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Application of protocatechuic acid in preparation of drugs for preventing and controlling livestock and poultry virus infectious diseases

A technology for infectious diseases and protocatechuic acid, which is applied in the application field of protocatechuic acid in the preparation of medicines for preventing and treating viral infectious diseases of livestock and poultry, can solve the problem that there is no effective solution for viral diseases, and no protocatechuic acid has been seen. acid and other problems

Active Publication Date: 2011-08-17
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In addition, the safety of livestock and poultry food has attracted the attention of consumers. Western medicines such as ribavirin, amantadine, and morpholino hydrochloride have been banned from domestic animals. There is no effective solution for the treatment of the disease, and it is urgent for researchers to screen out new antiviral drugs.
[0017] So far, there has been no report on the application of protocatechuic acid in the prevention and treatment of the above-mentioned livestock and poultry viral infectious diseases

Method used

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  • Application of protocatechuic acid in preparation of drugs for preventing and controlling livestock and poultry virus infectious diseases
  • Application of protocatechuic acid in preparation of drugs for preventing and controlling livestock and poultry virus infectious diseases
  • Application of protocatechuic acid in preparation of drugs for preventing and controlling livestock and poultry virus infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: protocatechuic acid injection

[0035] 1. Composition (the content of protocatechuic acid is 100mg / ml): 10g of protocatechuic acid, 30ml of absolute ethanol, 40ml of Tween-20, add water for injection to 100ml.

[0036] 2. Preparation method:

[0037] 1) Weigh the raw and auxiliary materials respectively according to the prescription quantity, and set aside;

[0038] 2) Dissolve protocatechuic acid in absolute ethanol, add 30ml of absolute ethanol to dissolve, add Tween-20 40ml, mix well, slowly dissolve to 100ml with water for injection, and sterilize to obtain protocatechuic acid Injection.

Embodiment 2

[0039] Embodiment 2: protocatechuic acid injection

[0040] 1. Composition (protocatechuic acid 100mg / ml): 10g protocatechuic acid, 30ml absolute ethanol, 40ml Tween-20, 5ml glycerol (or glycerin), add water for injection to 100ml.

[0041] 2. Preparation method:

[0042] 1) Weigh the raw and auxiliary materials respectively according to the prescription quantity, and set aside;

[0043] 2) Dissolve protocatechuic acid in absolute ethanol, add Tween solution and glycerin after dissolving, mix well, slowly dilute to 100ml with water for injection, and sterilize to obtain protocatechuic acid injection .

Embodiment 3

[0044] Embodiment 3: protocatechuic acid oral liquid

[0045] 1. Composition (protocatechuic acid 100mg / ml): 10g protocatechuic acid, 40ml absolute ethanol, 30ml Tween-20, add sterilized water to 100ml.

[0046] 2. Preparation method

[0047] 1) Weigh the raw and auxiliary materials respectively according to the prescription quantity, and set aside;

[0048] 2) Dissolve protocatechuic acid in absolute ethanol, add Tween-20, mix well, and slowly dilute to 100ml with sterilized water to obtain protocatechuic acid injection.

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Abstract

The invention provides an application of protocatechuic acid in the preparation of drugs for preventing and controlling livestock and poultry virus infectious diseases. The viruses include infectious bursal disease virus, avian influenza virus, infectious bronchitis virus and / or porcine transmissible gastroenteri tis virus. Meanwhile, the invention also relates to a protocatechuic acid preparation and a preparation method thereof.

Description

technical field [0001] The invention relates to a new application of protocatechuic acid, in particular to the application of protocatechuic acid in the preparation of medicines for preventing and treating viral infectious diseases of livestock and poultry. The invention also relates to a preparation of protocatechuic acid and a preparation method thereof. Background technique [0002] Protocatechuic acid (PCA), as shown in formula I, chemical name is 3,4-dihydroxybenzoic acid, CAS registration number is 99-50-3, molecular formula is (HO) 2 C 6 h 3 COOH, molecular weight: 154.12. [0003] [0004] Formula I [0005] The product is white to brown crystalline powder that changes color in air. Density 1.54g / cm 3 ; Melting point about 200 ° C (decomposition); Solubility: soluble in 50 parts of water, soluble in ethanol, ether. [0006] Protocatechuic acid is a phenolic compound that has been widely studied. It has various pharmacological activities such as anti-platelet...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/14A61K9/08A61K9/16A61K9/20A61P31/16A61P31/14
CPCY02A40/70
Inventor 何诚欧长波陈曦潘青
Owner CHINA AGRI UNIV
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