Solid preparation of 'Fuxiekang' and preparation method

A Fuxuekang and solid technology, which is applied in the fields of pill delivery, blood diseases, and pharmaceutical formulations, can solve the problems that granules are easy to absorb moisture and deteriorate, easy to absorb moisture and agglomerate, and take a large amount, so as to achieve rapid drug dissolution and collapse The effect of short solution time and small dosage

Inactive Publication Date: 2005-06-15
BEIJING BOERDA BIO TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the Fuxuekang preparations on the market are granules, which are large in dosage, easy to absorb moisture and agglomerate, and have poor stability. Therefore, we have de

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1-Fuxuekang Tablets

[0040] Diangui Ainaxiang 1000g

[0041] Pregelatinized starch 100g

[0042] Sodium Carboxymethyl Starch 6g

[0043] 2% hypromellose appropriate amount

[0044] Magnesium Stearate 2.0g

[0045] A total of 1000 pieces

[0046] Method:

[0047]Extraction process: take Diangui Ainaxiang, add water to decoct for two times, the first time is 1.5 hours, the second time is 1 hour, the decoction is combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.08 (60 ° C), Let stand for 8 hours, filter, and concentrate the filtrate to a thick paste with a relative density of 1.36-1.38 (60° C.), and freeze-dry to obtain an extract.

[0048] Forming process: 1. Take hypromellose and add water to make a 2% solution.

[0049] 2. Take Diangui Ainaxiang extract, pregelatinized starch and sodium carboxymethyl starch with half the prescription amount, pass through a 100-mesh sieve and mix evenly with 2% hypromellos...

Embodiment 2

[0052] Example 2-Fuxuekang Tablets

[0053] Diangui Ainaxiang 500g

[0054] Microcrystalline Cellulose 100g

[0055] Crospovidone 6g

[0056] 5% povidone appropriate amount

[0057] Magnesium Stearate 2.0g

[0058] 1000 pieces in total

[0059] Method:

[0060] Extraction process: take Diangui Ainaxiang, add water to decoct twice, the first time is 1.5 hours, the second time is 1 hour, the decoction is combined, filtered, and the filtrate is spray-dried in a spray drying device to obtain the extract.

[0061] Molding:

[0062] 1. Take povidone and add water to make a 5% solution.

[0063] 2. Take Diangui Ainaxiang extract and microcrystalline cellulose, pass through an 80-mesh sieve and mix evenly, and use 5% povidone to make soft material. Granulate with an 18-mesh sieve, dry at 50°C, and granulate with an 18-mesh sieve. Add magnesium stearate and crospovidone, mix well, and press into tablets.

[0064] The disintegration time limit and content of the tablets prepar...

Embodiment 3

[0066] Example 3-Fuxuekang Tablets

[0067] Diangui Ainaxiang 250g

[0068] Lactose 150g

[0069] Croscarmellose Sodium 15g

[0070] 5% povidone appropriate amount

[0071] Magnesium Stearate 2.0g

[0072] 1000 pieces in total

[0073] Method:

[0074] Extraction process: take Diangui Ainaxiang, add water to decoct twice, the first time is 1.5 hours, the second time is 1 hour, the decoction is combined, filtered, and the filtrate is boiled and dried in a boiling drying device to obtain the extract.

[0075] Forming process: 1. Take povidone and add water to make a 5% solution.

[0076] 2. Take Fuxuekang extract and lactose through a 100-mesh sieve and mix them evenly to make soft material with 5% povidone. Granulate with a 20-mesh sieve, dry at 50°C, and granulate with a 20-mesh sieve. Add magnesium stearate and croscarmellose sodium, mix well, and press into tablets.

[0077] The disintegration time limit and content of the tablets prepared above were measured accord...

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PUM

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Abstract

A Chinese medicine 'Fuxuekang' in the form of tablet or capsule is prepared from balsamiferous blumea and protocatechuic acid through extracting of balsamiferous blumea, drying, and proportionally mixing it with protocatechuic acid.

Description

technical field [0001] The invention relates to solid preparations of Fuxuekang, specifically Fuxuekang tablets, Fuxuekang capsules and Fuxuekang dispersible tablets, and at the same time, the invention also relates to preparation methods of three preparations. Background technique [0002] Fuxuekang Granules is a pure traditional Chinese medicine preparation developed by modern pharmaceutical technology on the basis of Yao folk prescriptions in the western mountainous area of ​​Guizhou. The medicine has the functions of invigorating blood and promoting blood circulation, removing blood stasis and regenerating, astringing blood and stopping bleeding, and promoting uterine involution. , the total effective rate is 97.1%. [0003] At present, the Fuxuekang preparations on the market are granules, which are large in dosage, easy to absorb moisture and agglomerate, and have poor stability. Therefore, we have developed Fuxuekang tablets, dispersible tablets and capsules, which h...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61P7/04A61P15/00
Inventor 张成飞孟旻
Owner BEIJING BOERDA BIO TECH DEV
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