disclosed by the invention has obvious activity for preventing and treating the gouty arthritis or the rheumatoid arthritis, thus being used for preparing the medicament or food for preventing and treating the gouty arthritis or the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of papaya total phenolic acid extract for preparing medicine or food for preventing and treating gouty arthritis or rheumatoid arthritis. Background technique [0002] Gouty arthritis is a metabolic bone and joint disease caused by the deposition of urate in the joints due to the increase of blood urate concentration caused by purine metabolism disorder, which mainly invades the synovium, articular cartilage and subcutaneous tissue of the joint. During the onset, the small joints of the lower extremities were suddenly red, swollen, hot and painful, and could not walk, which was very painful. Modern medicine believes that the main pathological change of the acute attack of gouty arthritis is the deposition of uric acid crystals (MSU) in the tissues around the joints, causing an acute inflammatory response. MSU binds to IgG in synovial fluid and is phagocytized by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A23L1/29A61P19/02A61P19/06A61P29/00A23L33/00
Inventor 孙连娜李霞杨颖博邱彦席忠新孙蕾陈万生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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